Pathogenesis of depression: focusing on protein levels and genetic abnormalities / 中华神经科杂志

ABSTRACT

Depression is a common psychiatric disorder characterized by a wide range of clinical manifestations, including depressed mood, psychomotor retardation, diminished motivation, anhedonia, despair, and even suicidality. The heterogeneity of the features of depression indicates the diversity of its pathogenesis. Protein levels and their genetic abnormalities are essential factors in the pathogenesis of depression. This review focuses on the levels and genetic abnormalities of depression-related proteins to further elaborate the pathogenesis of depression and presents current problems and challenges to provide a theoretical foundation for the development of novel antidepressant medications.