Research progress on the immunomodulatory effects and mechanisms of trace amine-associated receptor 1 / 生理学报
Acta Physiologica Sinica
; (6): 248-254, 2023.
Article
em Zh
| WPRIM
| ID: wpr-981002
Biblioteca responsável:
WPRO
ABSTRACT
Trace amines are endogenous molecules distributed in the central nervous system and peripheral tissues that resemble common biogenic amines in terms of subcellular localization, chemical structure, and metabolism. Trace amine-associated receptor (TAAR) is a kind of evolutionarily conserved G-protein-coupled receptors in vertebrates, in which TAAR1 is a functional regulator of monoamine transmitters such as dopamine and serotonin. TAAR1 is widely considered as a potential therapeutic target for schizophrenia, depression and drug addiction. Moreover, TAAR1 is also expressed in peripheral tissues. The homeostasis imbalance of trace aminergic system can induce over-activation of peripheral immune system and central immune inflammatory response. TAAR1 modulators are becoming potential emerging drugs for the treatment of immune-related illnesses, because they may play a major role in the activation or modulation of immune response.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Aminas Biogênicas
/
Dopamina
/
Transtornos Relacionados ao Uso de Substâncias
/
Receptores Acoplados a Proteínas G
Limite:
Animals
/
Humans
Idioma:
Zh
Revista:
Acta Physiologica Sinica
Ano de publicação:
2023
Tipo de documento:
Article