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1.
Zhongguo Zhong Yao Za Zhi ; 32(12): 1155-7, 2007 Jun.
Artigo em Chinês | MEDLINE | ID: mdl-17802874

RESUMO

OBJECTIVE: To study on effect of concentration of catalpol and 5-hydroxy methyl-2-furaldehyde (5-HMF) from Rehmanniae Radix at various processing. METHOD: The Rehmanniae Radix was dried and prepared from the steaming process with 10% ethanol, 50% ethanol at 90 degrees C and 100 degrees C each other. And the changes of catalpol and 5-HMF was determinated. The extraction of 5-HMF and catalpol was sonicated in 30% methanol for 2 h. The analysis of 5-HMF and catalpol was conducted by HPLC with reversed-phase C-18 column and detected under UV 284 nm, 204 nm. Elution was carried out at 1.0 mL min(-1) with 3% acetonitrile. RESULT: From this analysis, we found out that the content of catalpol was decreased with the number of processing times, and content of 5-HMF was increased with the number of processing times at various processing. The temperature and concentration of ethanol can effect on content of catalpol and 5-HMF at processing. The Cooked Rehmanniae Radix processed at 100 degrees C, 10% ethanol is best. And the content of 5-HMF processed for more than 7 times was accorded with standard of Korea phamcopoetia. CONCLUSION: Analyze the effect of concentration of catalpol and 5-HMF from Rehmanniae Radix at various processing, and provide the foundation for further study.


Assuntos
Furaldeído/análogos & derivados , Glucosídeos/análise , Iridoides/análise , Plantas Medicinais/química , Rehmannia/química , Cromatografia Líquida de Alta Pressão , Etanol , Furaldeído/análise , Temperatura Alta , Glucosídeos Iridoides , Tubérculos/química , Tecnologia Farmacêutica/métodos
2.
Natural Product Sciences ; : 154-161, 2016.
Artigo em Inglês | WPRIM | ID: wpr-49485

RESUMO

Phytochemical investigation on the leaves of Pileostegia viburnoides Hook.f.et Thoms led to the isolation of twenty-five compounds, and their structures were identified as n-dotriacontane (1), taraxeryl acetate (2), friedelin (3), epifriedelinol (4), canophyllal (5), stigmast-4-en-3-one (6), stigmasterol (7), (24R)-5A-stigmastane-3,6-dione (8), ursolic acid (9), pomolic acid (10), umbelliferone (11), 4-epifriedelin (12), n-octatriacontanol (13), β-amyrin (14), α-amyrin (15), taraxerol (16), nonadecanol (17), friedelane (18), arachic acid (19), protocatechuic acid (20), n-pentatriacontanol (21), hexadecanoic acid (22), vincosamide (23), daucosterol (24), and skimming (25), respectively. To our best knowledge, compounds 1, 2, 12, 13, 17 - 19 and 21-23 were new within Saxifragaceae family. Compounds 15, 16, and 20 were produced from this genus for the first time. Compounds 4, 14 and 25 were first obtained from species P. viburnoides and compounds 3, 5 - 11, and 24 were achieved from the leaves of P. viburnoides for the first time. Furthermore, the anti-neuroinflammatory activity of these isolates was evaluated.


Assuntos
Humanos , Cumarínicos , Ácido Palmítico , Saxifragaceae , Estigmasterol , Triterpenos
3.
Artigo em Inglês | WPRIM | ID: wpr-812300

RESUMO

AIM@#To investigate the cytotoxicity, anti-inflammatory activity, and action mechanism of root bark extracts of Acanthopanax henryi.@*METHOD@#The hot methanol extract of the root bark of A. henryi was subjected to XAD-4 column chromatography eluting with a gradient of methanol in water. The cytotoxicity and anti-inflammatory effects of the MeOH fractions were evaluated on the inhibition on lipopolysaccharide (LPS)-induced nitric oxide, prostaglandin E2, interleukin-1β, and interleukin-6 production in RAW 264.7 macrophages.@*RESULTS@#The 80% MeOH fraction was a better inhibitor of LPS-induced NO, PGE2, IL-1β, and IL-6 production, and expression of inducible nitric oxide synthase (iNOS) at the protein levels in a concentration-dependent manner.@*CONCLUSION@#The 80% MeOH fraction of A. henryi root bark has significant anti-inflammatory activity. This provides a pharmacological basis for clinical application for the treatment of inflammation.


Assuntos
Animais , Camundongos , Anti-Inflamatórios , Farmacologia , Usos Terapêuticos , Dinoprostona , Metabolismo , Relação Dose-Resposta a Droga , Eleutherococcus , Inflamação , Tratamento Farmacológico , Metabolismo , Interleucina-1beta , Metabolismo , Interleucina-6 , Metabolismo , Lipopolissacarídeos , Macrófagos , Metabolismo , Óxido Nítrico , Metabolismo , Óxido Nítrico Sintase Tipo II , Metabolismo , Fitoterapia , Casca de Planta , Extratos Vegetais , Farmacologia , Usos Terapêuticos , Raízes de Plantas
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