Detalhe da pesquisa
1.
Ibrutinib induces rapid down-regulation of inflammatory markers and altered transcription of chronic lymphocytic leukaemia-related genes in blood and lymph nodes.
Br J Haematol
; 183(2): 212-224, 2018 10.
Artigo
Inglês
| MEDLINE | ID: mdl-30125946
2.
Splice-correction strategies for treatment of X-linked agammaglobulinemia.
Curr Allergy Asthma Rep
; 15(3): 510, 2015 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-25638286
3.
In BTK, phosphorylated Y223 in the SH3 domain mirrors catalytic activity, but does not influence biological function.
Blood Adv
; 8(8): 1981-1990, 2024 Apr 23.
Artigo
Inglês
| MEDLINE | ID: mdl-38507738
4.
Bruton's tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain.
Immunol Rev
; 228(1): 58-73, 2009 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-19290921
5.
The transcriptional regulator PLZF induces the development of CD44 high memory phenotype T cells.
Proc Natl Acad Sci U S A
; 105(46): 17919-24, 2008 Nov 18.
Artigo
Inglês
| MEDLINE | ID: mdl-19004789
6.
Comparative Analysis of BTK Inhibitors and Mechanisms Underlying Adverse Effects.
Front Cell Dev Biol
; 9: 630942, 2021.
Artigo
Inglês
| MEDLINE | ID: mdl-33777941
7.
Ibrutinib Has Time-dependent On- and Off-target Effects on Plasma Biomarkers and Immune Cells in Chronic Lymphocytic Leukemia.
Hemasphere
; 5(5): e564, 2021 May.
Artigo
Inglês
| MEDLINE | ID: mdl-33912812
8.
BTK gatekeeper residue variation combined with cysteine 481 substitution causes super-resistance to irreversible inhibitors acalabrutinib, ibrutinib and zanubrutinib.
Leukemia
; 35(5): 1317-1329, 2021 05.
Artigo
Inglês
| MEDLINE | ID: mdl-33526860
9.
Novel mouse model resistant to irreversible BTK inhibitors: a tool identifying new therapeutic targets and side effects.
Blood Adv
; 4(11): 2439-2450, 2020 06 09.
Artigo
Inglês
| MEDLINE | ID: mdl-32492159
10.
Transcriptional signatures of Itk-deficient CD3+, CD4+ and CD8+ T-cells.
BMC Genomics
; 10: 233, 2009 May 18.
Artigo
Inglês
| MEDLINE | ID: mdl-19450280
11.
Defective Toll-like receptor 9-mediated cytokine production in B cells from Bruton's tyrosine kinase-deficient mice.
Immunology
; 123(2): 239-49, 2008 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-17725607
12.
Splice-correcting oligonucleotides restore BTK function in X-linked agammaglobulinemia model.
J Clin Invest
; 124(9): 4067-81, 2014 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-25105368
13.
Agammaglobulinemia: causative mutations and their implications for novel therapies.
Expert Rev Clin Immunol
; 9(12): 1205-21, 2013 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-24215410
14.
Distinct gene expression signature in Btk-defective T1 B-cells.
Biochem Biophys Res Commun
; 346(2): 461-9, 2006 Jul 28.
Artigo
Inglês
| MEDLINE | ID: mdl-16764821
15.
Regulation of Bruton tyrosine kinase by the peptidylprolyl isomerase Pin1.
J Biol Chem
; 281(26): 18201-7, 2006 Jun 30.
Artigo
Inglês
| MEDLINE | ID: mdl-16644721
16.
Bruton's tyrosine kinase: cell biology, sequence conservation, mutation spectrum, siRNA modifications, and expression profiling.
Immunol Rev
; 203: 200-15, 2005 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-15661031
17.
Gene expression profile of B cells from Xid mice and Btk knockout mice.
Eur J Immunol
; 34(7): 1981-91, 2004 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-15214046
18.
Functional interaction of caveolin-1 with Bruton's tyrosine kinase and Bmx.
J Biol Chem
; 277(11): 9351-7, 2002 Mar 15.
Artigo
Inglês
| MEDLINE | ID: mdl-11751885