[The effect of histamine on the tonus of isolated coronary arteries with intact and damaged endothelium]. / Vliianie gistamina na tonus izolirovannykh koronarnykh arterii s intaktnym i povrezhdennym éndoteliem.

In isolated rings of the pig coronary arteries mechanical damage of endothelium led to a considerable reduction of coronary spastic responses to histamine due to the H1-receptors damage after the denudation of endothelium. The tachyphylaxis to histamine was eliminated after de-endothelialization. The drugs blocking H1-receptors such as dimedrol, were effective for preventing the histamine coronary vasospasm.

[The mechanisms of the interaction of sex hormones with serum albumin and gamma-globulins studied by the methods of equilibrium dialysis and fluorescence quenching]. / Mekhanizmy vzaimodeistviia polovykh gormonov s syvorotochnym al'buminom i gamma-globulinami metodami ravnovesnogo dializa i tusheniia fliuorestsentsii.

The molecular mechanisms of sex hormones (testosterone, progesterone, 17 beta-estradiol) binding with human serum albumin and gamma-globulins were studied. According to the data of equilibrium dialysis, all the sex hormones under study bind with the blood plasma proteins, mainly with the serum albumin. In interaction of the sex hormones with serum albumin and gamma globulins, conformation changes of the proteins occur increasing their molecular affinity.

[Effect of sex hormones on lipid peroxidation in the rat aorta]. / Perekisnoe okislenie lipidov v aorte krysy pri deistvii polovykh gormonov.

The effect of sex hormones on lipid peroxidation (LPO) in the wall of the aorta of male rats was studied in vivo and in vitro. Female sex hormones (17 beta-estradiol and progesterone) inhibited LPO in the aorta: 17 beta-estradiol caused a maximum antioxidant effect at the beginning of its action, progester one during prolonged action. Testosterone had a marked prooxidant effect, activating lipid LPO in the aorta both in vivo and in vitro whatever its concentration and duration of incubation.

[The protective effect of 17 beta-estradiol in experimental myocardial infarct]. / Zashchitnyi éffekt 17 beta-éstradiola pri éksperimental'nom infarkte miokarda.

The effect of 17 beta-estradiol on the regions of ischemia and necrosis in experimental myocardial infarction was studied in the experiments on rats. The ability of the hormone to decrease the damaged area due to anti-ischemic and antinecrotic effects is found.

[An experimental study of the cardiovascular activity of nistranol]. / Eksperimental'noe issledovanie serdechno-sosudistoi aktivnosti nistranola.

In concentrations of > or = 10(-5) mol/liter nistranol (11 beta-nitroxy-9 alpha-hydroxy-ethynylestradiol-diacetate) demonstrated cardiac and vascular activity in vitro. It caused concentration-dependent and reversible increase of the contractile parameters of an isolated atrial appendage of rats. A three-phase effect of nistranol on a isolated rat thoracic aorta was encountered: vasodilatation-vasoconstriction-vasodilatation. Anti-ischemic and antinecrotic effects of nistranol were noted in experimental myocardial infarction.

[The role of peripheral cholinergic and adrenergic receptor systems in the action of histamine on the isolated coronary arteries]. / Ro'l perifericheskoi kholinergicheskoi i adrenergicheskoi retseptsii v deistvii gistamina na izolirovannye koronarnye arterii.

The action of peripheral cholinergic and adrenergic receptor systems on the histamine coronary vasospastic effects are investigated in the experiments on the isolated ring-shaped strips of coronary arteries of pigs with the aid of specific agonists and antagonists. It has been demonstrated that neuromediator systems play a significant role in the regulation of contractile activity of the coronary spasm pathogenesis. When medicines are prescribed to patients with ischemic heart disease it is necessary to take into account the character of the preparations interaction which affect the peripheral neuromediator processes such as histaminergic, cholinergic, adrenergic and others.

[Choice of optimal gestagen for combined hormonal replacement therapy in the peri- and postmenopause].

Menopause, being the end of the reproductive period of a woman's life, is characterized by changes in the endocrine balance in the body, significantly affecting health, quality of life and general life prognosis. These changes can be more significant and even take on a fatal character with "forced", artificial (surgical) menopause.