Cerebral salt-wasting syndrome after hematopoietic stem cell transplantation in adolescents: 3 case reports
Annals of Pediatric Endocrinology & Metabolism
; : 220-225, 2015.
Article
em En
| WPRIM
| ID: wpr-96137
Biblioteca responsável:
WPRO
ABSTRACT
Cerebral salt-wasting syndrome (CSWS) is a rare disease characterized by a extracellular volume depletion and hyponatremia induced by marked natriuresis. It is mainly reported in patients who experience a central nervous system insult, such as cerebral hemorrhage or encephalitis. The syndrome of inappropriate antidiuretic hormone secretion is a main cause of severe hyponatremia after hematopoietic stem cell transplantation, whereas CSWS is rarely reported. We report 3 patients with childhood acute leukemia who developed CSWS with central nervous system complication after hematopoietic stem cell transplantation. The diagnosis of CSW was made on the basis of severe hyponatremia accompanied by increased urine output with clinical signs of dehydration. All patients showed elevated natriuretic peptide and normal antidiuretic hormone. Aggressive water and sodium replacement treatment was instituted in all 3 patients and 2 of them were effectively recovered, the other one was required to add fludrocortisone administration.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Poliúria
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Sódio
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Fludrocortisona
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Células-Tronco Hematopoéticas
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Água
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Leucemia
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Sistema Nervoso Central
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Hemorragia Cerebral
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Transplante de Células-Tronco Hematopoéticas
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Desidratação
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
En
Revista:
Annals of Pediatric Endocrinology & Metabolism
Ano de publicação:
2015
Tipo de documento:
Article