Detalhe da pesquisa
1.
Subcellular distribution and Nrf2/Keap1-interacting properties of Glutathione S-transferase P in hepatocellular carcinoma.
Arch Biochem Biophys
; 757: 110043, 2024 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-38789086
2.
De novo NAD+ synthesis enhances mitochondrial function and improves health.
Nature
; 563(7731): 354-359, 2018 11.
Artigo
Inglês
| MEDLINE | ID: mdl-30356218
3.
3-O-Methyltolcapone and Its Lipophilic Analogues Are Potent Inhibitors of Transthyretin Amyloidogenesis with High Permeability and Low Toxicity.
Int J Mol Sci
; 25(1)2023 Dec 29.
Artigo
Inglês
| MEDLINE | ID: mdl-38203650
4.
Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells.
Nature
; 457(7225): 51-6, 2009 Jan 01.
Artigo
Inglês
| MEDLINE | ID: mdl-19122635
5.
Semisynthetic bile acid FXR and TGR5 agonists: physicochemical properties, pharmacokinetics, and metabolism in the rat.
J Pharmacol Exp Ther
; 350(1): 56-68, 2014 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-24784847
6.
An 19F NMR fragment-based approach for the discovery and development of BRCA2-RAD51 inhibitors to pursuit synthetic lethality in combination with PARP inhibition in pancreatic cancer.
Eur J Med Chem
; 265: 116114, 2024 Feb 05.
Artigo
Inglês
| MEDLINE | ID: mdl-38194775
7.
Amniotic fluid stem cell-derived extracellular vesicles educate type 2 conventional dendritic cells to rescue autoimmune disorders in a multiple sclerosis mouse model.
J Extracell Vesicles
; 13(6): e12446, 2024 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-38844736
8.
Synthesis and structure-activity relationships of amino acid conjugates of cholanic acid as antagonists of the EphA2 receptor.
Molecules
; 18(10): 13043-60, 2013 Oct 21.
Artigo
Inglês
| MEDLINE | ID: mdl-24152675
9.
Chemical exploration of TGR5 functional hot-spots: Synthesis and structure-activity relationships of C7- and C23-Substituted cholic acid derivatives.
Eur J Med Chem
; 261: 115851, 2023 Dec 05.
Artigo
Inglês
| MEDLINE | ID: mdl-37813065
10.
Pyrazole[3,4-e][1,4]thiazepin-7-one derivatives as a novel class of Farnesoid X Receptor (FXR) agonists.
Bioorg Med Chem
; 20(11): 3429-45, 2012 Jun 01.
Artigo
Inglês
| MEDLINE | ID: mdl-22564381
11.
Structural Basis of Human Dimeric α-Amino-ß-Carboxymuconate-ε-Semialdehyde Decarboxylase Inhibition With TES-1025.
Front Mol Biosci
; 9: 834700, 2022.
Artigo
Inglês
| MEDLINE | ID: mdl-35463964
12.
Identification of RAD51-BRCA2 Inhibitors Using N-Acylhydrazone-Based Dynamic Combinatorial Chemistry.
ACS Med Chem Lett
; 13(8): 1262-1269, 2022 Aug 11.
Artigo
Inglês
| MEDLINE | ID: mdl-35978685
13.
Development of 3α,7α-dihydroxy-6α-ethyl-24-nor-5ß-cholan-23-sulfate sodium salt (INT-767): Process optimization, synthesis and characterization of metabolites.
Eur J Med Chem
; 242: 114652, 2022 Nov 15.
Artigo
Inglês
| MEDLINE | ID: mdl-36049273
14.
Innovations and Emerging Therapies to Combat Renal Cell Damage: NAD+ As a Drug Target.
Antioxid Redox Signal
; 35(17): 1449-1466, 2021 12 10.
Artigo
Inglês
| MEDLINE | ID: mdl-33499758
15.
Functional characterization of the semisynthetic bile acid derivative INT-767, a dual farnesoid X receptor and TGR5 agonist.
Mol Pharmacol
; 78(4): 617-30, 2010 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-20631053
16.
Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor.
J Med Chem
; 63(7): 3701-3712, 2020 04 09.
Artigo
Inglês
| MEDLINE | ID: mdl-32160459
17.
Synthetic Lethality in Pancreatic Cancer: Discovery of a New RAD51-BRCA2 Small Molecule Disruptor That Inhibits Homologous Recombination and Synergizes with Olaparib.
J Med Chem
; 63(5): 2588-2619, 2020 03 12.
Artigo
Inglês
| MEDLINE | ID: mdl-32037829
18.
Rad51/BRCA2 disruptors inhibit homologous recombination and synergize with olaparib in pancreatic cancer cells.
Eur J Med Chem
; 165: 80-92, 2019 Mar 01.
Artigo
Inglês
| MEDLINE | ID: mdl-30660828
19.
α-Amino-ß-carboxymuconate-ε-semialdehyde Decarboxylase (ACMSD) Inhibitors as Novel Modulators of De Novo Nicotinamide Adenine Dinucleotide (NAD+) Biosynthesis.
J Med Chem
; 61(3): 745-759, 2018 02 08.
Artigo
Inglês
| MEDLINE | ID: mdl-29345930
20.
Discovery of 3α,7α,11ß-Trihydroxy-6α-ethyl-5ß-cholan-24-oic Acid (TC-100), a Novel Bile Acid as Potent and Highly Selective FXR Agonist for Enterohepatic Disorders.
J Med Chem
; 59(19): 9201-9214, 2016 Oct 13.
Artigo
Inglês
| MEDLINE | ID: mdl-27652492