Detalhe da pesquisa
1.
Increased uptake of the P2X7 receptor radiotracer 18 F-JNJ-64413739 in the brain and peripheral organs according to the severity of status epilepticus in male mice.
Epilepsia
; 64(2): 511-523, 2023 02.
Artigo
Inglês
| MEDLINE | ID: mdl-36507708
2.
Potent and selective pharmacodynamic synergy between the metabotropic glutamate receptor subtype 2-positive allosteric modulator JNJ-46356479 and levetiracetam in the mouse 6-Hz (44-mA) model.
Epilepsia
; 59(3): 724-735, 2018 03.
Artigo
Inglês
| MEDLINE | ID: mdl-29360159
3.
Efficacy of mGlu2 -positive allosteric modulators alone and in combination with levetiracetam in the mouse 6 Hz model of psychomotor seizures.
Epilepsia
; 58(3): 484-493, 2017 03.
Artigo
Inglês
| MEDLINE | ID: mdl-28166368
4.
Pharmacology of a novel central nervous system-penetrant P2X7 antagonist JNJ-42253432.
J Pharmacol Exp Ther
; 351(3): 628-41, 2014 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-25271258
5.
Characterization of the central nervous system penetrant and selective purine P2X7 receptor antagonist JNJ-54175446 in patients with major depressive disorder.
Transl Psychiatry
; 13(1): 266, 2023 07 24.
Artigo
Inglês
| MEDLINE | ID: mdl-37482560
6.
The P2X7 receptor contributes to seizures and inflammation-driven long-lasting brain hyperexcitability following hypoxia in neonatal mice.
Br J Pharmacol
; 180(13): 1710-1729, 2023 07.
Artigo
Inglês
| MEDLINE | ID: mdl-36637008
7.
Anti-seizure effects of JNJ-54175446 in the intra-amygdala kainic acid model of drug-resistant temporal lobe epilepsy in mice.
Front Pharmacol
; 14: 1308478, 2023.
Artigo
Inglês
| MEDLINE | ID: mdl-38259288
8.
Profiling classical neuropsychiatric biomarkers across biological fluids and following continuous lumbar puncture: A guide to sample type and time.
Compr Psychoneuroendocrinol
; 10: 100116, 2022 May.
Artigo
Inglês
| MEDLINE | ID: mdl-35774109
9.
Chronic administration of P2X7 receptor antagonist JNJ-47965567 delays disease onset and progression, and improves motor performance in ALS SOD1G93A female mice.
Dis Model Mech
; 13(10)2020 10 30.
Artigo
Inglês
| MEDLINE | ID: mdl-33174532
10.
18F-JNJ-64413739, a Novel PET Ligand for the P2X7 Ion Channel: Radiation Dosimetry, Kinetic Modeling, Test-Retest Variability, and Occupancy of the P2X7 Antagonist JNJ-54175446.
J Nucl Med
; 60(5): 683-690, 2019 05.
Artigo
Inglês
| MEDLINE | ID: mdl-30262518
11.
Clinical pharmacokinetics, pharmacodynamics, safety, and tolerability of JNJ-54175446, a brain permeable P2X7 antagonist, in a randomised single-ascending dose study in healthy participants.
J Psychopharmacol
; 32(12): 1341-1350, 2018 12.
Artigo
Inglês
| MEDLINE | ID: mdl-30260294
12.
4-Methyl-6,7-dihydro-4H-triazolo[4,5-c]pyridine-Based P2X7 Receptor Antagonists: Optimization of Pharmacokinetic Properties Leading to the Identification of a Clinical Candidate.
J Med Chem
; 60(11): 4559-4572, 2017 06 08.
Artigo
Inglês
| MEDLINE | ID: mdl-28493698
13.
Efficacy and safety of an adjunctive mGlu2 receptor positive allosteric modulator to a SSRI/SNRI in anxious depression.
Prog Neuropsychopharmacol Biol Psychiatry
; 67: 66-73, 2016 Jun 03.
Artigo
Inglês
| MEDLINE | ID: mdl-26804646
14.
P2X7 receptor antagonism reduces the severity of spontaneous seizures in a chronic model of temporal lobe epilepsy.
Neuropharmacology
; 105: 175-185, 2016 06.
Artigo
Inglês
| MEDLINE | ID: mdl-26775823
15.
Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM).
J Med Chem
; 59(18): 8495-507, 2016 09 22.
Artigo
Inglês
| MEDLINE | ID: mdl-27579727
16.
Targeting neuroinflammation with brain penetrant P2X7 antagonists as novel therapeutics for neuropsychiatric disorders.
Neuropsychopharmacology
; 45(1): 234-235, 2020 01.
Artigo
Inglês
| MEDLINE | ID: mdl-31477815
17.
Dual Alleviation of Acute and Neuropathic Pain by Fused Opioid Agonist-Neurokinin 1 Antagonist Peptidomimetics.
ACS Med Chem Lett
; 6(12): 1209-14, 2015 Dec 10.
Artigo
Inglês
| MEDLINE | ID: mdl-26713106
18.
Synthesis and anti-angiogenic activity of 6-(1,2,4-thiadiazol-5-yl)-3-amino pyridazine derivatives.
Bioorg Med Chem Lett
; 12(4): 589-91, 2002 Feb 25.
Artigo
Inglês
| MEDLINE | ID: mdl-11844678