Detalhe da pesquisa
1.
Preclinical safety assessment of JNJ-10450232 (NTM-006), a structural analog of acetaminophen, that does not cause hepatotoxicity at supratherapeutic doses.
Regul Toxicol Pharmacol
; : 105334, 2023 Jan 04.
Artigo
Inglês
| MEDLINE | ID: mdl-36608923
2.
Population Pharmacokinetic-Pharmacodynamic Model of Oxfendazole in Healthy Adults in a Multiple Ascending Dose and Food Effect Study and Target Attainment Analysis.
Antimicrob Agents Chemother
; 66(1): e0143221, 2022 01 18.
Artigo
Inglês
| MEDLINE | ID: mdl-34606333
3.
Pharmacokinetics, Safety, and Tolerability of Oxfendazole in Healthy Adults in an Open-Label Phase 1 Multiple Ascending Dose and Food Effect Study.
Antimicrob Agents Chemother
; 64(11)2020 10 20.
Artigo
Inglês
| MEDLINE | ID: mdl-32816721
4.
Pharmacokinetics, Safety, and Tolerability of Oxfendazole in Healthy Volunteers: a Randomized, Placebo-Controlled First-in-Human Single-Dose Escalation Study.
Antimicrob Agents Chemother
; 63(4)2019 04.
Artigo
Inglês
| MEDLINE | ID: mdl-30745383
5.
Preclinical studies on the pharmacokinetics, safety, and toxicology of oxfendazole: toward first in human studies.
Int J Toxicol
; 34(2): 129-37, 2015.
Artigo
Inglês
| MEDLINE | ID: mdl-25701764
6.
JNJ-20788560 [9-(8-azabicyclo[3.2.1]oct-3-ylidene)-9H-xanthene-3-carboxylic acid diethylamide], a selective delta opioid receptor agonist, is a potent and efficacious antihyperalgesic agent that does not produce respiratory depression, pharmacologic tolerance, or physical dependence.
J Pharmacol Exp Ther
; 329(1): 241-51, 2009 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-19151246
7.
Oxfendazole: a promising agent for the treatment and control of helminth infections in humans.
Expert Rev Anti Infect Ther
; 17(1): 51-56, 2019 01.
Artigo
Inglês
| MEDLINE | ID: mdl-30501436
8.
N-pyridin-3-yl- and N-quinolin-3-yl-benzamides: modulators of human vanilloid receptor 1 (TRPV1).
Bioorg Med Chem Lett
; 18(8): 2730-4, 2008 Apr 15.
Artigo
Inglês
| MEDLINE | ID: mdl-18359227
9.
High-throughput screening for N-type calcium channel blockers using a scintillation proximity assay.
J Biomol Screen
; 11(6): 672-7, 2006 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-16831862
10.
Identification and biological evaluation of 4-(3-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid (5-trifluoromethylpyridin-2-yl)amide, a high affinity TRPV1 (VR1) vanilloid receptor antagonist.
J Med Chem
; 48(6): 1857-72, 2005 Mar 24.
Artigo
Inglês
| MEDLINE | ID: mdl-15771431
11.
Dynamic mass redistribution as a means to measure and differentiate signaling via opioid and cannabinoid receptors.
Assay Drug Dev Technol
; 9(4): 362-72, 2011 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-21323580
12.
Ex vivo delta opioid receptor autoradiography: CNS receptor occupancy of two novel compounds over their antihyperalgesic dose range.
Pharmacol Biochem Behav
; 96(2): 130-5, 2010 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-20438745
13.
Diabetogenic effect of a series of tricyclic delta opioid agonists structurally related to cyproheptadine.
Toxicol Sci
; 117(2): 493-504, 2010 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-20616206
14.
Tramadol and several anticonvulsants synergize in attenuating nerve injury-induced allodynia.
Pain
; 134(3): 254-262, 2008 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-17532139
15.
Heteroaryl beta-tetralin ureas as novel antagonists of human TRPV1.
Bioorg Med Chem Lett
; 17(22): 6160-3, 2007 Nov 15.
Artigo
Inglês
| MEDLINE | ID: mdl-17892935
16.
Molecular cloning and characterization of the human voltage-gated calcium channel alpha(2)delta-4 subunit.
Mol Pharmacol
; 62(3): 485-96, 2002 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-12181424
17.
Molecular cloning and functional expression of the human sodium channel beta1B subunit, a novel splicing variant of the beta1 subunit.
Eur J Biochem
; 270(23): 4762-70, 2003 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-14622265
18.
Design and synthesis of novel pyrrolidine-containing bradykinin antagonists.
Bioorg Med Chem Lett
; 13(11): 1879-82, 2003 Jun 02.
Artigo
Inglês
| MEDLINE | ID: mdl-12749889
19.
N,N-dialkyl-4-[(8-azabicyclo[3.2.1]-oct-3-ylidene)phenylmethyl]benzamides, potent, selective delta opioid agonists.
Bioorg Med Chem Lett
; 14(9): 2109-12, 2004 May 03.
Artigo
Inglês
| MEDLINE | ID: mdl-15080989
20.
N-alkyl-4-[(8-azabicyclo[3.2.1]-oct-3-ylidene)phenylmethyl]benzamides, micro and delta opioid agonists: a micro address.
Bioorg Med Chem Lett
; 14(9): 2113-6, 2004 May 03.
Artigo
Inglês
| MEDLINE | ID: mdl-15080990