Overview and prospects of an in vitro cell model for studying liver fibrosis / 中华肝脏病杂志
Chinese Journal of Hepatology
; (12): 668-672, 2023.
Article
em Zh
| WPRIM
| ID: wpr-986190
Biblioteca responsável:
WPRO
ABSTRACT
Liver fibrosis incidence and adverse outcomes are high; however, there are no known chemical drugs or biological agents that are specific and effective for treatment. The paucity of a robust and realistic in vitro model for liver fibrosis is one of the major causes hindering anti-liver fibrosis drug development. This article summarizes the latest progress in the development of in vitro cell models for liver fibrosis, with a focus based on the analysis of induction and activation of hepatic stellate cells, cell co-culture, and 3D model co-construction, as well as concurrent potential methods based on hepatic sinusoidal endothelial cell establishment.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Técnicas de Cultura de Células
/
Células Endoteliais
/
Células Estreladas do Fígado
/
Cirrose Hepática
Limite:
Humans
Idioma:
Zh
Revista:
Chinese Journal of Hepatology
Ano de publicação:
2023
Tipo de documento:
Article
País de publicação:
CHINA
/
CN
/
REPUBLIC OF CHINA