Research progress of SARS-CoV-2 main protease inhibitors / 药学学报
Acta Pharmaceutica Sinica
; (12): 2581-2600, 2023.
Article
em Zh
| WPRIM
| ID: wpr-999009
Biblioteca responsável:
WPRO
ABSTRACT
As a common protease with high similarity among coronavirus species, the main protease (Mpro) of SARS-CoV-2 is responsible for the catalytic hydrolysis of viral precursor proteins into functional proteins, which is essential for coronavirus replication and is one of the ideal targets for the development of broad-spectrum antiviral drugs. This paper reviews the main protease inhibitors of SARS-CoV-2, including their molecular structures, potencies and drug-like profiles, binding modes and structure-activity relationships, etc.
Texto completo:
1
Base de dados:
WPRIM
Idioma:
Zh
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2023
Tipo de documento:
Article
País de publicação:
CHINA
/
CN
/
REPUBLIC OF CHINA