Detalhe da pesquisa
1.
Structural basis for dual-mode inhibition of the ABC transporter MsbA.
Nature
; 557(7704): 196-201, 2018 05.
Artigo
Inglês
| MEDLINE | ID: mdl-29720648
2.
USP7 small-molecule inhibitors interfere with ubiquitin binding.
Nature
; 550(7677): 534-538, 2017 10 26.
Artigo
Inglês
| MEDLINE | ID: mdl-29045385
3.
High-Throughput Kinetic Characterization of Irreversible Covalent Inhibitors of KRASG12C by Intact Protein MS and Targeted MRM.
Anal Chem
; 94(2): 1230-1239, 2022 01 18.
Artigo
Inglês
| MEDLINE | ID: mdl-34990117
4.
Disruption of IRE1α through its kinase domain attenuates multiple myeloma.
Proc Natl Acad Sci U S A
; 116(33): 16420-16429, 2019 08 13.
Artigo
Inglês
| MEDLINE | ID: mdl-31371506
5.
Mechanism-specific assay design facilitates the discovery of Nav1.7-selective inhibitors.
Proc Natl Acad Sci U S A
; 115(4): E792-E801, 2018 01 23.
Artigo
Inglês
| MEDLINE | ID: mdl-29311306
6.
Design and synthesis of a biaryl series as inhibitors for the bromodomains of CBP/P300.
Bioorg Med Chem Lett
; 28(1): 15-23, 2018 01 01.
Artigo
Inglês
| MEDLINE | ID: mdl-29169673
7.
Discovery of Potent, Selective, and Orally Available IRE1α Inhibitors Demonstrating Comparable PD Modulation to IRE1 Knockdown in a Multiple Myeloma Model.
J Med Chem
; 2024 May 15.
Artigo
Inglês
| MEDLINE | ID: mdl-38748820
8.
Design of Organo-Peptides As Bipartite PCSK9 Antagonists.
ACS Chem Biol
; 15(2): 425-436, 2020 02 21.
Artigo
Inglês
| MEDLINE | ID: mdl-31962046
9.
Activation of the IRE1 RNase through remodeling of the kinase front pocket by ATP-competitive ligands.
Nat Commun
; 11(1): 6387, 2020 12 14.
Artigo
Inglês
| MEDLINE | ID: mdl-33318494
10.
GNE-371, a Potent and Selective Chemical Probe for the Second Bromodomains of Human Transcription-Initiation-Factor TFIID Subunit 1 and Transcription-Initiation-Factor TFIID Subunit 1-like.
J Med Chem
; 61(20): 9301-9315, 2018 10 25.
Artigo
Inglês
| MEDLINE | ID: mdl-30289257
11.
High throughput screening identifies novel, cell cycle-arresting small molecule enhancers of transient protein expression.
Biotechnol Prog
; 33(6): 1579-1588, 2017 11.
Artigo
Inglês
| MEDLINE | ID: mdl-28649725
12.
Discovery of a cryptic peptide-binding site on PCSK9 and design of antagonists.
Nat Struct Mol Biol
; 24(10): 848-856, 2017 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-28825733
13.
Therapeutic Targeting of the CBP/p300 Bromodomain Blocks the Growth of Castration-Resistant Prostate Cancer.
Cancer Res
; 77(20): 5564-5575, 2017 10 15.
Artigo
Inglês
| MEDLINE | ID: mdl-28819026
14.
A Unique Approach to Design Potent and Selective Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP) Inhibitors.
J Med Chem
; 60(24): 10151-10171, 2017 12 28.
Artigo
Inglês
| MEDLINE | ID: mdl-29155580
15.
GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP).
J Med Chem
; 60(22): 9162-9183, 2017 11 22.
Artigo
Inglês
| MEDLINE | ID: mdl-28892380
16.
Competition between intercellular adhesion molecule-1 and a small-molecule antagonist for a common binding site on the alphal subunit of lymphocyte function-associated antigen-1.
Protein Sci
; 15(2): 290-303, 2006 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-16384997
17.
Compound Transfer by Acoustic Droplet Ejection Promotes Quality and Efficiency in Ultra-High-Throughput Screening Campaigns.
J Lab Autom
; 21(1): 64-75, 2016 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-26077161
18.
Development of a Potent, Specific CDK8 Kinase Inhibitor Which Phenocopies CDK8/19 Knockout Cells.
ACS Med Chem Lett
; 7(3): 223-8, 2016 Mar 10.
Artigo
Inglês
| MEDLINE | ID: mdl-26985305
19.
Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300.
J Med Chem
; 59(23): 10549-10563, 2016 12 08.
Artigo
Inglês
| MEDLINE | ID: mdl-27682507
20.
Diving into the Water: Inducible Binding Conformations for BRD4, TAF1(2), BRD9, and CECR2 Bromodomains.
J Med Chem
; 59(11): 5391-402, 2016 06 09.
Artigo
Inglês
| MEDLINE | ID: mdl-27219867