Detalhe da pesquisa
1.
Discovery and structure-activity relationships of a novel oxazolidinone class of bacterial type II topoisomerase inhibitors.
Bioorg Med Chem Lett
; 65: 128648, 2022 06 01.
Artigo
Inglês
| MEDLINE | ID: mdl-35231579
2.
Novel Bacterial Topoisomerase Inhibitors with Potent Broad-Spectrum Activity against Drug-Resistant Bacteria.
Antimicrob Agents Chemother
; 61(5)2017 05.
Artigo
Inglês
| MEDLINE | ID: mdl-28223393
3.
Efficacy of a Novel Tricyclic Topoisomerase Inhibitor in a Murine Model of Neisseria gonorrhoeae Infection.
Antimicrob Agents Chemother
; 60(9): 5592-4, 2016 09.
Artigo
Inglês
| MEDLINE | ID: mdl-27324777
4.
Discovery and structure-activity relationships of a novel isothiazolone class of bacterial type II topoisomerase inhibitors.
Bioorg Med Chem Lett
; 26(17): 4179-83, 2016 09 01.
Artigo
Inglês
| MEDLINE | ID: mdl-27499455
5.
In Vitro Activity of Novel Topoisomerase Inhibitors against Francisella tularensis and Burkholderia pseudomallei.
Antibiotics (Basel)
; 12(6)2023 May 30.
Artigo
Inglês
| MEDLINE | ID: mdl-37370302
6.
Identification and optimisation of novel sulfonamide, selective vasopressin V1B receptor antagonists.
Bioorg Med Chem Lett
; 21(12): 3603-7, 2011 Jun 15.
Artigo
Inglês
| MEDLINE | ID: mdl-21601454
7.
Optimisation of pharmacokinetic properties to afford an orally bioavailable and selective V1A receptor antagonist.
Bioorg Med Chem Lett
; 21(15): 4622-8, 2011 Aug 01.
Artigo
Inglês
| MEDLINE | ID: mdl-21700453
8.
Synthesis and SAR studies of novel 2-(6-aminomethylaryl-2-aryl-4-oxo-quinazolin-3(4H)-yl)acetamide vasopressin V1b receptor antagonists.
Bioorg Med Chem Lett
; 21(12): 3813-7, 2011 Jun 15.
Artigo
Inglês
| MEDLINE | ID: mdl-21596563
9.
The discovery of novel 8-azabicyclo[3.2.1]octan-3-yl)-3-(4-chlorophenyl) propanamides as vasopressin V1A receptor antagonists.
Bioorg Med Chem Lett
; 21(10): 3163-7, 2011 May 15.
Artigo
Inglês
| MEDLINE | ID: mdl-21458261
10.
Synthesis and SAR studies of novel 2-(4-oxo-2-aryl-quinazolin-3(4H)-yl)acetamide vasopressin V1b receptor antagonists.
Bioorg Med Chem Lett
; 21(6): 1871-5, 2011 Mar 15.
Artigo
Inglês
| MEDLINE | ID: mdl-21353540
11.
Discovery and optimisation of a selective non-steroidal glucocorticoid receptor antagonist.
Bioorg Med Chem Lett
; 21(1): 137-40, 2011 Jan 01.
Artigo
Inglês
| MEDLINE | ID: mdl-21129964
12.
Antiglucocorticoids, neurogenesis and depression.
Mini Rev Med Chem
; 9(2): 249-64, 2009 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-19200029
13.
Teixobactin and Its Analogues: A New Hope in Antibiotic Discovery.
ACS Infect Dis
; 3(10): 688-690, 2017 10 13.
Artigo
Inglês
| MEDLINE | ID: mdl-28770988
14.
Differential effect of glucocorticoid receptor antagonists on glucocorticoid receptor nuclear translocation and DNA binding.
J Psychopharmacol
; 25(2): 211-21, 2011 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-20093322
15.
Effect of vasopressin 1b receptor blockade on the hypothalamic-pituitary-adrenal response of chronically stressed rats to a heterotypic stressor.
J Endocrinol
; 200(3): 285-91, 2009 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-19074473
16.
Glucocorticoid receptor antagonism augments fluoxetine-induced downregulation of the 5-HT transporter.
Neuropsychopharmacology
; 34(2): 399-409, 2009 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-18496518
17.
Blockade of the V(1b) receptor reduces ACTH, but not corticosterone secretion induced by stress without affecting basal hypothalamic-pituitary-adrenal axis activity.
J Endocrinol
; 200(3): 273-83, 2009 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-19008333
18.
Innovative approaches for the treatment of depression: targeting the HPA axis.
Neurochem Res
; 33(4): 691-707, 2008 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-17960478
19.
Effect of the glucocorticoid receptor antagonist Org 34850 on fast and delayed feedback of corticosterone release.
J Endocrinol
; 196(2): 323-30, 2008 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-18252955
20.
Characterization of a novel and selective V1B receptor antagonist.
Prog Brain Res
; 170: 527-35, 2008.
Artigo
Inglês
| MEDLINE | ID: mdl-18655906