Detalhe da pesquisa
1.
An anti-siglec-8 antibody depletes sputum eosinophils from asthmatic subjects and inhibits lung mast cells.
Clin Exp Allergy
; 50(8): 904-914, 2020 08.
Artigo
Inglês
| MEDLINE | ID: mdl-32542913
2.
Sialic acid-binding immunoglobulin-like lectin (Siglec) 8 in patients with eosinophilic disorders: Receptor expression and targeting using chimeric antibodies.
J Allergy Clin Immunol
; 143(6): 2227-2237.e10, 2019 06.
Artigo
Inglês
| MEDLINE | ID: mdl-30543818
3.
AK002, a Humanized Sialic Acid-Binding Immunoglobulin-Like Lectin-8 Antibody that Induces Antibody-Dependent Cell-Mediated Cytotoxicity against Human Eosinophils and Inhibits Mast Cell-Mediated Anaphylaxis in Mice.
Int Arch Allergy Immunol
; 180(2): 91-102, 2019.
Artigo
Inglês
| MEDLINE | ID: mdl-31401630
4.
The Inhibitory Receptor Siglec-8 Interacts With FcεRI and Globally Inhibits Intracellular Signaling in Primary Mast Cells Upon Activation.
Front Immunol
; 13: 833728, 2022.
Artigo
Inglês
| MEDLINE | ID: mdl-35154156
5.
Discovery of an agonistic Siglec-6 antibody that inhibits and reduces human mast cells.
Commun Biol
; 5(1): 1226, 2022 11 11.
Artigo
Inglês
| MEDLINE | ID: mdl-36369358
6.
Mast Cell and Eosinophil Activation Are Associated With COVID-19 and TLR-Mediated Viral Inflammation: Implications for an Anti-Siglec-8 Antibody.
Front Immunol
; 12: 650331, 2021.
Artigo
Inglês
| MEDLINE | ID: mdl-33777047
7.
A monoclonal antibody to Siglec-8 suppresses non-allergic airway inflammation and inhibits IgE-independent mast cell activation.
Mucosal Immunol
; 14(2): 366-376, 2021 03.
Artigo
Inglês
| MEDLINE | ID: mdl-32814824
8.
Discovery, Function, and Therapeutic Targeting of Siglec-8.
Cells
; 10(1)2020 12 24.
Artigo
Inglês
| MEDLINE | ID: mdl-33374255
9.
Neutrophils promote CXCR3-dependent itch in the development of atopic dermatitis.
Elife
; 82019 10 21.
Artigo
Inglês
| MEDLINE | ID: mdl-31631836
10.
Siglec-8 antibody reduces eosinophils and mast cells in a transgenic mouse model of eosinophilic gastroenteritis.
JCI Insight
; 4(19)2019 10 03.
Artigo
Inglês
| MEDLINE | ID: mdl-31465299