Detalhe da pesquisa
1.
A novel pan-PI3K inhibitor KTC1101 synergizes with anti-PD-1 therapy by targeting tumor suppression and immune activation.
Mol Cancer
; 23(1): 54, 2024 03 14.
Artigo
Inglês
| MEDLINE | ID: mdl-38486218
2.
Discovery of novel DNA-damaging agents through phenotypic screening for DNA double-strand break.
Cancer Sci
; 114(3): 1108-1117, 2023 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-36385507
3.
Invivo anti-cancer activity of 10-methyl-aplog-1, a simplified analog of aplysiatoxin, and its possible signaling pathway associated with G1 arrest.
Biochem Biophys Res Commun
; 675: 19-25, 2023 10 01.
Artigo
Inglês
| MEDLINE | ID: mdl-37437496
4.
Structural Determination, Total Synthesis, and Biological Activity of Iezoside, a Highly Potent Ca2+-ATPase Inhibitor from the Marine Cyanobacterium Leptochromothrix valpauliae.
J Am Chem Soc
; 144(24): 11019-11032, 2022 06 22.
Artigo
Inglês
| MEDLINE | ID: mdl-35673891
5.
Synthesis of Acetogenin Analogs Comprising Pyrimidine Moieties Linked by Amine Bonds and Their Inhibitory Activity against Human Cancer Cell Lines.
Chem Pharm Bull (Tokyo)
; 70(11): 823-826, 2022.
Artigo
Inglês
| MEDLINE | ID: mdl-36328525
6.
Lamellarin 14, a derivative of marine alkaloids, inhibits the T790M/C797S mutant epidermal growth factor receptor.
Cancer Sci
; 112(5): 1963-1974, 2021 May.
Artigo
Inglês
| MEDLINE | ID: mdl-33544933
7.
(S)-Erypoegin K, an isoflavone isolated from Erythrina poeppigiana, is a novel inhibitor of topoisomerase IIα: Induction of G2 phase arrest in human gastric cancer cells.
Bioorg Med Chem
; 30: 115904, 2021 01 15.
Artigo
Inglês
| MEDLINE | ID: mdl-33341500
8.
Serum IL-8 level as a candidate prognostic marker of response to anti-angiogenic therapy for metastatic colorectal cancer.
Int J Colorectal Dis
; 36(1): 131-139, 2021 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-32920703
9.
Effects of side chain length of 10-methyl-aplog-1, a simplified analog of debromoaplysiatoxin, on PKC binding, anti-proliferative, and pro-inflammatory activities.
Biosci Biotechnol Biochem
; 85(1): 168-180, 2021 Jan 07.
Artigo
Inglês
| MEDLINE | ID: mdl-33577665
10.
Structure-Activity Relationships of Thiophene Carboxamide Annonaceous Acetogenin Analogs: Shortening the Alkyl Chain in the Tail Part Significantly Affects Their Growth Inhibitory Activity against Human Cancer Cell Lines.
Chem Pharm Bull (Tokyo)
; 69(10): 1029-1033, 2021.
Artigo
Inglês
| MEDLINE | ID: mdl-34602571
11.
Epidermal growth factor receptor mRNA expression: A potential molecular escape mechanism from regorafenib.
Cancer Sci
; 111(2): 441-450, 2020 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-31821662
12.
High-throughput screening in colorectal cancer tissue-originated spheroids.
Cancer Sci
; 110(1): 345-355, 2019 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-30343529
13.
Stereoisomer-Specific Induction of G2/M Phase Arrest and Apoptosis by 9-(E,Z)-Hydroxyoctadecadienoic Acid in Mouse Lymphoma Cells.
Biol Pharm Bull
; 42(6): 937-943, 2019.
Artigo
Inglês
| MEDLINE | ID: mdl-31155590
14.
Target Identification of Yaku'amide B and Its Two Distinct Activities against Mitochondrial FoF1-ATP Synthase.
J Am Chem Soc
; 140(38): 12189-12199, 2018 09 26.
Artigo
Inglês
| MEDLINE | ID: mdl-30156840
15.
Family-wide Analysis of the Inhibition of Arf Guanine Nucleotide Exchange Factors with Small Molecules: Evidence of Unique Inhibitory Profiles.
Biochemistry
; 56(38): 5125-5133, 2017 09 26.
Artigo
Inglês
| MEDLINE | ID: mdl-28858527
16.
M-COPA, a novel Golgi system disruptor, suppresses apoptosis induced by Shiga toxin.
Genes Cells
; 21(8): 901-6, 2016 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-27302278
17.
Loss of the Phenolic Hydroxyl Group and Aromaticity from the Side Chain of Anti-Proliferative 10-Methyl-aplog-1, a Simplified Analog of Aplysiatoxin, Enhances Its Tumor-Promoting and Proinflammatory Activities.
Molecules
; 22(4)2017 Apr 13.
Artigo
Inglês
| MEDLINE | ID: mdl-28406454
18.
Basal expression of insulin-like growth factor 1 receptor determines intrinsic resistance of cancer cells to a phosphatidylinositol 3-kinase inhibitor ZSTK474.
Cancer Sci
; 106(2): 171-8, 2015 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-25483727
19.
Comprehensive transcriptomic analysis of molecularly targeted drugs in cancer for target pathway evaluation.
Cancer Sci
; 106(7): 909-20, 2015 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-25911996
20.
Identification of a molecular target of kurahyne, an apoptosis-inducing lipopeptide from marine cyanobacterial assemblages.
Bioorg Med Chem Lett
; 25(22): 5295-8, 2015 Nov 15.
Artigo
Inglês
| MEDLINE | ID: mdl-26428873