Detalhe da pesquisa
1.
Inhibitors of heat shock protein 70 (Hsp70) with enhanced metabolic stability reduce tau levels.
Bioorg Med Chem Lett
; 41: 128025, 2021 06 01.
Artigo
Inglês
| MEDLINE | ID: mdl-33839251
2.
Formal Total Synthesis of Pericoannosin A.
J Org Chem
; 84(18): 12187-12191, 2019 09 20.
Artigo
Inglês
| MEDLINE | ID: mdl-31436090
3.
VU6005806/AZN-00016130, an advanced M4 positive allosteric modulator (PAM) profiled as a potential preclinical development candidate.
Bioorg Med Chem Lett
; 29(14): 1714-1718, 2019 07 15.
Artigo
Inglês
| MEDLINE | ID: mdl-31113706
4.
The discovery of VU0486846: steep SAR from a series of M1 PAMs based on a novel benzomorpholine core.
Bioorg Med Chem Lett
; 28(12): 2175-2179, 2018 07 01.
Artigo
Inglês
| MEDLINE | ID: mdl-29754948
5.
Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and in vivo characterization of a series of 3-aminoazetidine-derived amides.
Bioorg Med Chem Lett
; 27(13): 2990-2995, 2017 07 01.
Artigo
Inglês
| MEDLINE | ID: mdl-28522253
6.
Optimization of the choline transporter (CHT) inhibitor ML352: Development of VU6001221, an improved in vivo tool compound.
Bioorg Med Chem Lett
; 26(19): 4637-4640, 2016 10 01.
Artigo
Inglês
| MEDLINE | ID: mdl-27575469
7.
Discovery and Optimization of a Novel Series of Competitive and Central Nervous System-Penetrant Protease-Activated Receptor 4 (PAR4) Inhibitors.
ACS Chem Neurosci
; 12(24): 4524-4534, 2021 12 15.
Artigo
Inglês
| MEDLINE | ID: mdl-34855359
8.
DARK Classics in Chemical Neuroscience: Phencyclidine (PCP).
ACS Chem Neurosci
; 9(10): 2459-2474, 2018 10 17.
Artigo
Inglês
| MEDLINE | ID: mdl-29953199
9.
A Novel M1 PAM VU0486846 Exerts Efficacy in Cognition Models without Displaying Agonist Activity or Cholinergic Toxicity.
ACS Chem Neurosci
; 9(9): 2274-2285, 2018 09 19.
Artigo
Inglês
| MEDLINE | ID: mdl-29701957