Detalhe da pesquisa
1.
Overcoming resistance to checkpoint blockade therapy by targeting PI3Kγ in myeloid cells.
Nature
; 539(7629): 443-447, 2016 11 17.
Artigo
Inglês
| MEDLINE | ID: mdl-27828943
2.
Inhibition of de novo lipogenesis targets androgen receptor signaling in castration-resistant prostate cancer.
Proc Natl Acad Sci U S A
; 116(2): 631-640, 2019 01 08.
Artigo
Inglês
| MEDLINE | ID: mdl-30578319
3.
CDKI-73: an orally bioavailable and highly efficacious CDK9 inhibitor against acute myeloid leukemia.
Invest New Drugs
; 37(4): 625-635, 2019 08.
Artigo
Inglês
| MEDLINE | ID: mdl-30194564
4.
Ex uno plures: clonal reinforcement drives evolution of a simple microbial community.
PLoS Genet
; 10(6): e1004430, 2014 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-24968217
5.
A Central Bioactive Region of LTBP-2 Stimulates the Expression of TGF-ß1 in Fibroblasts via Akt and p38 Signalling Pathways.
Int J Mol Sci
; 18(10)2017 Oct 09.
Artigo
Inglês
| MEDLINE | ID: mdl-28991210
6.
Experimental microbial evolution: history and conceptual underpinnings.
Genomics
; 104(6 Pt A): 393-8, 2014 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-25315137
7.
The pre-clinical absorption, distribution, metabolism and excretion properties of IPI-926, an orally bioavailable antagonist of the hedgehog signal transduction pathway.
Xenobiotica
; 43(10): 875-85, 2013 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-23527529
8.
Candidate genes affecting stomatal density in rice (Oryza sativa L.) identified by genome-wide association.
Plant Sci
; 330: 111624, 2023 May.
Artigo
Inglês
| MEDLINE | ID: mdl-36737006
9.
The development of proteasome inhibitors as anticancer drugs.
Cancer Cell
; 5(5): 417-21, 2004 May.
Artigo
Inglês
| MEDLINE | ID: mdl-15144949
10.
Hsp90 (heat shock protein 90) inhibitor occupancy is a direct determinant of client protein degradation and tumor growth arrest in vivo.
J Biol Chem
; 285(51): 39835-43, 2010 Dec 17.
Artigo
Inglês
| MEDLINE | ID: mdl-20940293
11.
Model for growth hormone receptor activation based on subunit rotation within a receptor dimer.
Nat Struct Mol Biol
; 12(9): 814-21, 2005 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-16116438
12.
Regiospecific and stereoselective syntheses of (+/-) morphine, codeine, and thebaine via a highly stereocontrolled intramolecular 4 + 2 cycloaddition leading to a phenanthrofuran system.
J Am Chem Soc
; 131(32): 11402-6, 2009 Aug 19.
Artigo
Inglês
| MEDLINE | ID: mdl-19624126
13.
Targeting CDK9 for treatment of colorectal cancer.
Mol Oncol
; 13(10): 2178-2193, 2019 10.
Artigo
Inglês
| MEDLINE | ID: mdl-31398271
14.
Structural studies of the Alzheimer's amyloid precursor protein copper-binding domain reveal how it binds copper ions.
J Mol Biol
; 367(1): 148-61, 2007 Mar 16.
Artigo
Inglês
| MEDLINE | ID: mdl-17239395
15.
The proteasome: a suitable antineoplastic target.
Nat Rev Cancer
; 4(5): 349-60, 2004 May.
Artigo
Inglês
| MEDLINE | ID: mdl-15122206
16.
A phase 2 study of bortezomib in relapsed, refractory myeloma.
N Engl J Med
; 348(26): 2609-17, 2003 Jun 26.
Artigo
Inglês
| MEDLINE | ID: mdl-12826635
17.
Structure of Alzheimer's disease amyloid precursor protein copper-binding domain at atomic resolution.
Acta Crystallogr Sect F Struct Biol Cryst Commun
; 63(Pt 10): 819-24, 2007 Oct 01.
Artigo
Inglês
| MEDLINE | ID: mdl-17909280
18.
Expression, purification, crystallization and preliminary X-ray diffraction analysis of chloride intracellular channel 2 (CLIC2).
Acta Crystallogr Sect F Struct Biol Cryst Commun
; 63(Pt 11): 961-3, 2007 Nov 01.
Artigo
Inglês
| MEDLINE | ID: mdl-18007051
19.
Calorimetric and structural studies of the nitric oxide carrier S-nitrosoglutathione bound to human glutathione transferase P1-1.
Protein Sci
; 15(5): 1093-105, 2006 May.
Artigo
Inglês
| MEDLINE | ID: mdl-16597834
20.
Phase II clinical experience with the novel proteasome inhibitor bortezomib in patients with indolent non-Hodgkin's lymphoma and mantle cell lymphoma.
J Clin Oncol
; 23(4): 676-84, 2005 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-15613699