4-Hexylresorcinol: pharmacologic chaperone and its application for wound healing / 대한악안면성형재건외과학회지
Maxillofacial Plastic and Reconstructive Surgery
; : 5-2022.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-969132
Biblioteca responsável:
WPRO
ABSTRACT
4-Hexylresorcinol (4HR) is amphiphilic organic chemical and auto-regulator for micro-organism. As 4HR administration induces the stress on the endoplasmic reticulum, 4HR changes protein folding. The application of 4HR inhibits NF-κB signal pathway and TNF-α production. In addition, 4HR administration increases VEGF, TGF-β1, and calcification associated proteins. As a consequence, 4HR administration increases angiogenesis and bone formation in wounded area. Strong anti-inflammatory reaction and capillary regeneration in diabetic model demonstrate that 4HR can be applied on many types of surgical wound.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Inglês
Revista:
Maxillofacial Plastic and Reconstructive Surgery
Ano de publicação:
2022
Tipo de documento:
Artigo