Detalhe da pesquisa
1.
Mediator complex proximal Tail subunit MED30 is critical for Mediator core stability and cardiomyocyte transcriptional network.
PLoS Genet
; 17(9): e1009785, 2021 09.
Artigo
Inglês
| MEDLINE | ID: mdl-34506481
2.
Bromodomain-Containing Protein 9 Regulates Signaling Pathways and Reprograms the Epigenome in Immortalized Human Uterine Fibroid Cells.
Int J Mol Sci
; 25(2)2024 Jan 11.
Artigo
Inglês
| MEDLINE | ID: mdl-38255982
3.
Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8/19.
J Biol Chem
; 293(13): 4870-4882, 2018 03 30.
Artigo
Inglês
| MEDLINE | ID: mdl-29440396
4.
Mediator kinase module and human tumorigenesis.
Crit Rev Biochem Mol Biol
; 50(5): 393-426, 2015.
Artigo
Inglês
| MEDLINE | ID: mdl-26182352
5.
Mediator subunit Med12 contributes to the maintenance of neural stem cell identity.
BMC Dev Biol
; 16(1): 17, 2016 05 17.
Artigo
Inglês
| MEDLINE | ID: mdl-27188461
6.
Somatic MED12 mutations in prostate cancer and uterine leiomyomas promote tumorigenesis through distinct mechanisms.
Prostate
; 76(1): 22-31, 2016 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-26383637
7.
Mutations in MED12 cause X-linked Ohdo syndrome.
Am J Hum Genet
; 92(3): 401-6, 2013 Mar 07.
Artigo
Inglês
| MEDLINE | ID: mdl-23395478
8.
Mediator links epigenetic silencing of neuronal gene expression with x-linked mental retardation.
Mol Cell
; 31(3): 347-59, 2008 Aug 08.
Artigo
Inglês
| MEDLINE | ID: mdl-18691967
9.
MED12 mutations link intellectual disability syndromes with dysregulated GLI3-dependent Sonic Hedgehog signaling.
Proc Natl Acad Sci U S A
; 109(48): 19763-8, 2012 Nov 27.
Artigo
Inglês
| MEDLINE | ID: mdl-23091001
10.
Mutations in Exon 1 highlight the role of MED12 in uterine leiomyomas.
Hum Mutat
; 35(9): 1136-41, 2014 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-24980722
11.
Lethal mitochondrial cardiomyopathy in a hypomorphic Med30 mouse mutant is ameliorated by ketogenic diet.
Proc Natl Acad Sci U S A
; 108(49): 19678-82, 2011 Dec 06.
Artigo
Inglês
| MEDLINE | ID: mdl-22106289
12.
Mediator and human disease.
Semin Cell Dev Biol
; 22(7): 776-87, 2011 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-21840410
13.
Basic helix-loop-helix transcription factor Twist1 inhibits transactivator function of master chondrogenic regulator Sox9.
J Biol Chem
; 287(25): 21082-92, 2012 Jun 15.
Artigo
Inglês
| MEDLINE | ID: mdl-22532563
14.
Transcriptional kinases: Less is more (or less).
Nat Chem Biol
; 12(1): 4-5, 2016 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-26678610
15.
Mediator is a transducer of amyloid-precursor-protein-dependent nuclear signalling.
EMBO Rep
; 12(3): 216-22, 2011 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-21293490
16.
MED12 mutation activates the tryptophan/kynurenine/AHR pathway to promote growth of uterine leiomyomas.
JCI Insight
; 8(18)2023 09 22.
Artigo
Inglês
| MEDLINE | ID: mdl-37607000
17.
The Functional Role and Regulatory Mechanism of Bromodomain-Containing Protein 9 in Human Uterine Leiomyosarcoma.
Cells
; 11(14)2022 07 10.
Artigo
Inglês
| MEDLINE | ID: mdl-35883603
18.
Targeting Class I Histone Deacetylases in Human Uterine Leiomyosarcoma.
Cells
; 11(23)2022 Nov 27.
Artigo
Inglês
| MEDLINE | ID: mdl-36497061
19.
Comprehensive Review of Uterine Fibroids: Developmental Origin, Pathogenesis, and Treatment.
Endocr Rev
; 43(4): 678-719, 2022 07 13.
Artigo
Inglês
| MEDLINE | ID: mdl-34741454
20.
Aberrant R-loop-induced replication stress in MED12-mutant uterine fibroids.
Sci Rep
; 12(1): 6169, 2022 04 13.
Artigo
Inglês
| MEDLINE | ID: mdl-35418189