Detalhe da pesquisa
1.
From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease.
Cell
; 184(24): 5886-5901.e22, 2021 11 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-34822784
2.
The C-terminus of the prototypical M2 muscarinic receptor localizes to the mitochondria and regulates cell respiration under stress conditions.
PLoS Biol
; 22(4): e3002582, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38683874
3.
Combinatorial expression of GPCR isoforms affects signalling and drug responses.
Nature
; 587(7835): 650-656, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33149304
4.
The M1 muscarinic receptor is present in situ as a ligand-regulated mixture of monomers and oligomeric complexes.
Proc Natl Acad Sci U S A
; 119(24): e2201103119, 2022 06 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35671422
5.
G protein-receptor kinases 5/6 are the key regulators of G protein-coupled receptor 35-arrestin interactions.
J Biol Chem
; 299(10): 105218, 2023 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-37660910
6.
Inhibition of neuroinflammatory nitric oxide signaling suppresses glycation and prevents neuronal dysfunction in mouse prion disease.
Proc Natl Acad Sci U S A
; 118(10)2021 03 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33653950
7.
Biased M1 muscarinic receptor mutant mice show accelerated progression of prion neurodegenerative disease.
Proc Natl Acad Sci U S A
; 118(50)2021 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-34893539
8.
Agonist-induced phosphorylation of orthologues of the orphan receptor GPR35 functions as an activation sensor.
J Biol Chem
; 298(3): 101655, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35101446
9.
Selective phosphorylation of threonine residues defines GPR84-arrestin interactions of biased ligands.
J Biol Chem
; 298(5): 101932, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35427647
10.
Biased M1-muscarinic-receptor-mutant mice inform the design of next-generation drugs.
Nat Chem Biol
; 16(3): 240-249, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-32080630
11.
ß-Arrestin biosensors reveal a rapid, receptor-dependent activation/deactivation cycle.
Nature
; 531(7596): 661-4, 2016 Mar 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-27007855
12.
Crystal structure of the M5 muscarinic acetylcholine receptor.
Proc Natl Acad Sci U S A
; 116(51): 26001-26007, 2019 12 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-31772027
13.
How Arrestins and GRKs Regulate the Function of Long Chain Fatty Acid Receptors.
Int J Mol Sci
; 23(20)2022 Oct 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-36293091
14.
Chemogenetics defines receptor-mediated functions of short chain free fatty acids.
Nat Chem Biol
; 15(5): 489-498, 2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30992568
15.
Author Correction: Combinatorial expression of GPCR isoforms affects signalling and drug responses.
Nature
; 588(7838): E24, 2020 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-33244189
16.
Receptor selectivity between the G proteins Gα12 and Gα13 is defined by a single leucine-to-isoleucine variation.
FASEB J
; 33(4): 5005-5017, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30601679
17.
Design, Synthesis, and Evaluation of a Diazirine Photoaffinity Probe for Ligand-Based Receptor Capture Targeting G Protein-Coupled Receptors.
Mol Pharmacol
; 95(2): 196-209, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30514721
18.
Design of Next-Generation G Protein-Coupled Receptor Drugs: Linking Novel Pharmacology and In Vivo Animal Models.
Annu Rev Pharmacol Toxicol
; 56: 535-59, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-26738479
19.
Mapping physiological G protein-coupled receptor signaling pathways reveals a role for receptor phosphorylation in airway contraction.
Proc Natl Acad Sci U S A
; 113(16): 4524-9, 2016 Apr 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-27071102
20.
Assessment of the Molecular Mechanisms of Action of Novel 4-Phenylpyridine-2-One and 6-Phenylpyrimidin-4-One Allosteric Modulators at the M1 Muscarinic Acetylcholine Receptors.
Mol Pharmacol
; 94(1): 770-783, 2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29691279