Detalhe da pesquisa
1.
Potentiation of rifampin activity in a mouse model of tuberculosis by activation of host transcription factor EB.
PLoS Pathog
; 16(6): e1008567, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32574211
2.
Evaluation of Alitretinoin for the Treatment of Mycosis Fungoides and Sézary Syndrome.
Dermatology
; 237(3): 479-485, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33429396
3.
Investigating Sulfoxide-to-Sulfone Conversion as a Prodrug Strategy for a Phosphatidylinositol 4-Kinase Inhibitor in a Humanized Mouse Model of Malaria.
Antimicrob Agents Chemother
; 62(12)2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30249687
4.
UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria.
Antimicrob Agents Chemother
; 62(9)2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29941635
5.
Potent Plasmodium falciparum gametocytocidal compounds identified by exploring the kinase inhibitor chemical space for dual active antimalarials.
J Antimicrob Chemother
; 73(5): 1279-1290, 2018 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29420756
6.
Synthesis and biological evaluation of aryl-oxadiazoles as inhibitors of Mycobacterium tuberculosis.
Bioorg Med Chem Lett
; 28(10): 1758-1764, 2018 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29680666
7.
Aminopyrazolo[1,5-a]pyrimidines as potential inhibitors of Mycobacterium tuberculosis: Structure activity relationships and ADME characterization.
Bioorg Med Chem
; 23(22): 7240-50, 2015 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26522089
8.
Erratum for Brunschwig et al., "UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria".
Antimicrob Agents Chemother
; 62(11)2018 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30355750
9.
Fast in vitro methods to determine the speed of action and the stage-specificity of anti-malarials in Plasmodium falciparum.
Malar J
; 12: 424, 2013 Nov 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-24237770
10.
The synthesis and preclinical evaluation in rhesus monkey of [¹8F]MK-6577 and [¹¹C]CMPyPB glycine transporter 1 positron emission tomography radiotracers.
Synapse
; 65(4): 261-70, 2011 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-20687108
11.
Benzotriazinone and benzopyrimidinone derivatives as potent positive allosteric AMPA receptor modulators.
Bioorg Med Chem Lett
; 21(20): 6170-5, 2011 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21889339
12.
Benzobistriazinones and related heterocyclic ring systems as potent, orally bioavailable positive allosteric AMPA receptor modulators.
Bioorg Med Chem Lett
; 21(24): 7455-9, 2011 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22056742
13.
Benzoheterocyclic Oxime Carbamates Active against Mycobacterium tuberculosis: Synthesis, Structure-Activity Relationship, Metabolism, and Biology Triaging.
J Med Chem
; 64(13): 9444-9457, 2021 07 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34138573
14.
Identification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite Plasmodium falciparum and Optimization Efforts.
J Med Chem
; 64(4): 2291-2309, 2021 02 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-33573376
15.
Lerisetron Analogues with Antimalarial Properties: Synthesis, Structure-Activity Relationship Studies, and Biological Assessment.
ACS Omega
; 5(12): 6967-6982, 2020 Mar 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-32258933
16.
Identification of 2,4-Disubstituted Imidazopyridines as Hemozoin Formation Inhibitors with Fast-Killing Kinetics and In Vivo Efficacy in the Plasmodium falciparum NSG Mouse Model.
J Med Chem
; 63(21): 13013-13030, 2020 11 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33103428
17.
Optimisation of a series of potent, selective and orally bioavailable GlyT1 inhibitors.
Bioorg Med Chem Lett
; 19(8): 2235-9, 2009 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19318248
18.
Antimalarial Lead-Optimization Studies on a 2,6-Imidazopyridine Series within a Constrained Chemical Space To Circumvent Atypical Dose-Response Curves against Multidrug Resistant Parasite Strains.
J Med Chem
; 61(20): 9371-9385, 2018 10 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-30256636
19.
Identification, Characterization, and Optimization of 2,8-Disubstituted-1,5-naphthyridines as Novel Plasmodium falciparum Phosphatidylinositol-4-kinase Inhibitors with in Vivo Efficacy in a Humanized Mouse Model of Malaria.
J Med Chem
; 61(13): 5692-5703, 2018 07 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29889526
20.
Identification of Fast-Acting 2,6-Disubstituted Imidazopyridines That Are Efficacious in the in Vivo Humanized Plasmodium falciparum NODscidIL2Rγ null Mouse Model of Malaria.
J Med Chem
; 61(9): 4213-4227, 2018 05 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29665687