Female Multiple Orgasm: An Exploratory Internet-Based Survey.

Women's multiorgasmic capacity has long been mentioned in the human sexuality literature. However, due in part to the conceptual vagueness surrounding this phenomenon, few empirical studies have focused on this topic, and our scientific knowledge is currently limited. This exploratory research is mainly aimed at providing a much-needed assessment of the profiles of women reporting multiorgasmic experiences. For this study, 419 sexually diverse women ages 18 through 69 who identified as multiorgasmic completed an online survey assessing variables pertaining to sociodemographic background, context and characteristics of a recent/typical multiorgasmic experience, relationships between multiple orgasm and sexual/nonsexual aspects of life, and sexual and orgasmic history. Data reduction analyses using principal component analysis pointed out that 15 variables of interest were distributed across six components, accounting for a large proportion of the sample's variance. A k-means cluster analysis further revealed that four distinct groups of women could be parsed out. These four groups could be differentiated by three sets of variables-sexual motivation, sexual history, and multiple orgasm characteristics-suggesting that female multiple orgasm is not a unitary phenomenon. This research provides to date the most comprehensive picture of female multiple orgasm and helps refine our conceptual understanding.

CPAP Treatment Adherence in Women with Obstructive Sleep Apnea.

Untreated obstructive sleep apnea (OSA) has numerous negative health-related consequences. Continuous positive airway pressure (CPAP) is generally considered the treatment of choice for OSA, but rates of nonadherence are high. It is believed that OSA is more prevalent among men; therefore understanding how OSA presents among women is limited and treatment adherence has received little research attention. For this study, 29 women were recruited from primary care offices. They completed a questionnaire battery and underwent a night of nocturnal polysomnography (PSG) followed by a visit with a sleep specialist. Women diagnosed with OSA were prescribed CPAP; 2 years later CPAP adherence was evaluated. Results show that approximately half the sample was adherent. There were no significant differences between adherent and nonadherent women on OSA severity; however CPAP adherent women had worse nocturnal and daytime functioning scores at the time of diagnosis. Moreover, when the seven nocturnal and daytime variables were used as predictors in a discriminant analysis, they could predict 87% of adherent and 93% of the nonadherent women. The single most important predictor was nonrefreshing sleep. We discuss the implications of the findings for identifying women in primary care with potential OSA and offer suggestions for enhancing treatment adherence.

Prevalence and characteristics of chronic sensory problems in burn patients.

Problems of pain and paresthesia in the healed wounds of burn patients are an understudied and poorly documented phenomenon. This descriptive study was designed to examine the prevalence and characteristics of these chronic sensory problems 1 year or more postburn. Four hundred and thirty patients were sent questionnaires which assessed the frequency and intensity of the problems, influencing factors and impact on patients' lives. These problems were assessed by rating scales (visual analogue and categorical scales) and the McGill Pain Questionnaire (MPQ). The response rate was 67%. Over one-third of the participants (36.4%) complained of pain while the prevalence of paresthetic sensations was 71.2%. More than half of the symptomatic patients experienced sensory problems every week sufficient to interfere with daily living. No relationships were found between these sensory problems and the patients' age or sex, burn etiology, or length of time elapsed since injury. Burn severity was related to the frequency of the problems. Discussion emphasizes the need for adequate treatment of these problems and suggests further research issues.

Nonspecific vaginitis. Diagnostic criteria and microbial and epidemiologic associations.

Numerous previous studies of nonspecific vaginitis have yielded contradictory results regarding its cause and clinical manifestations, due to a lack of uniform case definition and laboratory methods. We studied 397 consecutive unselected female university students and applied sets of well defined criteria to distinguish nonspecific vaginitis from other forms of vaginitis and from normal findings. Using such criteria, we diagnosed nonspecific vaginitis in up to 25 percent of our study population; asymptomatic disease was recognized in more than 50 percent of those with nonspecific vaginitis. A clinical diagnosis of nonspecific vaginitis, based on simple office procedures, was correlated with both the presence and the concentration of Gardnerella vaginalis (Hemophilus vaginalis) in vaginal discharge, and with characteristic biochemical findings in vaginal discharge. Nonspecific vaginitis was also correlated with a history of sexual activity, a history of previous trichomoniasis, current use of nonbarrier contraceptive methods, and, particularly, use of an intrauterine device. G. vaginalis was isolated from 51.3 percent of the total population using a highly selective medium that detected the organism in lower concentration in vaginal discharge than did previously used media. Practical diagnostic criteria for standard clinical use are proposed. Application of such criteria should assist in clinical management of nonspecific vaginitis and in further study of the microbiologic and biochemical correlates and the pathogenesis of this mild but quite prevalent disease.

Visual-spatial localization by patients with frontal-lobe lesions invading or sparing area 46.

Monkeys with unilateral principal sulcus (PS) lesions show a contralateral deficit in localizing remembered targets, especially as the recall interval is lengthened. We tested 20 patients with unilateral frontal-lobe excisions that invaded (FI) or spared (FS) area 46 (putative homologue of PS) and 32 normal controls (NC) on a task where subjects had to indicate the location of a light dot either immediately, or after 30 s, with or without interference. The FI group was worse than the NC group following both delay conditions. NC and FS groups differed only after interference. We concluded that area 46 is involved in recalling the location of visual targets, but unlike the monkey, the deficit is not restricted to a particular part of the visual field.

A visual analogue thermometer for measuring pain intensity.

A new instrument for measuring pain intensity--the visual analogue thermometer (VAT)--was developed to overcome limitations and disadvantages of the conventional visual analogue scale (VAS). Two studies were performed to assess the validity and utility of the VAT as compared to conventional pain instruments whose psychometric qualities are scientifically recognized. The first study was carried out with a group of 65 chronic pain patients who provided pain intensity ratings using the VAT, a standard VAS, and the McGill Pain Questionnaire. A second set of measures was obtained from a group of 243 adult healthy volunteers who quantified the intensity of a set of descriptive pain terms with the VAT, a numerical scale (NUM), and a VAS. The results of both studies support the concurrent validity of the VAT as a pain measure. When assessing changes in pain levels, the VAT was able to distinguish between different pain intensities, confirming the construct validity of the instrument. No major difference emerged in the relative sensitivity of the VAT compared to the standard VAS, both scales yielding comparable pain estimates. In contrast, the NUM scale tended to produce higher pain ratings. Regardless of the pain scale used, the results showed unequal differences between descriptive pain terms that are commonly considered equidistant on an ordinal scale. No major problem was noticed in subjects' understanding or using either the VAT, VAS, or NUM scales. When questioned about pain scale preference, a substantial number of participants preferred the VAT to the standard VAS as a means of rating pain intensity. In view of the results obtained in the present studies, it is concluded that the VAT is a valid accurate, and clinically useful tool for measuring pain. Its design makes it suitable and effective for clinical use and as an outcome measure in clinical trials.

What do older good and poor sleepers do during periods of nocturnal wakefulness? The Sleep Behaviors Scale: 60+.

To determine whether older good and poor sleepers with and without insomnia complaints differ in the nature of activities they engage in during periods of nocturnal wakefulness, the authors developed and evaluated the Sleep Behaviors Scale: 60+. Good sleepers (n = 163), low-distress poor sleepers (n = 49), and high-distress poor sleepers (n = 28) were compared on this measure as well as on sleep parameters, personality, lifestyle, and cognitive-affective variables. Findings indicate good psychometric properties for the new measure, offer a rationale for examining the frequency of the nocturnal behaviors reflected by the measure's 4 subscales (Active Behaviors, Relaxation, Cognitive Arousal, and Medication), and suggest a possible role for these behaviors in the etiology and treatment of insomnia.

Clinical documentation and occurrence of putative periodontopathic bacteria in human immunodeficiency virus-associated periodontal disease.

Human immunodeficiency virus (HIV)-associated gingivitis (HIV-G) and HIV-associated periodontitis (HIV-P) are two intraoral lesions manifested by patients with HIV infection. Periodontal indices were measured for 87 subjects in 5 study groups: HIV-seropositive patients with healthy periodontium (HIV-H), with HIV-G, or with HIV-P; and non-HIV-infected subjects with healthy periodontium (H) or with adult chronic periodontitis (P). The quantitative clinical parameters were compared and statistically significant intergroup differences were noted. The mean scores on PI and PD do not discriminate between HIV-seropositive and non-HIV-infected seronegative cohorts, but a significant difference in the GI between HIV-H and H was noted. When categories of PD and AL are examined, some differences become apparent. Generally, the PD and AL of HIV-P are not as great as those of P. PI correlates well with GI (r = 0.86) in P, but does not (r = 0.33) in HIV-P. In addition, the occurrence of selected putative periodontopathic bacteria (Porphyromonas gingivalis, spirochetes, and motile eubacteria) in these lesions was determined by brightfield (after staining), darkfield and immunofluorescent microscopy. No difference in microbiological profile in the bacterial groups monitored was found between P and HIV-P. Spirochetes were found to be more abundant than P. gingivalis in the lesions of P and HIV-P. In marked contrast, P. gingivalis was found to be in highest numbers in samples from the gingival crevice of H as determined by indirect immunofluorescence.

Effects of preparatory information of a myelogram on patients' expectations and anxiety levels.

The major purposes of this quasi-experimental study were to describe the differences between pre-myelogram anxiety levels in patients who received pre-test information and those who received no preparatory information, to examine differences in post-teaching anxiety level between patients who received "sensory information" and those who received "procedural information," to measure the degree to which patients' expectations were congruent with their actual myelogram experience, and to determine the relationship between the teaching protocols and the incidence of post-myelogram side effects. Thirty patients were randomly assigned to one of three information conditions; sensory, procedural or no information. The intervention consisted of a 5-min tape recorded message of either procedural or sensory information. Patients who received procedural information reported less anxiety than patients who received no information or sensory information. Congruence between expected and actual sensations experienced was not found. Subjects exposed to sensory information reported significantly greater number of side effects than subjects in the control or procedural groups.

Methadone maintenance: predictors of outcome in a Canadian milieu.

This hypothesis-generating study attempts to identify patient characteristics predicting the successful outcome of methadone maintenance in the treatment of narcotic addiction. The sociodemographic characteristics as well as the general emotional health of 51 addicted individuals in Montreal were studied at entry into the program and are correlated with success one year after entry. The success of the Montreal program, defined as retention in the program and urine samples negative for opiates, is comparable to results reported from many North American clinics. A history of foster care before age 15 is the only characteristic significantly correlated with both retention and negative urines. Emotional health, previous treatment experiences, job status, and level of education do not correlate with success. All addicted individuals applying to a treatment program should therefore be accepted for a trial of treatment while further research on greater numbers of subjects may eventually identify predictors of successful outcome.

Anticariogenic effects of black tea (Camellia sinensis) in caries prone-rats.

OBJECTIVE: Black tea (Camellia sinensis) may have anticariogenic properties. The present study was designed to determine whether consumption of black tea influences cariogenesis in young, caries-prone rats. METHOD AND MATERIALS: Eighteen-day-old Sprague-Dawley rats (n = 24; eight per group) fed a cariogenic diet (MIT 200) were randomly assigned to three groups to receive deionized, distilled fluoride-free water, tea, or fluoridated water (25 ppm), ad libitum, for 14 days. In addition, an initial control group of rats was studied at 20 days of age. Teeth were stained with silver nitrate to detect caries and cut mesiodistally. First and second molars were assessed for caries. RESULTS: The initial control group had negligible caries. Caries-prone rats consuming fluoride-free water had significantly more caries lesions (6.75) than did the tea (3.12) and the fluoridated water (0.85) groups. CONCLUSION: Consumption of black tea for 2 weeks attenuated development and progression of caries in caries-prone young rats.

Public awareness of physically disabled persons.

Promoting public awareness that disabled people can function independently within society is seen by many as a necessary precursor to widespread changes in accessibility, housing, and social and economic opportunities for physically disabled people. The goal of the present investigation was to empirically assess the effectiveness of a major Canadian publicity campaign which was designed to sensitize people to the needs and concerns of physically disabled people and to promote favorable attitude change. Results indicate that while the visibility of the publicity campaign can be considered a modest success, the campaign was ineffective in promoting positive attitude change. The implications of the findings for the integration of disabled people into the larger community are discussed.

Predictors of husbands' and wives' grief reactions following infant death: the role of marital intimacy.

This follow-up study examined how bereaved couples' grief reactions change over time and how the quality of the marriage can predict these reactions for men and women. A group of 31 bereaved couples who 2 to 4 years earlier had lost an infant ( greater than 20 weeks gestation and less than 1 year of age) were revisited in their home 24 months after the initial home visit. With the exception of somatization, couples' grief reactions were less intense at follow-up than at the initial visit. Overall, husbands experienced less guilt, meaninglessness, yearning, and morbid fear than wives. Both husbands and wives who reported lower levels of marital intimacy soon after the loss experienced more intense grief at follow-up. Finally, couples continued to be vulnerable to a resurgence of grief even years later.

Diagnosis of bacterial vaginosis by direct gram stain of vaginal fluid.

To determine whether bacterial vaginosis (BV), also known as nonspecific vaginitis, could be diagnosed by evaluating a Gram stain of vaginal fluid, we examined samples from 60 women of whom 25 had clinical evidence of BV and 35 had candidal vaginitis or normal examinations. An inverse relationship between the quantity of the Lactobacillus morphotype (large gram-positive rods) and of the Gardnerella morphotype (small gram-variable rods) was noted on Gram stain (P less than 0.001). When Gram stain showed a predominance (3 to 4+) of the Lactobacillus morphotype with or without the Gardnerella morphotype, it was interpreted as normal. When Gram stain showed mixed flora consisting of gram-positive, gram-negative, or gram-variable bacteria and the Lactobacillus morphotype was decreased or absent (0 to 2+), the Gram stain was interpreted as consistent with BV. Gram stain was consistent with BV in 25 of 25 women given a clinical diagnosis of BV and in none of 35 women with candidal vaginitis or normal examinations. Duplicate slides prepared from 20 additional specimens of vaginal fluid were stained by two methods and examined by three evaluators. Interevaluator interpretations and intraevaluator interpretations of duplicate slides were in agreement with one another and with the clinical diagnosis greater than or equal to 90% of the time. We concluded that a microscopically detectable change in vaginal microflora from the Lactobacillus morphotype, with or without the Gardnerella morphotype (normal), to a mixed flora with few or no Lactobacillus morphotypes (BV) can be used in the diagnosis of BV.

Professional and executive women: health and lifestyle characteristics.

Selected health characteristics of professional and executive women, and relationships among physical fitness, physical activity, and health characteristics in this group were examined. The health characteristics examined included stress, Type A patterns of behavior, substance use (alcohol, tranquilizers, and smoking), nutrition, health practices, safety, and relaxation. A convenience sample of 104 executive/professional women between the ages of 30 and 59 years, who were working full time, were administered the Canadian Standardized Test of Fitness (Step-Test) to measure cardiovascular fitness, the Framingham Type A Questionnaire, the Personal Life-style Questionnaire, the Physical Activity Questionnaire, and a visual analog scale to measure stress. The results suggest that executive women are significantly more fit than Canadian norms and that they tend to consume more alcohol and to smoke less. Demographically, they are more likely to be unmarried, childless, and have higher incomes than other Canadian women. Fitness levels are only associated (inversely) with smoking habits. Of interest are the high Type A scores, which are almost twice that of the Framingham norms. The possible consequences and implications of these findings are discussed.

The SSES-E: a measure of sexual self-efficacy in erectile functioning.

The purpose of this study was to develop and validate the Sexual Self-Efficacy Scale (SSES-E) for erectile disorder. The subjects consisted of 15 heterosexual couples with nonproblematic sexual functioning (normal group) and a sexually dysfunctional sample consisting of nine heterosexual couples and eight heterosexual single males (dysfunctional group). Most of the males in the dysfunctional sample were diagnosed as suffering from erectile disorder. Reliability of the SSES-E, based on test-retest and split-half correlations and on item analyses, appears to be reasonable. Validity, measured in three different ways, is also acceptably high. Suggestions for the use of this instrument in clinical practice and for future research are made.

Locomotory characteristics of Treponema denticola.

Locomotion of pathogenic spirochetes has been suggested as a virulence factor in their pathogenesis. Little is known of the locomotory characteristics of oral anaerobic spirochetes. We have determined the optimal conditions for motility of seven strains of Treponema denticola in menstrua of different viscosities. The viscosity for optimum motility for all strains was found to be 9.57 centipoises at 25 degrees C. Under these conditions the average speeds for each strain was computed from the motility tracks as recorded by timed exposures under dark-field microscopy. Differences in speeds were found between the various strains. In addition, we have determined the "persistence" (direct distance/actual pathlength travelled) of cell movement of each strain. Interstrain differences were also noted. These locomotory characteristics contribute to the locomotory phenotypes of the various strains and therefore may aid in their characterization and provide an insight into locomotion as a virulence factor in periodontitis.

Transurethral prostatectomy: differential effects of age category and presurgery sexual functioning on postprostatectomy sexual adjustment.

Sexual functioning and adjustment of 72 aging married males who had undergone transurethral prostatectomy were examined retrospectively according to their pre- and postsurgery status. Results indicate that although transurethral prostatectomy was generally associated with deterioration in various aspects of sexual expression, grouping subjects according to age and presurgery sexual adjustment qualified these general findings dramatically. For example, more younger than older males retained or attained good sexual adjustment after surgery. Furthermore, while older males with good presurgery sexual adjustment maintained good couple sexual functioning, they manifested greater loss of sexual self-confidence and individual sexual capacity than did their younger counterparts. In addition, the findings suggest that the question "Does transurethral prostatectomy affect sexual function?" must be rephrased to take into account changes in the cognitive, capacity, and affective domains as well as in the couple behavior and adjustment dimensions of sexual expression.

Curved anaerobic bacteria in bacterial (nonspecific) vaginosis and their response to antimicrobial therapy.

Vaginal fluid samples from normal college students, college students with bacterial (nonspecific) vaginosis, and sexually transmitted disease clinic patients with bacterial vaginosis, before and after therapy with metronidazole, ampicillin, or amoxicillin, were evaluated by direct Gram stain and culture for the predominant anaerobic and facultative flora. Curved rods were detected by direct Gram stain of vaginal fluid from 31 (51%) of 61 women with bacterial vaginosis and none of 42 normal student controls (P less than 0.001). Curved, gram-variable to gram-negative organisms were recovered from six of these 31 women, seven other women with bacterial vaginosis, and no controls. All 13 isolates were anaerobic, motile, and oxidase-negative, produced succinic acid as their major metabolic product, and hydrolyzed starch. After treatment with ampicillin or amoxicillin (n = 10) or greater than or equal to 2 g of metronidazole (n = 9), no curved motile rods were detected by Gram stain or culture, although the minimal inhibitory concentration of metronidazole was greater than or equal 8 micrograms/ml for 11 of the 13 isolates tested.