Analysis aqueous humor lipid profile of neovascular glaucoma secondary to diabetic retinopathy and lipidomic alteration response to anti-VEGF treatment.

The objective of this study was to examine the lipid spectrum of aqueous humor (AH) in patients with neovascular glaucoma (NVG) secondary to proliferative diabetic retinopathy and to investigate the lipid alteration response to anti-vascular endothelial growth factor (anti-VEGF) treatment. Lipidomic analysis using ultra-high performance liquid chromatography-tandem mass spectrometry was conducted to compare the lipid profiles of the AH in NVG patients with those of a control group. Lipid changes in the AH of NVG patients before and after intravitreal conbercept injections were also evaluated. The identification of lipids showing differential expression was accomplished through both multivariate and univariate analyses. This study included 13 NVG patients and 20 control subjects. Based on LipidSearch software, 639 lipid species across 33 lipid classes were detected in the participants' AH. The combination of univariate and multivariate statistical analyses yielded 53 differentially expressed lipids (VIP >1 and P < 0.05). In addition, 9 lipids were found to be differentially expressed before and after the intravitreal conbercept injections in the NVG patients. Significant alterations in the metabolic pathways of glycerophospholipid and glycerolipid exhibited notable changes. Our results highlighted the lipid changes in patients' AH in relation to the progression of NVG, and indicated that the modified lipids could potentially be utilized as therapeutic targets for NVG.

[Current views on pathogenesis and treatment of neovascular glaucoma]. / Sovremennye vzglyady na patogenez i lechenie neovaskulyarnoi glaukomy.

Neovascular glaucoma is a type of secondary glaucoma characterized by the most severe course, and ranking second among the causes of irreversible blindness. This review summarizes the results of numerous studies devoted to the search for prevention measures and the most effective treatment strategy. The main ways of preventing the development of neovascular glaucoma are timely diagnosis and elimination of ischemic processes in the retina, combined with adequate control of intraocular pressure and treatment of the underlying disease.

Secondary Neovascular Glaucoma in the Course of Diabetes in a Kidney Transplant Recipient: Case Report and Review of the Literature.

BACKGROUND: The increase in intraocular pressure during hemodialysis challenges nephrologists and ophthalmologists. It most often affects patients with previously diagnosed glaucoma and is particularly dangerous in the setting of diabetic retinopathy. Hypoperfusion and hypoxia of the retina may occur, leading to pathologic neovascularization in the retina and the anterior chamber angle. Changes in the filtration angle block the outflow of aqueous humor and cause secondary glaucoma. A special type of glaucoma is neovascular glaucoma, developing among others in patients with diabetic retinopathy. This study describes a patient with secondary neovascular glaucoma in whom a significant increase in intraocular pressure was observed during hemodialysis, not responding to the applied topical treatment. METHODS: The patient experienced severe pain, and her cornea was constantly injured by paracentesis. Ultimately, secondary glaucoma led to a significant decrease in vision in both eyes. The patient was enrolled on a transplant waiting list and transplanted with priority. RESULTS: The patient experienced some urologic and infectious complications, although 7 months after transplantation, her creatinine concentration was 1.2 mg/dL, and the ocular disease was stabilized. The intraocular pressure decreased, but there were still values above the norm, which required periodic injections of anti-vascular endothelial growth factor into the vitreous chamber and 5-fluorouracil injections under the conjunctiva. CONCLUSIONS: Patients with diabetes and secondary neovascular glaucoma on dialysis constitute an extremely difficult therapeutic problem and require the involvement of several specialists. Successful kidney transplantation, besides ameliorating general clinical conditions, may increase the chance of successful ophthalmologic treatment.

The effect of the intercellular adhesion molecule-1 and glycated haemoglobin on the management of diabetic neovascular glaucoma.

Introduction: The study hypothesizes that some patients with diabetic neovascular glaucoma (NVG) do not fully respond to transscleral (TSC) cyclophotocoagulation (CPC) due to significant inflammation and insufficient glucose control. Objective: The study aimed to determine the effect of baseline blood levels of intercellular adhesion molecule-1 (ICAM-1) and glycated haemoglobin (HbA1c) on the management of patients with diabetic NVG by TSC CPC. Methods: This open prospective study included 70 diabetic patients (75 eyes; aged Ме 63.0 years) with painful NVG and 20 healthy individuals (aged Ме 61.5 years) as an immunological control. All patients underwent TSC СPC with a diode laser. Baseline HbA1c levels and ICAM-1 expression in blood samples were determined. Follow-up was 12 months. Results: One month after TSC CPC, IOP decreased by 28% compared to baseline. The effectiveness of laser treatment after 12 months of follow-up was 63% with IOP decrease by 46%. In patients with NVG, the initial level of ICAM-1 was 2.5 times higher than in the control group. Patients who did not fully respond to the first TSC CPC (30 eyes) and required additional laser procedure, had high initial HbA1c (9.5%) and high expression values of the ICAM-1 (609.0 cells/µL). Conclusions: Repeated procedures of TSC CPC at high IOP in diabetic patients with NVG are associated with high initial values of expression of ICAM-1 in peripheral blood and high HbA1c. The strategy of management of patients with diabetic NVG should be aimed at intensive glucose control and local anti-inflammatory treatment. Abbreviations: PDR = proliferative diabetic retinopathy, DR = diabetic retinopathy, NVG = neovascular glaucoma, TSC CPC = transscleral cyclophotocoagulation, ICAM-1 = intercellular adhesion molecule-1, HbA1c = glycated haemoglobin, IOP = intraocular pressure.

Unusual clinical features and histopathological findings in a case of Pseudo-endophthalmitis in neovascular glaucoma.

Objective: This case report aimed to describe the unusual clinical presentation and histopathological features of post-injection endophthalmitis. Methods: A 56-year-old male phakic patient with diabetic retinopathy received an intravitreal injection (Bevacizumab as per the patient) for neovascular glaucoma elsewhere and presented to our center one day after the dose with hypopyon. The eye was relatively white without pain or lid oedema. The patient was treated as a case of post-injection endophthalmitis with two doses of intravitreal antibiotics 48 hours apart. During the follow-up, he developed a Covid infection. After one week, when the media cleared, white exudates were seen in the vitreous cavity with a relatively healthy retina. He was taken up for pars plana vitrectomy and vitreous biopsy for histopathological study. Results: The microscopic examination of vitreous aspirate revealed crystalline deposits without any microorganisms. Two control slides, one with a mixture of intravitreal antibiotics, which were previously injected, and the other with fresh Triamcinolone were also examined. Although the findings of the drug mixture did not match the vitreous aspirate, they matched with triamcinolone, which established it as a case of pseudo endophthalmitis due to triamcinolone injected elsewhere. Discussion: Initially, it seemed like a straightforward case of post-injection endophthalmitis, but a further examination of the vitreous aspirate showed that it was pseudoendophthalmitis due to an intravitreal triamcinolone injection. Despite the patient being phakic, neovascularization or elevated intraocular pressure may have led to the disruption of the blood-ocular barrier and the migration of Triamcinolone into the anterior chamber. Conclusion: The case's uniqueness lies in being the first reported case of pseudo endophthalmitis in a phakic patient with an intact lens iris diaphragm. The case also highlighted the judicious use of available resources and out-of-the-box thinking to reach a diagnosis that may not always be obvious. Abbreviations: TA = Triamcinolone acetonide, AC = Anterior chamber, IVB = Intravitreal Bevacizumab, PL = Perception of light.

Fibrilación auricular no valvular y obstrucción venosa retiniana: la Cohorte Valdecilla / Nonvalvular atrial fibrillation and retinal vein occlusion: The Valdecilla Cohort

Introduction and objectives Retinal vein occlusion (RVO) and nonvalvular atrial fibrillation (NVAF) are associated with vascular risk factors (VRF) and aging. The aim of this study is to analyze differences in the prevalence of VRF, vascular events, glaucoma, and anticoagulant treatment in patients with NVAF and RVO compared to a control group of the general population from the same geographic area. Methods This is a prospective, single-center, case-control study. All patients diagnosed with RVO from December 2008 to March 2020 as well as a control group were included. Clinical, laboratory, electrocardiographic, and carotid ultrasound variables were analyzed. Results A total of 386 patients with RVO and 343 controls were studied. Patients with RVO and NVAF were older and more of them had hypertension, a history of vascular events, and carotid atheromatosis than subjects with RVO without NVAF. In patients with NVAF who were on anticoagulants, those who had RVO differed from the controls with NVAF in that they had a higher prevalence of glaucoma (32 vs. 5.3%; p<0.034), with no significant differences regarding age, VRF, vascular events, or type of anticoagulant therapy (acenocumarol or direct-acting oral anticoagulants). Conclusions Patients with RVO and NVAF were older and had a higher prevalence of hypertension and carotid atheromatosis than subjects with RVO without NVAF. Patients with NVAF and RVO had higher prevalence of glaucoma than subjects with NVAF without RVO. In patients with NVAF, it is recommended to optimized VRF treatment and glaucoma control to prevent the development of RVO (AU)

Introducción y objetivos La obstrucción venosa retiniana (OVR) y la fibrilación auricular no valvular (FANV) se relacionan con los factores de riesgo vascular (FRV) y con el envejecimiento. Este trabajo tiene por objetivo analizar las diferencias en la prevalencia de los FRV, de los eventos vasculares, del glaucoma y del tratamiento anticoagulante en los pacientes con FANV y OVR comparada con un grupo control de la población general de la misma área geográfica. Métodos Estudio prospectivo unicéntrico de casos y controles. Se incluyeron todos los pacientes diagnosticados de OVR desde diciembre de 2008 hasta marzo de 2020, y un grupo control. Se analizaron variables clínicas, de laboratorio, electrocardiográficas y de ultrasonidos de carótida. Resultados Se estudiaron 386 pacientes con OVR y 343 controles. Los pacientes con FANV y OVR eran de mayor edad, tenían más hipertensión, antecedente de eventos vasculares y ateromatosis carotídea que los sujetos con OVR sin FANV. En los pacientes con FANV anticoagulados, aquellos que tenían OVR, diferían de los controles con FANV en una mayor prevalencia de glaucoma (32 vs. 5,3%; p<0,034), sin hallarse diferencias significativas respecto a la edad, los FRV, los eventos vasculares o la terapia anticoagulante pautada (acenocumarol o anticoagulantes de acción directa). Conclusiones Los pacientes con OVR y FANV tienen mayor edad y mayor prevalencia de hipertensión arterial, y ateromatosis carotídea que los que no tienen FANV. Aquellos con FANV y OVR difieren de los que no tienen OVR en la mayor incidencia de glaucoma. En los pacientes con FANV sugerimos optimizar el tratamiento de los FRV y el control del glaucoma para prevenir el desarrollo de la OVR (AU)

Glaucoma neovascular causado por metástasis de carcinoma microcítico de pulmón. Presentación de un caso / Neovascular glaucoma caused by small-cell lung cancer iris metastasis: A case presentation

El carcinoma microcítico de pulmón puede afectar al ojo directamente mediante proliferación metastásica o indirectamente a través de síndromes paraneoplásicos. La coroides es el lugar más afectado entre las metástasis uveales; no obstante, el iris puede estar envuelto en una proporción pequeña de casos (<10%). Visión borrosa, dolor, hiperemia, fotofobia, glaucoma, hipema o defectos en el campo visual pueden originarse por la afectación metastásica. La mediana de supervivencia en pacientes con metástasis iridianas es de 4 meses. El glaucoma secundario que se origina puede ser manejado con tratamiento tópico y oral, ciclo fotoablación transescleral, trabeculoplastia con láser, anti-VEGF, MIGS, cirugía filtrante o enucleación. Se presenta un caso único que desarrolló un cáncer microcítico de pulmón primario con metástasis iridianas. Las metástasis provocaron un cierre angular, refractario al tratamiento tópico. Se realizó radioterapia local para conseguir una respuesta local (AU)

Small-cell lung cancer may directly affect the eye by metastatic proliferation or indirectly by paraneoplastic syndromes. The choroid is the most common site for uveal metastasis (90%); however, the iris can be involved in a smaller proportion of cases (incidence <10%). Blurred vision, pain, redness, photophobia, glaucoma, hyphema and visual field defects can arise from this metastatic involvement. The median survival time for patients with iris metastasis is reported to be 4 months. Secondary glaucoma can be managed with topical and oral treatment, transscleral cyclophotocoagulation, laser trabeculoplasty, anti-VEGF, minimally invasive glaucoma surgery (MIGS), filtering surgery, shunting surgery or enucleation. A case of primary small-cell lung cancer with iris metastasis is presented. The metastases produced an angle-closure glaucoma, which was refractory to topical treatment. Local radiotherapy was administered, obtaining a good local response (AU)

Glaucome néovasculaire: étiologies et difficultés liées à sa prise en charge à Brazzaville

INTRODUCTION: Le glaucome neovasculaire (GNV) est lie a une neovascularisation de l'angle iridocorneen secondaire a une hypoxie prolongee de la retine. Dans les pays occidentaux; son traitement est bien codifie et le pronostic est bien meilleur qu'a Brazzaville ou le GNV se termine souvent par une enucleation suite a une phtise hyperalgique ou a un eclatement spontane de l'oil. OBJECTIF: enumerer les principales etiologies du GNV et discuter des difficultes liees a sa prise en charge a Brazzaville. MATeRIELS ET MeTHODES: etude transversale; multicentrique (CHU/Brazzaville; Clinique Medicale de Brazzaville); realisee sur une periode de 7 ans sur la base de dossiers de patients vus pour un GNV. Le GNV etait defini par l'association d'une rubeose irienne et d'un tonus oculaire superieure a 21 mm Hg. Les parametres suivant etaient analyses: motifs de consultation; presentations cliniques; etiologies et traitements.ReSULTATS : 25 dossiers ont ete retenus (correspondant a 30 yeux souffrant de GNV). La douleur oculaire etait le principal motif de consultation (92%; 23/25 patients). La cornee etait opaque avec gonoscopie et fond d'oeil impossibles dans 83;33% des cas (25/30 yeux). Les etiologies etaient: diabete sucre (88%; 22/25 patients); occlusion de la veine centrale de la retine (12%; 3/25 patients). Perdus de vue 7/25 patients correspondant a 7/30 yeux. Le traitement consistait en enucleation (69;56%; 16/23 yeux); photocoagulation retinienne (21;74%; 5/23 yeux); et injection retrobulbaire de Chlorpromazine (8;70%; 2/23 yeux). CONCLUSION: Le diabete sucre est la principale etiologie du GNV a Brazzaville. Le manque de moyens techniques et les consultations tardives n'offrent que peu d'alternative therapeutique a l'enucleation qui reste largement malheureusement utilisee

Radiation-Induced Neovascular Glaucoma: Dose and Volume Issues

No abstract available.

Opacification of the Optic of an Akreos Adapt Intraocular Lens

A 60-year-old diabetic patient transferred to our retina clinic for a regular follow-up for diabetic retinopathy. He had uneventful cataract surgery at the time of pars plana vitrectomy in the right eye due to diabetic retinopathy at a private ophthalmologic hospital. Six months after the surgery, neovascular glaucoma with hyphema developed in the right eye and an Ahmed valve was implanted at our hospital. Ten months after cataract surgery, we found opacification of the intraocular lens (IOL) which was causing significant visual disturbance. At the time, the best corrected visual acuity (BCVA) in the right eye was hand motion. The IOL was explanted 45 months after the operation. Five months after explantation, the BCVA was 0.06. Unfortunately, pathologic analysis was not performed. Patient-related factors such as an anterior chamber reaction caused by hyphema might have been responsible for the opacification. To our knowledge, there are no previous reports of opacification of the Akreos Adapt IOL.

Síndrome ocular isquêmica associada a glaucoma neovascular: relato de um caso / Ocular ischaemic syndrome associated with neovascular glaucoma: a case report

Os autores apresentam um caso de glaucoma neovascular secundário à síndrome ocular isquêmica como manifestaçäo inicial de doença oclusiva de artérias carótidas. O exame de Doppler colorido das carótidas e órbitas mostrava presença de todos os fatores associados a um maior risco de desenvolver a síndrome: estenose carotídea grave bilateral, alto grau de estenose da artéria carótida interna e fluxo reverso na artéria oftálmica. Os autores discutem o fato do glaucoma neovascular ter sido controlado com apenas uma medicaçäo tópica.

Diabetes y glaucoma: diagnóstico y algoritmo terapéutico / Diabetes and glaucoma: diagnostic approach and therapeutic algorithm

El paciente diabético puede presentar glaucoma crónico, de forma indistinguible al paciente sin diabetes. El manejo del glaucoma en el paciente diabético no presenta particularidades, excepto que hay que mostrar especial cuidado con ciertos efectos adversos de la medicación. Sin embargo, algunos pacientes diabéticos pueden presentar un glaucoma neovascular cuya etiopatogenia, tratamiento y pronóstico sí difieren en gran medida de los habituales en el glaucoma crónico. En este trabajo presentamos una revisión del diagnóstico y el tratamiento de estas dos situaciones: el glaucoma neovascular y el glaucoma crónico en el paciente diabético

Diabetic patients might show chronic glaucoma, unnoticeable to the patient not affected by diabetes. The treatment of glaucoma does not present in this case any particular features, except for the special care of possible collateral effects as a result of medication. However, some diabetic patients might show neovascular glaucoma whose ethiopathogeny, treatment and prognosis differ to a great extent from those normally found in chronic glaucoma. We present in this paper a review of the diagnosis and treatment of these two situations: neovascular glaucoma and chronic glaucoma indiabetic patients

Glaucoma neovascular secundario o capsulotomía posterior con láser de Yag-Neodimium en diabéticos sin retinopatía / Neovascular glaucoma after Nd-YAG posterior capsulotomy in diabetic subjects without retinopathy

Se reportan dos casos de neovascularización iridiana y glaucoma neovascular diagnosticados en dos sujetos diabéticos sin signos de retinopatía diabética observada por clínica, angiografía retiniana o ecografía y con diagnóstico de catarata, en quienes se realiza capsulotomía posterior con láser de Yag-Neodimium después de la extracción extracapsular de catarata y colocación de lente intraocular no complicada. Estos casos concuerdan con las hipótesis sobre la función de la cápsula posterior como barrera a factores vasoproliferativos difusibles desde el vítreo o retina hacia la región ocular anterior. La utilización del láser de Yag-Neodimium en el tratamiento de cápsulas posteriores opacificadas tienen excelentes resultados visuales, pero los efectos adversos deben ser considerados antes de efectuar este tratamiento en sujetos diabéticos o con retinopatías hipóxicas. Después de la capsulotomía y angiografía retiniana y en caso de encontrar datos de isquemia y neovascularización se debe considerar la panretinofotocoagulación como tratamiento preventivo del glaucoma neovascular

Glaucoma neovascular por retinopatia diabética proliferativa: relato de caso clínico com o tratamento pela cirurgia antiproliferativa via endoscopia / Neovascular glaucoma after proliferative diabetic retinopathy: clinical case treated with the antiproliferative surgery and endoscopic cyclo-photocoagulation

Objetivos: Os autores apresentam o caso clínico de um paciente portador de glaucoma neovascular decorrente de retinopatia diabética proliferativa em seu único olho com visão e que foi tratado cirurgicamente com uma combinaçào de procedimentos conhecida como "cirurgia antiproliferativa"a qual consta de lensectomia sem implantação de lente intra-ocular, vitrectomia via pars plana, endopantocoagulação retiniana com diodo laser e endofotocoagulação direta dos processos ciliares em 270º com diodo laser aplicado através do endoscópio via pars plana. Descrição do caso: paciente com 63 anos de idade, portador de retinopatia diabética proliferativa avançada bilateral sem tratamentos prévios por fotocoagulação com laser, com visão apenas de percepção luminosa no OD e amaurose no OE, desenvolveu hemorragia intravítrea total e glaucoma neovascular após formação de "rubeosis iridis" em seu olho único com visão e catarata secundária. Não se conseguiu controle da pressão intra-ocular com tratamento clínico e o mesmo foi submetido à cirurgia de lensectomia sem implantação de lente intra-ocular, vitrectomia via pars plana, endopanfotocoagulação retiniana com diodo laser e endofotocoagulação direta dos processos ciliares em 270º com diodo laser aplicado através do endoscópio via pars plana com os objetivos de melhorar a transparência dos meios, pantofotocoagular a retinopatia diabética proliferativa diminuindo a isquemia periférica e melhorar as condições do glaucoma neovascular tentando-se preservar a visão nas melhores condições possíveis, pois a tendência natural seria a amaurose do olho único por pressões intra-oculares permanentemente acima de 40mmHg apesar do tratamento clínico. Instituição: Curso de Especialização em Oftalmologia do Hospital Banco de Olhos de Porto Alegre. Comentários: Após a cirurgia o paciente melhorou a visão de percepção luminosa para 20/40 com a correção óptica. Ocorreu redução e controle da pressão intra-ocular no pós-operatório com o uso apenas de colírio betabloqueador apesar de não ocorrer regressão ou progressão da "rubeosis iridis"pré-existente. esta situação permaneceu mais ou menos inalterada por quase 10 meses após o procedimento com o paciente mantendo acuidade visual de 20/40. O mesmo desenvolveu, após este período, nova hemorragia na cavidade vítrea possivelmente decorrente de piora de sua condição clínica geral em função do diabetes e veio a falecer pouco tempo após.