Detalhe da pesquisa
1.
SAR towards indoline and 3-azaindoline classes of IDO1 inhibitors.
Bioorg Med Chem Lett
; 47: 128214, 2021 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34166782
2.
The synthesis of 2,3,6-trisubstituted 1-oxo-1,2-dihydroisoquinolines as potent CRTh2 antagonists.
Bioorg Med Chem Lett
; 27(23): 5344-5348, 2017 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29110986
3.
Ubiquitin-specific protease 7 inhibitors reveal a differentiated mechanism of p53-driven anti-cancer activity.
iScience
; 27(5): 109693, 2024 May 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-38689642
4.
Conformation constraint of anilides enabling the discovery of tricyclic lactams as potent MK2 non-ATP competitive inhibitors.
Bioorg Med Chem Lett
; 23(11): 3262-6, 2013 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23602398
5.
The discovery of fused oxadiazepines as gamma secretase modulators for treatment of Alzheimer's disease.
Bioorg Med Chem Lett
; 23(2): 466-71, 2013 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23253441
6.
Facile synthesis of tetracyclic azepine and oxazocine derivatives and their potential as MAPKAP-K2 (MK2) inhibitors.
Bioorg Med Chem Lett
; 22(2): 1068-72, 2012 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22182499
7.
A three-step protocol for lead optimization: quick identification of key conformational features and functional groups in the SAR studies of non-ATP competitive MK2 (MAPKAPK2) inhibitors.
Bioorg Med Chem Lett
; 22(1): 65-70, 2012 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22169260
8.
SAR studies of C2 ethers of 2H-pyrano[2,3-d]pyrimidine-2,4,7(1H,3H)-triones as nicotinic acid receptor (NAR) agonist.
Bioorg Med Chem Lett
; 22(2): 854-8, 2012 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22209457
9.
Diminishing GSH-Adduct Formation of Tricyclic Diazepine-based Mutant IDH1 Inhibitors.
ACS Med Chem Lett
; 13(4): 734-741, 2022 Apr 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35450359
10.
Discovery of fused 5,6-bicyclic heterocycles as γ-secretase modulators.
Bioorg Med Chem Lett
; 21(2): 664-9, 2011 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21195610
11.
Generation of Leads for γ-Secretase Modulation.
J Med Chem
; 63(15): 8216-8230, 2020 08 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-32786237
12.
Cochlea sparing with a stratified scheme of dose limitation employed in intensity-modulated radiotherapy for nasopharyngeal carcinoma: A dosimetry study.
Med Dosim
; 44(3): 226-232, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30268345
13.
A case-oriented web-based training system for breast cancer diagnosis.
Comput Methods Programs Biomed
; 156: 73-83, 2018 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-29428078
14.
Discovery of MK-8318, a Potent and Selective CRTh2 Receptor Antagonist for the Treatment of Asthma.
ACS Med Chem Lett
; 9(7): 679-684, 2018 Jul 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30034600
15.
The total synthesis of psymberin.
Org Lett
; 9(13): 2597-600, 2007 Jun 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-17523653
16.
Discovery of a Tetrahydrobenzisoxazole Series of γ-Secretase Modulators.
ACS Med Chem Lett
; 8(10): 1002-1006, 2017 Oct 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29057041
17.
Manipulation of N,O-nucleophilicity: efficient formation of 4-N-substituted 2,4-dihydro-3H-1,2,4-triazolin-3-ones.
Org Lett
; 6(25): 4795-8, 2004 Dec 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-15575688
18.
A case study of single-pill combination therapy: the ezetimibe/simvastatin combination for treatment of hyperlipidemia.
ChemMedChem
; 7(11): 1882-94, 2012 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-22907901
19.
Discovery of a Potent Dihydrooxadiazole Series of Non-ATP-Competitive MK2 (MAPKAPK2) Inhibitors.
ACS Med Chem Lett
; 3(2): 100-5, 2012 Feb 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900435
20.
Synthesis and SAR Studies of Fused Oxadiazines as γ-Secretase Modulators for Treatment of Alzheimer's Disease.
ACS Med Chem Lett
; 3(11): 931-5, 2012 Nov 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900409