Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Resultados 1 - 20 de 45
Filtrar
1.
Semin Speech Lang ; 45(3): 242-261, 2024 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-38574758

RESUMEN

To better understand speech-language pathologists' (SLPs') pre-service and in-service training experiences in literacy and the relationship between their literacy training experiences and current practice, self-efficacy, and beliefs regarding their roles in literacy assessment and treatment, a web-based survey of SLPs was conducted (n = 444). Responses revealed that 60% of respondents completed at least one literacy course in their graduate programs: 55% took courses that embedded content in literacy assessment or treatment, and 23% took courses dedicated to literacy. These results varied based on the decade of graduation. Although 73.5% of respondents felt that their graduate programs trained them well or very well to assess and treat spoken language, only 8.5% felt the same about literacy. Most respondents (80%) reported completing in-service literacy training, and 89% reported wanting more literacy training. Completion of in-service training was positively, significantly related to respondents' current literacy-related clinical practice, self-efficacy, and beliefs regarding their roles; however, pre-service literacy training was not significantly related to any of these. Though in-service training appears to play a role in helping SLPs deliver literacy services, more emphasis on increasing the quantity and quality of pre-service and in-service training in the assessment and treatment of literacy is needed.


Asunto(s)
Alfabetización , Patología del Habla y Lenguaje , Patología del Habla y Lenguaje/educación , Humanos , Estados Unidos , Masculino , Femenino , Autoeficacia , Adulto , Encuestas y Cuestionarios , Persona de Mediana Edad , Capacitación en Servicio
2.
J Appl Res Intellect Disabil ; 37(3): e13222, 2024 May.
Artículo en Inglés | MEDLINE | ID: mdl-38494739

RESUMEN

BACKGROUND: During the COVID-19 pandemic, the United States' Centers for Disease Control and Prevention (CDC) created guidance documents that were too complex to be read and understood by the majority of adults with intellectual and developmental disabilities who often read at or below a third-grade reading level. This study explored the extent to which these adults could read and understand CDC documents simplified using Minimised Text Complexity Guidelines. METHOD: This study involved 20 participants, 18-48 years of age. Participants read texts and responded to multiple-choice items and open-ended questions to gather information about how they interacted with and understood the texts. RESULTS: The results provide initial evidence that the Minimised Text Complexity Guidelines resulted in texts that participants could read and understand. CONCLUSION: Implications for increasing the accessibility of public health information so that it can be read and understood by adults with extremely low literacy skills are discussed.


Asunto(s)
COVID-19 , Discapacidad Intelectual , Adulto , Humanos , Comprensión , Discapacidades del Desarrollo , Pandemias/prevención & control
3.
Augment Altern Commun ; 40(2): 69-73, 2024 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-38487933

RESUMEN

On February 2 2023, one of the guiding lights in the field of augmentative and alternative communication (AAC) for more than four decades, David E. Yoder, passed away at the age of 90. A voracious reader and gifted storyteller, David was particularly fond of a quote from George Bernard Shaw's Back to Methuselah, "You see things; and you say 'Why?' but I dream things that never were; and I say 'Why not?'" That vision led him to take on multiple leadership roles and influence the field of AAC in multiple ways. He played a pivotal role in establishing both the International Society for Augmentative and Alternative Communication (ISAAC) and the United States Society for Augmentative and Alternative Communication (USSAAC). Additionally, he chaired the panel for the National Institute on Disability and Rehabilitation Research (NIDRR)'s inaugural Consensus Validation Conference on AAC, advocated for the American Speech-Language-Hearing Association to recognize AAC within the profession's scope of practice, and served as the first editor for the Augmentative and Alternative Communication journal. In this tribute, we describe David's diverse and unique contributions to improving the lives of people with communication challenges with a focus on some of his central insights and actions.


Asunto(s)
Equipos de Comunicación para Personas con Discapacidad , Equipos de Comunicación para Personas con Discapacidad/historia , Humanos , Historia del Siglo XXI , Historia del Siglo XX , Estados Unidos , Trastornos de la Comunicación/rehabilitación , Trastornos de la Comunicación/historia
4.
Augment Altern Commun ; 39(3): 146-156, 2023 09.
Artículo en Inglés | MEDLINE | ID: mdl-36598354

RESUMEN

The COVID-19 pandemic required many speech-language pathologists (SLPs) to transition to teletherapy service delivery. This study was designed to explore the experiences and perceptions of SLPs who made this transition with children with disabilities who used aided augmentative and alternative communication (AAC). Semi-structured interviews were conducted virtually with 10 SLPs who provided regular teletherapy services to children who used AAC during but not before the pandemic. Interview transcripts were analyzed thematically using immersion, reduction, and constant comparison to understand SLP experiences and perceptions individually and across the group. Results reveal that despite the challenges faced transitioning to teletherapy, there were benefits. Furthermore, many of the participating SLPs developed successful strategies and solutions for the challenges they faced. Participants in this study highlighted the unique and important role that caregivers and parents played in the success of the teletherapy they provided. This study suggests that SLPs, caregivers, and children demonstrated resilience in the face of a large-scale, unforeseen change. SLPs consistently reported the ability to maintain continuity of care during a stressful transition period, while meeting the unique needs of the children who used AAC they served.


Asunto(s)
COVID-19 , Equipos de Comunicación para Personas con Discapacidad , Trastornos de la Comunicación , Patología del Habla y Lenguaje , Niño , Humanos , Pandemias , Patólogos , Habla
5.
J Deaf Stud Deaf Educ ; 26(1): 112-129, 2021 01 01.
Artículo en Inglés | MEDLINE | ID: mdl-32942297

RESUMEN

Spelling in writing samples was compared between children who are hard of hearing (HH) (n = 142) and their peers with typical hearing (TH) (n = 72) in second and fourth grade. The same analyses were then conducted comparing groups of children who are HH with different levels of aided audibility. Compared to children with TH, children who are HH produced fewer misspelled words (p = .041, d = .42) at second grade but performed similarly in fourth grade (p = .943, d = .02). Compared to peers with TH, children who are HH demonstrated similar distributions of errors in roots but some differences in the distribution of errors for affixes. Different levels of aided audibility among children who are HH were not associated with significant differences in spelling accuracy at both grades. However, second-grade children with poorer aided audibility produced significantly more phonological omissions (p = .005, r = .32) and orthographic consonant errors for monomorphemic words (p = .001, r = .37), as well as more orthographic consonant errors for and affixes (p = .015, r = .28).


Asunto(s)
Audífonos , Pérdida Auditiva , Niño , Audición , Humanos , Lenguaje , Desarrollo del Lenguaje
6.
Proc Natl Acad Sci U S A ; 114(12): 3085-3090, 2017 03 21.
Artículo en Inglés | MEDLINE | ID: mdl-28265087

RESUMEN

Active-learning pedagogies have been repeatedly demonstrated to produce superior learning gains with large effect sizes compared with lecture-based pedagogies. Shifting large numbers of college science, technology, engineering, and mathematics (STEM) faculty to include any active learning in their teaching may retain and more effectively educate far more students than having a few faculty completely transform their teaching, but the extent to which STEM faculty are changing their teaching methods is unclear. Here, we describe the development and application of the machine-learning-derived algorithm Decibel Analysis for Research in Teaching (DART), which can analyze thousands of hours of STEM course audio recordings quickly, with minimal costs, and without need for human observers. DART analyzes the volume and variance of classroom recordings to predict the quantity of time spent on single voice (e.g., lecture), multiple voice (e.g., pair discussion), and no voice (e.g., clicker question thinking) activities. Applying DART to 1,486 recordings of class sessions from 67 courses, a total of 1,720 h of audio, revealed varied patterns of lecture (single voice) and nonlecture activity (multiple and no voice) use. We also found that there was significantly more use of multiple and no voice strategies in courses for STEM majors compared with courses for non-STEM majors, indicating that DART can be used to compare teaching strategies in different types of courses. Therefore, DART has the potential to systematically inventory the presence of active learning with ∼90% accuracy across thousands of courses in diverse settings with minimal effort.


Asunto(s)
Aprendizaje Basado en Problemas/normas , Ciencia/educación , Enseñanza/normas , Humanos , Sonido , Estudiantes , Tecnología , Universidades/normas
7.
Augment Altern Commun ; 35(2): 120-131, 2019 06.
Artículo en Inglés | MEDLINE | ID: mdl-31032648

RESUMEN

Transactional theories of communication development focus on the interplay among child, caregiver, and environmental variables. Typically, this interplay involves symmetry between receptive and expressive modes (i.e., speech), but is asymmetrical for children with complex communication needs who hear speech but use graphic symbols expressively. Aided input, during which a communication partner points to graphic symbols while talking, may increase symmetry, but it is challenging to determine which words to represent with graphic symbols to ensure adequate aided input is provided. In this study, secondary analysis of transcripts of 16 mothers who interacted with their children with typical development across six time points (between 9 and 15 months) revealed 267 words that comprised 80% of the 257,480 words the mothers used. This list of words that mothers used most frequently was compared to three existing lists of the expressive vocabulary used most frequently by 65 toddlers and preschoolers with typical development, indicating substantial overlap. The results suggest that there is a common set of frequently occurring words that mothers use in their daily interactions with infants and toddlers, and that these same words also comprise a significant proportion of the words most frequently used by young children. Implications for representing these frequently occurring words with graphic symbols on the communication systems of children with complex communication needs are discussed.


Asunto(s)
Equipos de Comunicación para Personas con Discapacidad , Relaciones Madre-Hijo , Vocabulario , Preescolar , Femenino , Humanos , Lactante , Masculino
8.
J Deaf Stud Deaf Educ ; 24(1): 41-53, 2019 01 01.
Artículo en Inglés | MEDLINE | ID: mdl-30215769

RESUMEN

This study examines the spelling of nine elementary school children with cochlear implants (CIs) who use spoken language, and compares their performance with children who have typical hearing and children who are hard of hearing (HH). Compared to children with typical hearing, children with CIs did not produce a significantly different percentage of misspelled words (p = 0.431, d = 0.38), but their spelling errors comprised significantly lower percentages of homophone substitutions (p = 0.019, r = 0.61) and legal vowel errors (p = 0.011, r = 0.61). Children with CIs and children who are HH did not produce a significantly different percentage of misspelled words (p = 0.521, d = 0.31) or a significantly different distribution of categorical spelling errors. Results suggest that children with CIs utilize similar linguistic strategies as their peers who are HH but different strategies than peers with typical hearing when attempting to spell unfamiliar words.


Asunto(s)
Implantes Cocleares/psicología , Pérdida Auditiva/psicología , Lenguaje , Multilingüismo , Factores de Edad , Niño , Preescolar , Femenino , Humanos , Masculino , Personas con Deficiencia Auditiva/psicología
9.
Am J Respir Crit Care Med ; 194(8): 1015-1025, 2016 10 15.
Artículo en Inglés | MEDLINE | ID: mdl-27739895

RESUMEN

BACKGROUND: Many advances in health care fail to reach patients. Implementation science is the study of novel approaches to mitigate this evidence-to-practice gap. METHODS: The American Thoracic Society (ATS) created a multidisciplinary ad hoc committee to develop a research statement on implementation science in pulmonary, critical care, and sleep medicine. The committee used an iterative consensus process to define implementation science and review the use of conceptual frameworks to guide implementation science for the pulmonary, critical care, and sleep community and to explore how professional medical societies such as the ATS can promote implementation science. RESULTS: The committee defined implementation science as the study of the mechanisms by which effective health care interventions are either adopted or not adopted in clinical and community settings. The committee also distinguished implementation science from the act of implementation. Ideally, implementation science should include early and continuous stakeholder involvement and the use of conceptual frameworks (i.e., models to systematize the conduct of studies and standardize the communication of findings). Multiple conceptual frameworks are available, and we suggest the selection of one or more frameworks on the basis of the specific research question and setting. Professional medical societies such as the ATS can have an important role in promoting implementation science. Recommendations for professional societies to consider include: unifying implementation science activities through a single organizational structure, linking front-line clinicians with implementation scientists, seeking collaborations to prioritize and conduct implementation science studies, supporting implementation science projects through funding opportunities, working with research funding bodies to set the research agenda in the field, collaborating with external bodies responsible for health care delivery, disseminating results of implementation science through scientific journals and conferences, and teaching the next generation about implementation science through courses and other media. CONCLUSIONS: Implementation science plays an increasingly important role in health care. Through support of implementation science, the ATS and other professional medical societies can work with other stakeholders to lead this effort.


Asunto(s)
Cuidados Críticos , Neumología , Medicina del Sueño , Investigación Biomédica Traslacional , Cuidados Críticos/normas , Difusión de Innovaciones , Humanos , Enfermedades Pulmonares/terapia , Política Organizacional , Neumología/normas , Medicina del Sueño/normas , Trastornos del Sueño-Vigilia/terapia , Sociedades Médicas/normas , Investigación Biomédica Traslacional/normas
10.
J Deaf Stud Deaf Educ ; 22(1): 35-48, 2017 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-27599868

RESUMEN

The present study describes the characteristics of students in Grades 3-12 with significant cognitive disabilities (SCD) and known hearing loss. The study analyzed results of a survey of teachers of students with SCD (n = 38,367) who were slated to participate in an alternate assessment based on alternate achievement standards in 14 states in the United States. Analysis revealed similar profiles in academic achievement and symbolic language use combined with an increased incidence of additional sensory impairments among students with SCD and known hearing loss compared to their peers without known hearing loss. Results suggest that hearing loss may be underidentified and underserved among students with SCD and point to the need for improved hearing screenings and evaluations combined with services delivered by teams that follow a model of interprofessional practice.


Asunto(s)
Trastornos del Conocimiento/etiología , Pérdida Auditiva/psicología , Adolescente , Niño , Trastornos del Conocimiento/epidemiología , Comunicación , Dislexia/epidemiología , Dislexia/etiología , Educación de Personas con Discapacidad Auditiva/estadística & datos numéricos , Educación Especial/estadística & datos numéricos , Femenino , Pérdida Auditiva/epidemiología , Humanos , Lenguaje , Trastornos del Lenguaje/epidemiología , Trastornos del Lenguaje/etiología , Alfabetización/psicología , Masculino , Lectura , Estudiantes , Estados Unidos/epidemiología , Escritura
11.
Augment Altern Commun ; 32(3): 187-97, 2016 09.
Artículo en Inglés | MEDLINE | ID: mdl-27487315

RESUMEN

Understanding the characteristics of students with complex communication needs and significant cognitive disabilities is an important first step toward creating the kinds of supports and services required to help them successfully access the general education curriculum, achieve grade-level standards, and improve overall communication competence. The First Contact Survey was designed to collect important information about students with significant cognitive disabilities who were eligible to take the Dynamic Learning Maps™ (DLM(®)) alternate assessment based on alternate achievement standards. From November 2012-May 2013, the survey was used to gather information regarding more than 44,787 students. At that time, the goal was to use the data to inform the development of the DLM assessment. Although the survey includes a wealth of information regarding this large sample of students, the reanalysis of the data reported in the current study focused on the motor, sensory, language, reading, and writing skills of students with significant cognitive disabilities, based on their speech production abilities. Significant differences were identified across each of the domains between students who do and do not use speech with or without aided augmentative and alternative communication.


Asunto(s)
Disfunción Cognitiva/epidemiología , Equipos de Comunicación para Personas con Discapacidad , Trastornos de la Comunicación/rehabilitación , Educación Especial , Maestros , Adolescente , Síntomas Afectivos/epidemiología , Trastorno Autístico/epidemiología , Niño , Trastornos de la Comunicación/epidemiología , Comorbilidad , Niños con Discapacidad , Femenino , Pérdida Auditiva/epidemiología , Humanos , Discapacidad Intelectual/epidemiología , Trastornos del Desarrollo del Lenguaje/epidemiología , Discapacidades para el Aprendizaje/epidemiología , Masculino , Trastornos de la Destreza Motora/epidemiología , Estudiantes , Encuestas y Cuestionarios , Estados Unidos/epidemiología , Trastornos de la Visión/epidemiología
12.
Lang Speech Hear Serv Sch ; 55(3): 741-755, 2024 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-38573159

RESUMEN

PURPOSE: This study examined the clinical practice, self-efficacy, and beliefs about assessing and treating written language among speech-language pathologists (SLPs) working with school-aged clients (aged 5-21 years) in school and nonschool settings in the United States. METHOD: A survey was completed by a nationwide sample of 344 SLPs working with school-aged clients in the United States. Statistical analyses were conducted to determine differences between (a) SLPs' self-efficacy in assessing and treating spoken versus written language and (b) school-based and non-school-based SLPs' clinical practice, self-efficacy, and beliefs about their roles with written language. RESULTS: All respondents reported significantly lower rates of self-efficacy in assessing and treating written language compared to spoken language, and their self-efficacy had a significant, positive relationship with the amount of clinical time devoted to written language. School-based SLPs devoted a significantly lower percentage of clinical time to written language, had significantly lower self-efficacy in addressing written language, and had lower rates of agreement on statements about their roles and responsibilities with written language compared to non-school-based SLPs. These differences were not found with spoken language. The most prevalent written language needs on respondents' workloads were reported as written expression (69.3%) and reading comprehension (66%). CONCLUSIONS: School-based and non-school-based SLPs report different levels of clinical time devoted to written language, self-efficacy in addressing written language, and beliefs about their roles in addressing written language. There is a need to investigate the reasons for these differences and the potential impact of preservice and in-service training in ameliorating them. SUPPLEMENTAL MATERIAL: https://doi.org/10.23641/asha.25511047.


Asunto(s)
Autoeficacia , Patología del Habla y Lenguaje , Humanos , Patología del Habla y Lenguaje/métodos , Niño , Adolescente , Masculino , Femenino , Adulto Joven , Estados Unidos , Preescolar , Escritura , Encuestas y Cuestionarios , Actitud del Personal de Salud , Persona de Mediana Edad , Lenguaje , Adulto
13.
BMC Public Health ; 13: 300, 2013 Apr 04.
Artículo en Inglés | MEDLINE | ID: mdl-23556505

RESUMEN

BACKGROUND: Weight gain during young adulthood is common and is associated with increased cardiovascular risk. Preventing this weight gain from occurring may be critical to improving long-term health. Few studies have focused on weight gain prevention, and these studies have had limited success. SNAP (Study of Novel Approaches to Weight Gain Prevention) is an NIH-funded randomized clinical trial examining the efficacy of two novel self-regulation approaches to weight gain prevention in young adults compared to a minimal treatment control. The interventions focus on either small, consistent changes in eating and exercise behaviors, or larger, periodic changes to buffer against expected weight gains. METHODS/DESIGN: SNAP targets recruitment of six hundred young adults (18-35 years) with a body mass index between 21.0-30.0 kg/m2, who will be randomly assigned with equal probability to: (1) minimal intervention control; (2) self-regulation with Small Changes; or (3) self-regulation with Large Changes. Both interventions receive 8 weekly face-to-face group sessions, followed by 2 monthly sessions, with two 4-week refresher courses in each of subsequent years. Participants are instructed to report weight via web at least monthly thereafter, and receive monthly email feedback. Participants in Small Changes are taught to make small daily changes (~100 calorie changes) in how much or what they eat and to accumulate 2000 additional steps per day. Participants in Large Changes are taught to create a weight loss buffer of 5-10 pounds once per year to protect against anticipated weight gains. Both groups are encouraged to self-weigh daily and taught a self-regulation color zone system that specifies action depending on weight gain prevention success. Individualized treatment contact is offered to participants who report weight gains. Participants are assessed at baseline, 4 months, and then annually. The primary outcome is weight gain over an average of 3 years of follow-up; secondary outcomes include diet and physical activity behaviors, psychosocial measures, and cardiovascular disease risk factors. DISCUSSION: SNAP is unique in its focus on weight gain prevention in young adulthood. The trial will provide important information about whether either or both of these novel interventions are effective in preventing weight gain. TRIAL REGISTRATION: ClinicalTrials.gov, NCT01183689.


Asunto(s)
Índice de Masa Corporal , Dieta , Conducta Alimentaria , Obesidad/prevención & control , Caminata , Aumento de Peso , Pérdida de Peso , Adolescente , Adulto , Enfermedades Cardiovasculares/prevención & control , Correo Electrónico , Femenino , Humanos , Internet , Masculino , Proyectos de Investigación , Programas de Reducción de Peso/métodos , Adulto Joven
14.
JAMA ; 307(24): 2617-26, 2012 Jun 27.
Artículo en Inglés | MEDLINE | ID: mdl-22735431

RESUMEN

CONTEXT: Given the obesity epidemic, effective but resource-efficient weight loss treatments are needed. Stepped-treatment approaches customize interventions based on milestone completion and can be more effective while costing less to administer than conventional treatment approaches. OBJECTIVE: To determine whether a stepped-care weight loss intervention (STEP) compared with a standard behavioral weight loss intervention (SBWI) would result in greater weight loss. DESIGN, SETTING, AND PARTICIPANTS: A randomized clinical trial of 363 overweight and obese adults (body mass index: 25-<40; age: 18-55 years, 33% nonwhite, and 83% female) who were randomized to SBWI (n = 165) or STEP (n = 198) at 2 universities affiliated with academic medical centers in the United States (Step-Up Study). Participants were enrolled between May 2008 and February 2010 and data collection was completed by September 2011. INTERVENTIONS: All participants were placed on a low-calorie diet, prescribed increases in physical activity, and attended group counseling sessions ranging from weekly to monthly during an 18-month period. The SBWI group was assigned to a fixed program. Counseling frequency, type, and weight loss strategies could be modified every 3 months for the STEP group in response to observed weight loss as it related to weight loss goals. MAIN OUTCOME MEASURE: Mean change in weight over 18 months. Additional outcomes included resting heart rate and blood pressure, waist circumference, body composition, fitness, physical activity, dietary intake, and cost of the program. RESULTS: Of the 363 participants randomized, 260 (71.6%) provided a measure of mean change in weight over 18 months. The 18-month intervention resulted in weight decreasing from 93.1 kg (95% CI, 91.0 to 95.2 kg) to 85.6 kg (95% CI, 83.4 to 87.7 kg) (P < .001) in the SBWI group and from 92.7 kg (95% CI, 90.8 to 94.6 kg) to 86.4 kg (95% CI, 84.5 to 88.4 kg) in the STEP group (P < .001). The percentage change in weight from baseline to 18 months was -8.1% (95% CI, -9.4% to -6.9%) in the SBWI group (P < .001) compared with -6.9% (95% CI, -8.0% to -5.8%) in the STEP group (P < .001). Although the between-group difference in 18-month weight loss was not statistically different (-1.3 kg [95% CI, -2.8 to 0.2 kg]; P = .09), there was a significant group × time interaction effect (P = .03). The cost per participant was $1357 (95% CI, $1272 to $1442) for the SBWI group vs $785 (95% CI, $739 to $830) for the STEP group (P < .001). Both groups had significant and comparable improvements in resting heart rate, blood pressure level, and fitness. CONCLUSIONS: Among overweight and obese adults, the use of SBWI resulted in a greater mean weight loss than STEP over 18 months. Compared with SBWI, STEP resulted in clinically meaningful weight loss that cost less to implement. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00714168.


Asunto(s)
Obesidad/terapia , Sobrepeso/terapia , Pérdida de Peso , Adolescente , Adulto , Presión Sanguínea , Composición Corporal , Índice de Masa Corporal , Ahorro de Costo , Consejo , Dieta Reductora , Ejercicio Físico , Femenino , Frecuencia Cardíaca , Humanos , Masculino , Persona de Mediana Edad , Aptitud Física , Resultado del Tratamiento , Adulto Joven
15.
Front Psychol ; 13: 875085, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-35572267

RESUMEN

The human sensory system is continuously engaged in experiencing and interpreting every interaction with other living beings, objects, and the environment. The purpose of this article is to describe the impact limited opportunities for rich sensory experiences have on students with severe disabilities in two middle school classrooms situated in a public separate school in the southeastern USA. The study employed a postcritical ethnographic approach and grounded theory thematic analysis of fieldnotes gathered over a two-year period. Three major themes supported by the data are presented and discussed in depth. They are: (a) students are afforded limited sensory rich experiences, (b) everyday routines make students passive recipients to school, and (c) instructional approaches result in little interaction with extended periods of waiting. The implications of the findings for improved sensory experiences and possible future directions are described.

16.
Plant Physiol ; 154(2): 958-68, 2010 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-20724645

RESUMEN

The relationship between the transition to budding and flowering in Artemisia annua and the production of the antimalarial sesquiterpene, artemisinin (AN), the dynamics of artemisinic metabolite changes, AN-related transcriptional changes, and plant and trichome developmental changes were measured. Maximum production of AN occurs during full flower stage within floral tissues, but that changes in the leafy bracts and nonbolt leaves as the plant shifts from budding to full flower. Expression levels of early pathway genes known to be involved in isopentenyl diphosphate and farnesyl diphosphate biosynthesis leading to AN were not immediately positively correlated with either AN or its precursors. However, we found that the later AN pathway genes, amorpha-4,11-diene synthase (ADS) and the cytochrome P450, CYP71AV1 (CYP), were more highly correlated with AN's immediate precursor, dihydroartemisinic acid, within all leaf tissues tested. In addition, leaf trichome formation throughout the developmental phases of the plant also appears to be more complex than originally thought. Trichome changes correlated closely with the levels of AN but not its precursors. Differences were observed in trichome densities that are dependent both on developmental stage (vegetative, budding, and flowering) and on position (upper and lower leaf tissue). AN levels declined significantly as plants matured, as did ADS and CYP transcripts. Spraying leaves with AN or artemisinic acid inhibited CYP transcription; artemisinic acid also inhibited ADS transcription. These data allow us to present a novel model for the differential control of AN biosynthesis as it relates to developmental stage and trichome maturation and collapse.


Asunto(s)
Artemisia annua/genética , Artemisininas/metabolismo , Flores/crecimiento & desarrollo , Hojas de la Planta/crecimiento & desarrollo , Artemisia annua/crecimiento & desarrollo , Artemisia annua/metabolismo , Flores/genética , Flores/metabolismo , Regulación de la Expresión Génica de las Plantas , Hojas de la Planta/genética , Hojas de la Planta/metabolismo , ARN Mensajero/análisis , ARN de Planta/análisis , Transcripción Genética
17.
Res Dev Disabil ; 112: 103913, 2021 May.
Artículo en Inglés | MEDLINE | ID: mdl-33626486

RESUMEN

BACKGROUND: Providing emergent literacy intervention and assessing outcomes for children with low-incidence, complex disabilities with concomitant physical, cognitive, sensory, and communication impairments presents a significant challenge to researchers, educators, clinicians, and families alike. AIMS: This study aimed to leverage advancements in commercially available eyetracking technologies to measure visual attention to print before and after a parentmediated print referencing intervention with a child with a severe, low incidence, congenital disability. Print referencing means drawing attention to the print on the page while reading. METHODS AND PROCEDURES: The single case study investigated a mother-daughter dyad who completed the protocol using eye-gaze technology, digital children's books, and a computer configured with software for observing and recording interactions that were shipped to the family's home and set up by the mother with remote support from a researcher. OUTCOMES AND RESULTS: Results demonstrate that the eye-tracker successfully captured the participant's eye-gaze. Furthermore, mean-level shifts in frequency of fixations demonstrates changes in visual attention to print after the parent introduced the print referencing strategy during reading. CONCLUSIONS AND IMPLICATIONS: Commercially available eye-trackers and digital libraries were successfully used by the parent-child dyad to record visual attention. Furthermore, remote support from a trained researcher was sufficient to support the parent through set-up, calibration, intervention, and implementation.


Asunto(s)
Bibliotecas Digitales , Lectura , Femenino , Fijación Ocular , Humanos , Alfabetización , Padres , Proteínas Serina-Treonina Quinasas
18.
J Org Chem ; 75(21): 7129-40, 2010 Nov 05.
Artículo en Inglés | MEDLINE | ID: mdl-20925362

RESUMEN

The unusual base-induced ring-enlargement of halomethylenecyclobutanes to 1-halocyclopentenes was examined with unsymmetrical and (13)C-labeled substrates to study regio- and stereochemical characteristics. Migration of a ring carbon atom (single migration) or simultaneous migration of a ring carbon atom and the halide (double migration) gives the ring-enlarged products. (13)C-labeling experiments established that both rearrangements occur with retention of configuration at the migrating center. These systems are suggested as models for the Fritsch-Buttenberg-Wiechell (FBW) rearrangement.

19.
Augment Altern Commun ; 26(3): 177-90, 2010 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-20874080

RESUMEN

Research on reading in augmentative and alternative communication (AAC) is primarily provided for the English language, which has nontransparent orthographic depth and a complex syllable structure. While there is a great deal to learn about English reading in AAC, there is substantially more information regarding reading in AAC in English than in other languages. In this article we compare reading acquisition in English and German, drawing from the existing research regarding reading for children with complex communication needs and describing how that might apply to German and other European languages with orthography that is more consistent than English (e.g., Swedish, Spanish, Finnish; Aro & Wimmer, 2003). The goal is to support the development of cross-linguistic understandings in reading and AAC.


Asunto(s)
Equipos de Comunicación para Personas con Discapacidad , Trastornos de la Comunicación/rehabilitación , Lenguaje , Fonética , Lectura , Transferencia de Experiencia en Psicología , Escritura , Niño , Comprensión , Comparación Transcultural , Alemania , Humanos , Traducción , Estados Unidos , Aprendizaje Verbal , Vocabulario
20.
Lang Speech Hear Serv Sch ; 51(2): 494-503, 2020 04 07.
Artículo en Inglés | MEDLINE | ID: mdl-31951500

RESUMEN

Purpose Many children with severe intellectual and developmental disabilities are at a higher risk for hearing loss than their peers who are typically developing. Unfortunately, they do not consistently participate in routine school-based hearing screenings. The current study investigated the feasibility of increasing their participation using an otoacoustic emissions protocol and documented results relative to student educational profiles. Method A total of 43 students with significant cognitive disabilities enrolled at a public school exclusively serving this population participated in the study. All but 9, who were excluded because of known hearing loss, were screened by a licensed audiologist assisted by audiology doctoral students. The protocol included otoscopy, tympanometry, distortion product otoacoustic emissions (DPOAEs), and teacher surveys. Results DPOAE screening was attempted on 33 students without previously diagnosed hearing loss and successfully completed for 26 (78.8%). Two students (4.6%) with absent otoacoustic emissions and normal tympanograms were referred for further assessment due to concerns about possible sensorineural hearing loss in one or both ears, and 10 (23.3%) had abnormal tympanograms in one or both ears. Conclusions Considering the high risk of sensorineural hearing loss for children with significant disabilities, it is important for them to be included in school hearing screenings. The results of this study demonstrate the feasibility of using DPOAEs for school-based hearing screenings with this population with an interprofessional team of licensed audiologists, educators, and speech-language pathologists. The results further suggest that students with significant disabilities and hearing loss may be unidentified and underserved. Given the complex needs of this population, an interprofessional practice model for hearing screenings and intervention services is recommended.


Asunto(s)
Pruebas de Impedancia Acústica , Trastornos del Conocimiento/diagnóstico , Pérdida Auditiva/diagnóstico , Emisiones Otoacústicas Espontáneas , Otoscopía , Adolescente , Adulto , Niño , Preescolar , Cognición , Trastornos del Conocimiento/complicaciones , Femenino , Pérdida Auditiva/complicaciones , Humanos , Masculino , Tamizaje Masivo/métodos , Proyectos Piloto , Servicios de Salud Escolar/organización & administración , Instituciones Académicas , Estudiantes , Adulto Joven
SELECCIÓN DE REFERENCIAS
Detalles de la búsqueda