1.
Adv Healthc Mater
; 6(1)2017 Jan.
Artículo
en Inglés
| MEDLINE
| ID: mdl-28075069
RESUMEN
Ebola DNA vaccine is incorporated into PLGA-PLL/γPGA nanoparticles and administered to skin using a microneedle (MN) patch. The nanoparticle delivery system increases vaccine thermostability and immunogenicity compared to free vaccine. Vaccination by MN patch produces stronger immune responses than intramuscular administration.