Detalhe da pesquisa
1.
Hit to Lead optimization of a novel class of squarate-containing polo-like kinases inhibitors.
Bioorg Med Chem Lett
; 22(24): 7615-22, 2012 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23103095
2.
Discovery and SAR of substituted 3-oxoisoindoline-4-carboxamides as potent inhibitors of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer.
Bioorg Med Chem Lett
; 20(3): 1023-6, 2010 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20045315
3.
Potentiation of temozolomide cytotoxicity by poly(ADP)ribose polymerase inhibitor ABT-888 requires a conversion of single-stranded DNA damages to double-stranded DNA breaks.
Mol Cancer Res
; 6(10): 1621-9, 2008 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-18922977
4.
Isoxazolo[3,4-b]quinoline-3,4(1H,9H)-diones as unique, potent and selective inhibitors for Pim-1 and Pim-2 kinases: chemistry, biological activities, and molecular modeling.
Bioorg Med Chem Lett
; 18(19): 5206-8, 2008 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18790640
5.
Synthesis and SAR of novel, potent and orally bioavailable benzimidazole inhibitors of poly(ADP-ribose) polymerase (PARP) with a quaternary methylene-amino substituent.
Bioorg Med Chem Lett
; 18(14): 3955-8, 2008 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18586490
6.
The PARP inhibitor, ABT-888 potentiates temozolomide: correlation with drug levels and reduction in PARP activity in vivo.
Anticancer Res
; 28(5A): 2625-35, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-19035287
7.
Discovery and SAR of 2-(1-propylpiperidin-4-yl)-1H-benzimidazole-4-carboxamide: A potent inhibitor of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer.
Bioorg Med Chem
; 16(14): 6965-75, 2008 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18541433
8.
ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models.
Clin Cancer Res
; 13(9): 2728-37, 2007 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17473206
9.
Syntheses of potent, selective, and orally bioavailable indazole-pyridine series of protein kinase B/Akt inhibitors with reduced hypotension.
J Med Chem
; 50(13): 2990-3003, 2007 Jun 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-17523610
10.
Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo.
Mol Cancer Ther
; 4(6): 977-86, 2005 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-15956255
11.
Optimal classes of chemotherapeutic agents sensitized by specific small-molecule inhibitors of akt in vitro and in vivo.
Neoplasia
; 7(11): 992-1000, 2005 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-16331885
12.
Identification of novel binding interactions in the development of potent, selective 2-naphthamidine inhibitors of urokinase. Synthesis, structural analysis, and SAR of N-phenyl amide 6-substitution.
J Med Chem
; 47(2): 303-24, 2004 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-14711304
13.
Optimization of phenyl-substituted benzimidazole carboxamide poly(ADP-ribose) polymerase inhibitors: identification of (S)-2-(2-fluoro-4-(pyrrolidin-2-yl)phenyl)-1H-benzimidazole-4-carboxamide (A-966492), a highly potent and efficacious inhibitor.
J Med Chem
; 53(8): 3142-53, 2010 Apr 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-20337371
14.
Discovery of the Poly(ADP-ribose) polymerase (PARP) inhibitor 2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide (ABT-888) for the treatment of cancer.
J Med Chem
; 52(2): 514-23, 2009 Jan 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-19143569
15.
Design and synthesis of pyridine-pyrazolopyridine-based inhibitors of protein kinase B/Akt.
Bioorg Med Chem
; 15(6): 2441-52, 2007 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17258463
16.
Discovery of trans-3,4'-bispyridinylethylenes as potent and novel inhibitors of protein kinase B (PKB/Akt) for the treatment of cancer: Synthesis and biological evaluation.
Bioorg Med Chem Lett
; 16(6): 1679-85, 2006 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16403626
17.
Synthesis and structure-activity relationship of 3,4'-bispyridinylethylenes: discovery of a potent 3-isoquinolinylpyridine inhibitor of protein kinase B (PKB/Akt) for the treatment of cancer.
Bioorg Med Chem Lett
; 16(7): 2000-7, 2006 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16413780
18.
Synthesis and SAR of indazole-pyridine based protein kinase B/Akt inhibitors.
Bioorg Med Chem
; 14(20): 6832-46, 2006 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16843670
19.
Identification of a novel 3,5-disubstituted pyridine as a potent, selective, and orally active inhibitor of Akt1 kinase.
Bioorg Med Chem Lett
; 16(14): 3740-4, 2006 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16678413
20.
Discovery and SAR of oxindole-pyridine-based protein kinase B/Akt inhibitors for treating cancers.
Bioorg Med Chem Lett
; 16(13): 3424-9, 2006 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16644221