Detalhe da pesquisa
1.
Tuning the Thromboinflammatory Response to Venous Flow Interruption by the Ectonucleotidase CD39.
Arterioscler Thromb Vasc Biol
; 39(4): e118-e129, 2019 04.
Artigo
Inglês
| MEDLINE | ID: mdl-30816804
2.
Inhibition of late Na+ current, a novel target to improve diastolic function and electrical abnormalities in Dahl salt-sensitive rats.
Am J Physiol Heart Circ Physiol
; 310(10): H1313-20, 2016 05 15.
Artigo
Inglês
| MEDLINE | ID: mdl-26993228
3.
Ranolazine reduces remodeling of the right ventricle and provoked arrhythmias in rats with pulmonary hypertension.
J Pharmacol Exp Ther
; 353(3): 480-9, 2015 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-25770134
4.
The Small GTPase Rab7 Regulates Release of Mitochondria in Extracellular Vesicles in Response to Lysosomal Dysfunction.
bioRxiv
; 2023 Feb 13.
Artigo
Inglês
| MEDLINE | ID: mdl-36824711
5.
Mitochondria are secreted in extracellular vesicles when lysosomal function is impaired.
Nat Commun
; 14(1): 5031, 2023 08 18.
Artigo
Inglês
| MEDLINE | ID: mdl-37596294
6.
Strategic integration of in vivo cardiovascular models during lead optimization: predictive value of 4 models independent of species, route of administration, and influence of anesthesia.
J Cardiovasc Pharmacol
; 59(4): 369-76, 2012 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-22179024
7.
Cardiolipin Remodeling Defects Impair Mitochondrial Architecture and Function in a Murine Model of Barth Syndrome Cardiomyopathy.
Circ Heart Fail
; 14(6): e008289, 2021 06.
Artigo
Inglês
| MEDLINE | ID: mdl-34129362
8.
Ectonucleotidase tri(di)phosphohydrolase-1 (ENTPD-1) disrupts inflammasome/interleukin 1ß-driven venous thrombosis.
J Clin Invest
; 129(7): 2872-2877, 2019 04 16.
Artigo
Inglês
| MEDLINE | ID: mdl-30990798
9.
P2Y1 receptor antagonists as novel antithrombotic agents.
Bioorg Med Chem Lett
; 18(11): 3338-43, 2008 Jun 01.
Artigo
Inglês
| MEDLINE | ID: mdl-18445527
10.
Formulation modifications of PD 0313052, a direct Factor Xa Inhibitor, alter pharmacokinetics and pharma-codynamics following subcutaneous administration to rabbits.
J Pharm Pharm Sci
; 9(2): 140-8, 2006.
Artigo
Inglês
| MEDLINE | ID: mdl-16959183
11.
Long-term stability, reproducibility, and statistical sensitivity of a telemetry-instrumented dog model: A 27-month longitudinal assessment.
J Pharmacol Toxicol Methods
; 74: 26-32, 2015.
Artigo
Inglês
| MEDLINE | ID: mdl-25946685
12.
Design, synthesis, and biological activity of potent and selective inhibitors of blood coagulation factor Xa.
J Med Chem
; 47(16): 4089-99, 2004 Jul 29.
Artigo
Inglês
| MEDLINE | ID: mdl-15267248
13.
A temporal window of vulnerability for development of atrial fibrillation with advancing heart failure.
Eur J Heart Fail
; 16(3): 271-80, 2014 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-24464846
14.
Development and applications of animal models of thrombosis.
Methods Mol Med
; 93: 175-219, 2004.
Artigo
Inglês
| MEDLINE | ID: mdl-14733334
15.
The discovery of (2R,4R)-N-(4-chlorophenyl)-N- (2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl)-4-methoxypyrrolidine-1,2-dicarboxamide (PD 0348292), an orally efficacious factor Xa inhibitor.
Chem Biol Drug Des
; 70(2): 100-12, 2007 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-17683371
16.
In vitro and in vivo antithrombotic activity of PD-198961, a novel synthetic factor Xa inhibitor.
J Cardiovasc Pharmacol
; 44(4): 493-500, 2004 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-15454859
17.
Assessment of ex vivo pharmacodynamic markers during inhibition of thrombosis by CI-1031 (ZK-807834), a novel direct factor Xa inhibitor.
Pharmacology
; 64(2): 76-83, 2002 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-11803247