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Criminological theories and widespread assumptions about crime suggest that the modus operandi involved in sexual crimes should have changed over time given various contextual changes, such as better criminological knowledge (e.g., forensic awareness) as well as improved investigative techniques (e.g., forensic evidence analysis). The aim of this study was to test whether the modus operandi patterns of individuals having committed a sexual assault against female strangers have changed over time during the period of 2003-2017. More specifically, the study has identified changes in the trends of monthly counts and (relative) participations for sexual assaults during the study period in France. The measure of participations - a concept borrowed from the field of criminal career - was used to overcome the inherent limitations associated with this type of data. Results show that despite some significant changes in the modus operandi involved in sexual crimes, overall the modus operandi patterns appear to be fairly stable over time. The findings are discussed in light of their theoretical and practical implications.
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Vítimas de Crime , Criminosos , Delitos Sexuais , Humanos , Feminino , Crime , Psiquiatria Legal , FrançaRESUMO
OBJECTIVES: To test for statistically significant change in crime rates across neighbourhoods in Vancouver, Canada, resulting from social restrictions within the natural experiment of the COVID-19 pandemic. METHODS: Differential local Moran's I is used to identify statistically significant change in crime patterns across Vancouver's neighbourhoods because of COVID-19. These changes are analysed with variables from social disorganization theory constructs using ANOVA. RESULTS: At the neighbourhood level, all crime types have significant change during COVID, but not always at the city level. Different neighbourhoods have different changes in crime despite these changes appearing to be constant at the city level; local effects asre important to consider. Variables representing the constructs of social disorganization theory are able to predict these changes. CONCLUSIONS: COVID-19 has changed the patterns of crime in Vancouver, but most often in theoretically expected ways. Local changes are critical to understand crime during a pandemic.
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OBJECTIVES: To investigate the effect of the COVID-19 pandemic on the frequency of various crime types (property, violent, and mischief) in Vancouver, Canada. METHODS: Crime data representing residential burglary, commercial burglary, theft of vehicle, theft from vehicle, theft, violence, and mischief are analysed at the city level using interrupted time series techniques. RESULTS: While COVID-19 has not had an impact on all crime types, statistically significant change has been identified in a number of cases. Depending on the crime type, the magnitude and direction of the change in frequency varies. It is argued that (mandated) social restrictions, shifted activity patterns and opportunity structures which are responsible for these findings. CONCLUSIONS: We find support for changes in the frequency of particular crime types during the COVID-19 pandemic. This is important for criminal justice and social service practitioners when operating within an extraordinary event.
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BACKGROUND: The role of peers (former or current drug users) in reducing risky behavior within methamphetamine and crack smokers has not been well described or researched. The current study not only explores the role of peers in reducing risk factors for morbidity within the illicit drug smoking population in the Downtown Eastside (DTES) community of Vancouver but it also investigates the changes in the nature of drug use after the closure of an unsanctioned smoking facility. METHODS: The data pertain to qualitative interviews with 10 peers and 10 illicit drug smokers. The semi-structured interviews were conducted through community-based research, and the digital transcripts were analyzed via NVivo 10 software. RESULTS: The results indicate that peers (former and current drug users who are employed as educators) are instrumental in transferring risk reduction knowledge within crack and methamphetamine smokers. For example, these peers have been able to teach users about the risk of sharing pipes, using brillo, and using public drug. Furthermore, the Vancouver Area Network of Drug Users provides employment for crack and methamphetamine users in Vancouver who tend to have scarce sources of employment. However, since the closure of the unsanctioned inhalation facility, there has been significantly more public drug use and pipe sharing in the vicinity of the facility, placing drug smokers at significant risk of arrest, violence, and blood-borne infections. CONCLUSIONS: The current study recommends expanding the harm reduction peer network for people who smoke illicit drugs in the DTES community of Vancouver who have historically been underserved.
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Transtornos Relacionados ao Uso de Anfetaminas/prevenção & controle , Estimulantes do Sistema Nervoso Central , Transtornos Relacionados ao Uso de Cocaína/prevenção & controle , Cocaína Crack , Metanfetamina , Prevenção do Hábito de Fumar , Colúmbia Britânica/epidemiologia , Feminino , Redução do Dano , Humanos , Masculino , Área Carente de Assistência Médica , Pessoa de Meia-Idade , Educação de Pacientes como Assunto , Influência dos Pares , Assunção de Riscos , Fumar/epidemiologia , Centros de Tratamento de Abuso de Substâncias/estatística & dados numéricosRESUMO
Deposition of inorganic scales in wells, flow lines, and equipment is a major problem in the water treatment, geothermal, or upstream oil and gas industries. Deployment of scale inhibitors has been adopted worldwide for oilfield scale prevention. Commercial synthetic scale inhibitors such as polymeric carboxylates and sulfonates or nonpolymeric phosphonates offer good scale inhibition performance but often suffer from one or more limitations including biodegradability, calcium compatibility, and thermal stability. Lignin-based biomaterials such as sodium lignosulfonates are natural, sustainable, and widely available polymers that are accepted for use in environmentally sensitive areas. Here we show that, although lignosulfonates perform relatively poorly as calcite scale inhibitors in dynamic tube blocking tests, oxidized lignosulfonates show a much improved inhibition effect by a factor of 20-fold. The oxidized lignosulfonates are easy to prepare in a 1-step reaction and show excellent calcium compatibility and thermal stability, useful for downhole squeeze treatments in high temperature wells. This present study unequivocally establishes oxidized lignosulfonates as a new class of sustainable green scale inhibitors, thereby bridging the gap between materials derived directly from nature and the classic synthetic polymeric scale inhibitors.
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BACKGROUND: This article reports qualitative findings from a sample of 31 purposively chosen injection drug users (IDUs) from Vancouver, Surrey and Victoria, British Columbia interviewed to examine the context of safe injection site in transforming their lives. Further, the purpose is to determine whether the first and only Supervised injection facility (SIF) in North America, InSite, needs to be expanded to other cities. METHODS: Semi-structured qualitative interviews were conducted in a classical anthropological strategy of conversational format as drug users were actively involved in their routine activities. Purposive sampling combined with snowball sampling techniques was employed to recruit the participants. Audio recorded interviews were transcribed verbatim and analyzed thematically using NVivo 9 software. RESULTS: Attending InSite has numerous positive effects on the lives of IDUs including: saving lives, reducing HIV and HCV risk behavior, decreasing injection in public, reducing public syringe disposal, reducing use of various medical resources and increasing access to nursing and other primary health services. CONCLUSIONS: There is an urgent need to expand the current facility to cities where injection drug use is prevalent to reduce overdose deaths, reduce needle sharing, reduce hospital emergency care, and increase safety. In addition, InSite's positive changes have contributed to a cultural transformation in drug use within the Downtown Eastside and neighboring communities.
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Programas de Troca de Agulhas/provisão & distribuição , Abuso de Substâncias por Via Intravenosa/reabilitação , Adulto , Atitude Frente a Saúde , Colúmbia Britânica , Cidades , Feminino , Comportamentos Relacionados com a Saúde , Acessibilidade aos Serviços de Saúde , Humanos , Masculino , Pessoa de Meia-Idade , Segurança do Paciente , Relações Profissional-Paciente , Centros de Tratamento de Abuso de Substâncias/provisão & distribuiçãoRESUMO
As climate change produces more extreme weather, it is increasingly important to understand the impacts of these changes on social behaviour. The relationship between weather and crime has been studied across numerous contexts. However, few studies examine the correlation between weather and violence in southern, non-temperate climates. In addition, the literature lacks longitudinal research that controls for international changes in crime trends. In this study, we examine over 12 years of assault-related incidents in the state of Queensland, Australia. Controlling for deviations in trend for temperature and rainfall, we explore the relationship between violent crime and weather across Köppen climate classifications. Findings provide important insight into the impact of weather on violence across temperate, tropical, and arid climate regions.
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Comportamento Social , Violência , Austrália , Queensland , CrimeRESUMO
Twenty-five years ago, David Cantor and Kenneth Land presented a model of the relationship between unemployment and crime. This model showed the complexity of this seemingly simple relationship. Namely, there are two independent and counteracting effects from unemployment that affect crime: motivation and guardianship. In their analysis, Cantor and Land found that the guardianship effect dominates the motivation effect, but subsequent research has questioned this result. In this paper, the unemployment and crime relationship is tested using a neighborhood level hybrid modeling approach. Such a method allows for the nuances of Cantor and Land's model to be tested at a fine ecological resolution for the first time. It is found that both motivation and guardianship matter for crime, but at different time frames: motivation matters in the long-run whereas guardianship matters in the short-run, similar to what Cantor and Land hypothesized.
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Reversibly switchable fluorescent proteins can be repeatedly photoswitched between a fluorescent and a nonfluorescent state by irradiation with the light of two different wavelengths. The molecular basis of the switching process remains a controversial topic. Padron0.9 is a reversibly switchable fluorescent protein with "positive" switching characteristics, exhibiting excellent spectroscopic properties. Its chromophore is formed by the amino acids Cys-Tyr-Gly. We obtained high resolution x-ray structures of Padron0.9 in both the fluorescent and the nonfluorescent states and used the structural information for molecular dynamics simulations. We found that in Padron0.9 the chromophore undergoes a cis-trans isomerization upon photoswitching. The molecular dynamics simulations clarified the protonation states of the amino acid residues within the chromophore pocket that influence the protonation state of the chromophore. We conclude that a light driven cis-trans isomerization of the chromophore appears to be the fundamental switching mechanism in all photochromic fluorescent proteins known to date. Distinct absorption cross-sections for the switching wavelengths in the fluorescent and the nonfluorescent state are not essential for efficient photochromism in fluorescent proteins, although they may facilitate the switching process.
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Luz , Proteínas Luminescentes/química , Proteínas Luminescentes/metabolismo , Fotoquímica , Cristalização , Cristalografia por Raios X , Fluorescência , Imunofluorescência , Modelos Moleculares , Simulação de Dinâmica Molecular , Fótons , Conformação Proteica , Prótons , EstereoisomerismoRESUMO
The COVID-19 pandemic has dramatically affected social life. In efforts to reduce the spread of the virus, countries around the world implemented social restrictions, including social distancing, working from home, and the shuttering of numerous businesses. These social restrictions have also affected crime rates. In this study, we investigate the impact of the COVID-19 pandemic on the frequency of offending (crimes include property, violent, mischief, and miscellaneous) in Queensland, Australia. In particular, we examine this impact across numerous settings, including rural, regional and urban. We measure these shifts across the restriction period, as well as the staged relaxation of these restrictions. In order to measure impact of this period we use structural break tests. In general, we find that criminal offences have significantly decreased during the initial lockdown, but as expected, increased once social restrictions were relaxed. These findings were consistent across Queensland's districts, save for two areas. We discuss how these findings are important for criminal justice and social service practitioners when operating within an extraordinary event.
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The complex relationship between crime and economic change has had a long pedigree in criminological research. This article considers the temporal stability of the Cantor and Land model of unemployment and crime using a decomposition model of Canadian provinces, 1981 to 2009. We include multiple economic measures for a more comprehensive representation of economic performance, allowing for the estimates of long- and short-run unemployment effects to vary over time. We undertake this analysis considering 12 crime types, finding strong support for the Cantor and Land model in both property and violent crimes. However, in a number of cases, we find that there is significant variation of these relationships over time. This result implies that support for this model depends on the time period analyzed and that any policy derived from this model of unemployment and crime is time-period dependent.
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Crime/classificação , Crime/estatística & dados numéricos , Crime/tendências , Modelos Estatísticos , Desemprego/estatística & dados numéricos , Desemprego/tendências , Canadá , Crime/economia , HumanosRESUMO
One of the key photophysical properties of fluorescent proteins that is most difficult to measure is the quantum yield. It describes how efficiently a fluorophore converts absorbed light into fluorescence. Its measurement using conventional methods become particularly problematic when it is unknown how many of the proposedly fluorescent molecules of a sample are indeed fluorescent (for example due to incomplete maturation, or the presence of photophysical dark states). Here, we use a plasmonic nanocavity-based method to measure absolute quantum yield values of commonly used fluorescent proteins. The method is calibration-free, does not require knowledge about maturation or potential dark states, and works on minute amounts of sample. The insensitivity of the nanocavity-based method to the presence of non-luminescent species allowed us to measure precisely the quantum yield of photo-switchable proteins in their on-state and to analyze the origin of the residual fluorescence of protein ensembles switched to the dark state.
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Proteínas Luminescentes/química , Microscopia Confocal/instrumentação , Fotoquímica/métodos , Calibragem , Desenho de Equipamento , Fluorescência , Corantes Fluorescentes/química , Proteínas de Fluorescência Verde/química , Microscopia Confocal/métodos , Fotoquímica/instrumentação , Teoria QuânticaRESUMO
BACKGROUND: A key issue in the analysis of many spatial processes is the choice of an appropriate scale for the analysis. Smaller geographical units are generally preferable for the study of human phenomena because they are less likely to cause heterogeneous groups to be conflated. However, it can be harder to obtain data for small units and small-number problems can frustrate quantitative analysis. This research presents a new approach that can be used to estimate the most appropriate scale at which to aggregate point data to areas. DATA AND METHODS: The proposed method works by creating a number of regular grids with iteratively smaller cell sizes (increasing grid resolution) and estimating the similarity between two realisations of the point pattern at each resolution. The method is applied first to simulated point patterns and then to real publicly available crime data from the city of Vancouver, Canada. The crime types tested are residential burglary, commercial burglary, theft from vehicle and theft of bike. FINDINGS: The results provide evidence for the size of spatial unit that is the most appropriate for the different types of crime studied. Importantly, the results are dependent on both the number of events in the data and the degree of spatial clustering, so a single 'appropriate' scale is not identified. The method is nevertheless useful as a means of better estimating what spatial scale might be appropriate for a particular piece of analysis.
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Crime , Ciências Forenses , Colúmbia Britânica , Geografia , HumanosRESUMO
A foot patrol program was implemented in Lower Lonsdale, British Columbia, in the summer of 2010 and continues today. As a part of assessing the foot patrol's effect on crime in the neighbourhood, the spatial similarity was examined by comparing the crime pattern before the foot patrol initiative (2007-2009) with the crime pattern during the foot patrol program (2010-2012). Considering these baseline and treatment data sets and a spatial point pattern test, the spatial similarity between two data sets is analyzed. In general, the continued presence of foot patrol appears to have created a concentration of crime in specific areas, rather than a diffusion effect. The areas that continued to experience increased crime during foot patrol presence were often in the catchment area, suggesting displacement does occur, or along the border between the catchment and primary patrol area.
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Crime/tendências , Aplicação da Lei/métodos , Polícia , Características de Residência , Análise Espacial , HumanosRESUMO
The reporting of rape to police is an important component of this crime to have the criminal justice system involved and, potentially, punish offenders. However, for a number of reasons (fear of retribution, self-blame, etc.), most rapes are not reported to police. Most often, the research investigating this phenomenon considers incident and victim factors with little attention to the spatio-temporal factors of the rape. In this study, we consider incident, victim, and spatio-temporal factors relating to rape reporting in Campinas, Brazil. Our primary research question is whether or not the spatio-temporal factors play a significant role in the reporting of rape, over and above incident and victim factors. The subjects under study are women who were admitted to the Women's Integrated Healthcare Center at the State University of Campinas, Brazil, and surveyed by a psychologist or a social worker. Rape reporting to police was measured using a dichotomous variable. Logistic regression was used to predict the probability of rape reporting based on incident, victim, and spatio-temporal factors. Although we find that incident and victim factors matter for rape reporting, spatio-temporal factors (rape/home location and whether the rape was in a private or public place) play an important role in rape reporting, similar to the literature that considers these factors. This result has significant implications for sexual violence education. Only when we know why women decide not to report a rape may we begin to work on strategies to overcome these hurdles.
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Mulheres Maltratadas/legislação & jurisprudência , Vítimas de Crime/legislação & jurisprudência , Criminosos/legislação & jurisprudência , Estupro/legislação & jurisprudência , Saúde da Mulher/legislação & jurisprudência , Adulto , Mulheres Maltratadas/psicologia , Brasil , Vítimas de Crime/psicologia , Criminosos/psicologia , Feminino , Humanos , Polícia , Política Pública , Estupro/psicologia , Violência/legislação & jurisprudênciaRESUMO
Reversibly switchable fluorescent proteins (RSFPs) are GFP-like proteins that may be repeatedly switched by irradiation with light from a fluorescent to a nonfluorescent state, and vice versa. They can be utilized as genetically encodable probes and bear large potential for a wide array of applications, in particular for new protein tracking schemes and subdiffraction resolution microscopy. However, the currently described monomeric RSFPs emit only blue-green or green fluorescence; the spectral window for their use is thus rather limited. Using a semirational engineering approach based on the crystal structure of the monomeric nonswitchable red fluorescent protein mCherry, we generated rsCherry and rsCherryRev. These two novel red fluorescent RSFPs exhibit fluorescence emission maxima at approximately 610 nm. They display antagonistic switching modes, i.e., in rsCherry irradiation with yellow light induces the off-to-on transition and blue light the on-to-off transition, whereas in rsCherryRev the effects of the switching wavelengths are reversed. We demonstrate time-lapse live-cell subdiffraction microscopy by imaging rsCherryRev targeted to the endoplasmic reticulum utilizing the switching and localization of single molecules.
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Proteínas Luminescentes/genética , Proteínas Luminescentes/metabolismo , Nanotecnologia , Engenharia de Proteínas/métodos , Animais , Biomarcadores/metabolismo , Bovinos , Cor , Escherichia coli/citologia , Escherichia coli/genética , Luz , Microscopia , Espectrometria de Fluorescência , Fatores de Tempo , Proteína Vermelha FluorescenteRESUMO
RSFPs (reversibly switchable fluorescent proteins) may be repeatedly converted between a fluorescent and a non-fluorescent state by irradiation and have attracted widespread interest for many new applications. The RSFP Dronpa may be switched with blue light from a fluorescent state into a non-fluorescent state, and back again with UV light. To obtain insight into the underlying molecular mechanism of this switching, we have determined the crystal structure of the fluorescent equilibrium state of Dronpa. Its bicyclic chromophore is formed spontaneously from the Cys62-Tyr63-Gly64 tripeptide. In the fluorescent state, it adopts a slightly non-coplanar cis conformation within the interior of a typical GFP (green fluorescent protein) b-can fold. Dronpa shares some structural features with asFP595, another RSFP whose chromophore has previously been demonstrated to undergo a cis-trans isomerization upon photoswitching. Based on the structural comparison with asFP595, we have generated new Dronpa variants with an up to more than 1000-fold accelerated switching behaviour. The mutations which were introduced at position Val157 or Met159 apparently reduce the steric hindrance for a cis-trans isomerization of the chromophore, thus lowering the energy barrier for the blue light-driven on-to-off transition. The findings reported in the present study support the view that a cis-trans isomerization is one of the key events common to the switching mechanism in RSFPs.
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Corantes Fluorescentes/química , Proteínas Luminescentes/química , Sequência de Aminoácidos , Animais , Cristalização , Cristalografia por Raios X , Corantes Fluorescentes/metabolismo , Isomerismo , Cinética , Proteínas Luminescentes/metabolismo , Modelos Moleculares , Dados de Sequência Molecular , Pectinidae/química , Pectinidae/metabolismo , Conformação Proteica , Estrutura Terciária de Proteína , Anêmonas-do-Mar/química , Anêmonas-do-Mar/metabolismo , Alinhamento de SequênciaRESUMO
The use of social media data for the spatial analysis of crime patterns during social events has proven to be instructive. This study analyzes the geography of crime considering hockey game days, criminal behaviour, and Twitter activity. Specifically, we consider the relationship between geolocated crime-related Twitter activity and crime. We analyze six property crime types that are aggregated to the dissemination area base unit in Vancouver, for two hockey seasons through a game and non-game temporal resolution. Using the same method, geolocated Twitter messages and environmental variables are aggregated to dissemination areas. We employ spatial clustering, dictionary-based mining for tweets, spatial autocorrelation, and global and local regression models (spatial lag and geographically weighted regression). Findings show an important influence of Twitter data for theft-from-vehicle and mischief, mostly on hockey game days. Relationships from the geographically weighted regression models indicate that tweets are a valuable independent variable that can be used in explaining and understanding crime patterns.
L'utilisation des données des médias sociaux pour l'analyse spatiale des tendances de la criminalité durant des activités sociales s'est avérée très instructive. Cette étude analyse la géographie de la criminalité compte tenu des journées où il y a une partie de hockey, le comportement criminel et l'activité sur Twitter. Plus précisément, nous examinons les relations entre la criminalité et l'activité sur Twitter reliée à la criminalité géolocalisée. Nous analysons six types de crimes contre les biens qui sont agrégés par aire de diffusion à Vancouver pour deux saisons de hockey au moyen d'une résolution temporelle avec et sans partie. Utilisant la même méthode, les messages géolocalisés sur Twitter et les variables environnementales sont agrégés aux aires de diffusion. Nous utilisons le regroupement spatial, l'extraction basée sur le dictionnaire pour les gazouillis, l'autocorrélation spatiale ainsi que les modèles locaux et globaux de régression (décalage spatial et régression pondérée géographiquement). Les conclusions indiquent une influence importante des données de Twitter pour les méfaits et les vols dans les véhicules, principalement lors des journées où il y a une partie de hockey. Les relations des modèles de régression pondérée géographiquement indiquent que les gazouillis sont une variable indépendante utile qui peut être utilisée pour expliquer et comprendre les tendances de la criminalité.
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In contrast to the Canadian crime drop of the 1990s, homicide appeared as an anomaly with a peak in the 1970s. Yet previous studies tend to refer only to completed homicides, and here we also include attempts. The resulting trend is remarkably similar to that in Canadian property crime for five decades. This seems unlikely to be a coincidence and we speculate about a causal link.
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Temporal and spatial patterns of crime in Campinas, Brazil, are analyzed considering the relevance of routine activity theory in a Latin American context. We use geo-referenced criminal event data, 2010-2013, analyzing spatial patterns using census tracts and temporal patterns considering seasons, months, days, and hours. Our analyses include difference in means tests, count-based regression models, and Kulldorff's scan test. We find that crime in Campinas, Brazil, exhibits both temporal and spatial-temporal patterns. However, the presence of these patterns at the different temporal scales varies by crime type. Specifically, not all crime types have statistically significant temporal patterns at all scales of analysis. As such, routine activity theory works well to explain temporal and spatial-temporal patterns of crime in Campinas, Brazil. However, local knowledge of Brazilian culture is necessary for understanding a portion of these crime patterns.