Photodynamic Therapy for Choroidal Neovascularization Secondary to Age-Related Macular Degeneration
Journal of the Korean Ophthalmological Society
; : 789-798, 2007.
Article
em Ko
| WPRIM
| ID: wpr-9671
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE: To investigate the effects of repeated photodynamic therapy (PDT) for subfoveal choroidal neovascularization secondary to age-related macular degeneration (AMD) in Korean patients. METHODS: Clinical data of patients who were treated with repeated (3 times or more) PDT for subfoveal choroidal neovascularization secondary to AMD and followed up for more than 6 months were collected from 17 hospitals around the country. Visual outcomes at 12 and 24 months, follow-up were compared between subtypes of choroidal neovascularization. The factors related to final visual prognosis and PDT-related adverse effects were evaluated. RESULTS: 244 patients (244 eyes) were recruited (male: 60%, age: 67.7+/-9.1 years). The portion of patients with predominantly classic, minimally classic, and occult without classic choroidal neovascularization was 57%, 13%, and 24%, respectively and that of patients with visual improvements or less than moderate visual loss at 24 months follow-up were 28%, 38%, 30% and 47%, 56%, and 65%, respectively. Baseline visual acuity and age were significantly related to the final visual prognosis (p<0.05). PDT-related adverse events developed in 15 (6.1%) patients, but most were mild and transient. CONCLUSIONS: Repeated PDT for subfoveal choroidal neovascularization secondary to AMD has effects comparable to those of previous prospective, controlled trials without any significant safety concerns in Korea.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Fotoquimioterapia
/
Prognóstico
/
Acuidade Visual
/
Seguimentos
/
Corioide
/
Neovascularização de Coroide
/
Coreia (Geográfico)
/
Degeneração Macular
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Humans
País/Região como assunto:
Asia
Idioma:
Ko
Revista:
Journal of the Korean Ophthalmological Society
Ano de publicação:
2007
Tipo de documento:
Article