Detalhe da pesquisa
1.
Dupilumab efficacy and safety in adults with uncontrolled persistent asthma despite use of medium-to-high-dose inhaled corticosteroids plus a long-acting ß2 agonist: a randomised double-blind placebo-controlled pivotal phase 2b dose-ranging trial.
Lancet
; 388(10039): 31-44, 2016 Jul 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27130691
2.
Efficacy and safety of dupilumab in adults with moderate-to-severe atopic dermatitis inadequately controlled by topical treatments: a randomised, placebo-controlled, dose-ranging phase 2b trial.
Lancet
; 387(10013): 40-52, 2016 Jan 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-26454361
3.
Dupilumab therapy provides clinically meaningful improvement in patient-reported outcomes (PROs): A phase IIb, randomized, placebo-controlled, clinical trial in adult patients with moderate to severe atopic dermatitis (AD).
J Am Acad Dermatol
; 75(3): 506-515, 2016 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-27268421
4.
CXCR2 Antagonist MK-7123. A Phase 2 Proof-of-Concept Trial for Chronic Obstructive Pulmonary Disease.
Am J Respir Crit Care Med
; 191(9): 1001-11, 2015 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25695403
5.
Effect of Subcutaneous Dupilumab on Nasal Polyp Burden in Patients With Chronic Sinusitis and Nasal Polyposis: A Randomized Clinical Trial.
JAMA
; 315(5): 469-79, 2016 Feb 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-26836729
6.
Lipoxin generation is related to soluble epoxide hydrolase activity in severe asthma.
Am J Respir Crit Care Med
; 190(8): 886-97, 2014 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25162465
7.
Designing clinical trials to address the needs of childhood and adult asthma: the National Heart, Lung, and Blood Institute's AsthmaNet.
J Allergy Clin Immunol
; 133(1): 34-8.e1, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24369797
8.
Leukotriene B4 receptor 1 is differentially expressed on peripheral T cells of steroid-sensitive and -resistant asthmatics.
Ann Allergy Asthma Immunol
; 112(3): 211-216.e1, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24428972
9.
The effects of airway microbiome on corticosteroid responsiveness in asthma.
Am J Respir Crit Care Med
; 188(10): 1193-201, 2013 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24024497
10.
P2X7-regulated protection from exacerbations and loss of control is independent of asthma maintenance therapy.
Am J Respir Crit Care Med
; 187(1): 28-33, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23144325
11.
Clinical phenotypes of chronic obstructive pulmonary disease and asthma: recent advances.
J Allergy Clin Immunol
; 131(3): 627-34; quiz 635, 2013 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-23360757
12.
Obesity impairs apoptotic cell clearance in asthma.
J Allergy Clin Immunol
; 131(4): 1041-7, 1047.e1-3, 2013 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-23154082
13.
Predictors of response to tiotropium versus salmeterol in asthmatic adults.
J Allergy Clin Immunol
; 132(5): 1068-1074.e1, 2013 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-24084072
14.
Effect of vitamin D3 on asthma treatment failures in adults with symptomatic asthma and lower vitamin D levels: the VIDA randomized clinical trial.
JAMA
; 311(20): 2083-91, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24838406
15.
Tiotropium bromide step-up therapy for adults with uncontrolled asthma.
N Engl J Med
; 363(18): 1715-26, 2010 Oct 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-20979471
16.
A large subgroup of mild-to-moderate asthma is persistently noneosinophilic.
Am J Respir Crit Care Med
; 185(6): 612-9, 2012 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22268133
17.
Asthma outcomes: symptoms.
J Allergy Clin Immunol
; 129(3 Suppl): S124-35, 2012 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-22386505
18.
Impact of race on asthma treatment failures in the asthma clinical research network.
Am J Respir Crit Care Med
; 184(11): 1247-53, 2011 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21885625
19.
Airway microbiota and bronchial hyperresponsiveness in patients with suboptimally controlled asthma.
J Allergy Clin Immunol
; 127(2): 372-381.e1-3, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-21194740
20.
Comparison of physician-, biomarker-, and symptom-based strategies for adjustment of inhaled corticosteroid therapy in adults with asthma: the BASALT randomized controlled trial.
JAMA
; 308(10): 987-97, 2012 Sep 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-22968888