Detalhe da pesquisa
1.
Structural and Molecular Mechanisms of Cytokine-Mediated Endocrine Resistance in Human Breast Cancer Cells.
Mol Cell
; 65(6): 1122-1135.e5, 2017 Mar 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-28306507
2.
Dual-mechanism estrogen receptor inhibitors.
Proc Natl Acad Sci U S A
; 118(35)2021 08 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-34452998
3.
Chemical systems biology reveals mechanisms of glucocorticoid receptor signaling.
Nat Chem Biol
; 17(3): 307-316, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33510451
4.
Activation of Crtc2/Creb1 in skeletal muscle enhances weight loss during intermittent fasting.
FASEB J
; 35(12): e21999, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34748223
5.
Suppression of breast cancer metastasis and extension of survival by a new antiestrogen in a preclinical model driven by mutant estrogen receptors.
Breast Cancer Res Treat
; 181(2): 297-307, 2020 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-32277377
6.
Full antagonism of the estrogen receptor without a prototypical ligand side chain.
Nat Chem Biol
; 13(1): 111-118, 2017 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27870835
7.
Unexpected equivalent potency of a constrained chromene enantiomeric pair rationalized by co-crystal structures in complex with estrogen receptor alpha.
Bioorg Med Chem Lett
; 29(7): 905-911, 2019 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30732944
8.
Tethering not required: the glucocorticoid receptor binds directly to activator protein-1 recognition motifs to repress inflammatory genes.
Nucleic Acids Res
; 45(14): 8596-8608, 2017 Aug 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-28591827
9.
Creb coactivators direct anabolic responses and enhance performance of skeletal muscle.
EMBO J
; 33(9): 1027-43, 2014 May 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-24674967
10.
Predictive features of ligand-specific signaling through the estrogen receptor.
Mol Syst Biol
; 12(4): 864, 2016 Apr 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-27107013
11.
Synthesis of novel steroidal agonists, partial agonists, and antagonists for the glucocorticoid receptor.
Bioorg Med Chem Lett
; 27(2): 347-353, 2017 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27919657
12.
Ligand-binding dynamics rewire cellular signaling via estrogen receptor-α.
Nat Chem Biol
; 9(5): 326-32, 2013 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-23524984
13.
Erratum: Full antagonism of the estrogen receptor without a prototypical ligand side chain.
Nat Chem Biol
; 13(6): 691, 2017 05 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-28514419
14.
Corrigendum: Full antagonism of the estrogen receptor without a prototypical ligand side chain.
Nat Chem Biol
; 13(6): 691, 2017 05 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-28514424
15.
Asymmetric Allostery in Estrogen Receptor-α Homodimers Drives Responses to the Ensemble of Estrogens in the Hormonal Milieu.
bioRxiv
; 2024 Apr 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38645081
16.
Skeletal Muscle Endogenous Estrogen Production Ameliorates the Metabolic Consequences of a High-Fat Diet in Male Mice.
Endocrinology
; 164(8)2023 06 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-37421340
17.
Design, synthesis, biological evaluation and crystal structure determination of dual modulators of carbonic anhydrases and estrogen receptors.
Eur J Med Chem
; 246: 115011, 2023 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36516582
18.
Coupling of receptor conformation and ligand orientation determine graded activity.
Nat Chem Biol
; 6(11): 837-43, 2010 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-20924370
19.
Bicyclic core estrogens as full antagonists: synthesis, biological evaluation and structure-activity relationships of estrogen receptor ligands based on bridged oxabicyclic core arylsulfonamides.
Org Biomol Chem
; 10(43): 8692-700, 2012 Nov 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-23033157
20.
Hydroxychloroquine blocks SARS-CoV-2 entry into the endocytic pathway in mammalian cell culture.
Commun Biol
; 5(1): 958, 2022 09 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36104427