Detalhe da pesquisa
1.
19F-NMR-based determination of the absorption, metabolism and excretion of the oral phosphatidylinositol-3-kinase (PI3K) delta inhibitor leniolisib (CDZ173) in healthy volunteers.
Xenobiotica
; 49(8): 953-960, 2019 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-30215545
2.
Development of a cyclosporin A derivative with excellent anti-hepatitis C virus potency.
Bioorg Med Chem
; 26(4): 957-969, 2018 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28919180
3.
Comparison of 19F NMR and 14C Measurements for the Assessment of ADME of BYL719 (Alpelisib) in Humans.
Drug Metab Dispos
; 45(8): 900-907, 2017 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28566285
4.
Identification of Three Novel Ring Expansion Metabolites of KAE609, a New Spiroindolone Agent for the Treatment of Malaria, in Rats, Dogs, and Humans.
Drug Metab Dispos
; 44(5): 653-64, 2016 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-26921386
5.
KAE609 (Cipargamin), a New Spiroindolone Agent for the Treatment of Malaria: Evaluation of the Absorption, Distribution, Metabolism, and Excretion of a Single Oral 300-mg Dose of [14C]KAE609 in Healthy Male Subjects.
Drug Metab Dispos
; 44(5): 672-82, 2016 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-26921387
6.
Novel Concept for Super-Soft Topical Drugs: Deactivation by an Enzyme-Induced Switch into an Inactive Conformation.
ACS Med Chem Lett
; 14(6): 841-845, 2023 Jun 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37312861
7.
High-throughput synthesis provides data for predicting molecular properties and reaction success.
Sci Adv
; 9(43): eadj2314, 2023 10 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-37889964
8.
Integrated and automated high-throughput purification of libraries on microscale.
SLAS Technol
; 27(6): 350-360, 2022 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-36028206
9.
Discovery and Characterization of Clinical Candidate LXE408 as a Kinetoplastid-Selective Proteasome Inhibitor for the Treatment of Leishmaniases.
J Med Chem
; 63(19): 10773-10781, 2020 10 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32667203
10.
Micropreparative isolation and NMR structure elucidation of metabolites of the drug candidate 1-isopropyl-4-(4-isopropylphenyl)-6-(prop-2-yn-1-yloxy) quinazolin-2(1H)-one from rat bile and urine.
J Chromatogr B Analyt Technol Biomed Life Sci
; 989: 1-10, 2015 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25797717