Detalhe da pesquisa
1.
Structure-Based Design of AG-946, a Pyruvate Kinase Activator.
ChemMedChem
; 19(5): e202300559, 2024 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38109501
2.
Leveraging Structure-Based Drug Design to Identify Next-Generation MAT2A Inhibitors, Including Brain-Penetrant and Peripherally Efficacious Leads.
J Med Chem
; 65(6): 4600-4615, 2022 03 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-35293760
3.
Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous MTAP Deletion.
J Med Chem
; 64(8): 4430-4449, 2021 04 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33829783
4.
High-throughput mutagenesis reveals unique structural features of human ADAR1.
Nat Commun
; 11(1): 5130, 2020 10 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33046702
5.
Selective Vulnerability to Pyrimidine Starvation in Hematologic Malignancies Revealed by AG-636, a Novel Clinical-Stage Inhibitor of Dihydroorotate Dehydrogenase.
Mol Cancer Ther
; 19(12): 2502-2515, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33082276
6.
Vorasidenib (AG-881): A First-in-Class, Brain-Penetrant Dual Inhibitor of Mutant IDH1 and 2 for Treatment of Glioma.
ACS Med Chem Lett
; 11(2): 101-107, 2020 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-32071674
7.
Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase.
Nat Commun
; 10(1): 97, 2019 01 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30626872
8.
Distinct Hepatic PKA and CDK Signaling Pathways Control Activity-Independent Pyruvate Kinase Phosphorylation and Hepatic Glucose Production.
Cell Rep
; 29(11): 3394-3404.e9, 2019 12 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31825824
9.
A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition.
Nat Commun
; 10(1): 96, 2019 01 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30626880
10.
Lateral energy transfer model for adjacent light-harvesting antennae rods of C-phycocyanins.
Biochim Biophys Acta
; 1757(3): 161-5, 2006 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-16626627
11.
Crystal structure of shikimate 5-dehydrogenase (SDH) bound to NADP: insights into function and evolution.
Structure
; 11(8): 1005-13, 2003 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-12906831
12.
Crystal structure of human GDF11.
Acta Crystallogr F Struct Biol Commun
; 72(Pt 3): 160-4, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-26919518
13.
Outcome of the First wwPDB/CCDC/D3R Ligand Validation Workshop.
Structure
; 24(4): 502-508, 2016 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-27050687
14.
Synthesis, SAR, and series evolution of novel oxadiazole-containing 5-lipoxygenase activating protein inhibitors: discovery of 2-[4-(3-{(r)-1-[4-(2-amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]-N,N-dimethyl-acetamide (BI 665915).
J Med Chem
; 58(4): 1669-90, 2015 Feb 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-25671290
15.
Integrated strategies for identifying leads that target the NS3 helicase of the hepatitis C virus.
J Med Chem
; 57(5): 2074-90, 2014 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24467709
16.
Discovery of potent, selective chymase inhibitors via fragment linking strategies.
J Med Chem
; 56(11): 4465-81, 2013 Jun 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-23659209
17.
Fragment-based discovery of indole inhibitors of matrix metalloproteinase-13.
J Med Chem
; 54(23): 8174-87, 2011 Dec 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-22017539
18.
Correction to Fragment-Based Discovery of Indole Inhibitors of Matrix Metalloproteinase-13.
J Med Chem
; 58(15): 6318, 2015 Aug 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-26214135
19.
Structural basis for autoinhibition and mutational activation of eukaryotic initiation factor 2alpha protein kinase GCN2.
J Biol Chem
; 280(32): 29289-99, 2005 Aug 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-15964839
20.
Role of a two-residue spacer in an alpha,beta-Didehydrophenylalanine containing hexapeptide: crystal and solution structure of Boc-val-deltaPhe-Leu-Ala-deltaPhe-Ala-OMe.
J Pept Sci
; 9(1): 54-63, 2003 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-12587883