Detalhe da pesquisa
1.
Degrader-antibody conjugates.
Chem Soc Rev
; 51(10): 3886-3897, 2022 May 23.
Artigo
Inglês
| MEDLINE | ID: mdl-35506708
2.
Structure-based optimization of hydroxylactam as potent, cell-active inhibitors of lactate dehydrogenase.
Bioorg Med Chem Lett
; 59: 128576, 2022 03 01.
Artigo
Inglês
| MEDLINE | ID: mdl-35065235
3.
Antibody-mediated delivery of chimeric protein degraders which target estrogen receptor alpha (ERα).
Bioorg Med Chem Lett
; 30(4): 126907, 2020 02 15.
Artigo
Inglês
| MEDLINE | ID: mdl-31902710
4.
Antibody-Drug Conjugates Derived from Cytotoxic seco-CBI-Dimer Payloads Are Highly Efficacious in Xenograft Models and Form Protein Adducts In Vivo.
Bioconjug Chem
; 30(5): 1356-1370, 2019 05 15.
Artigo
Inglês
| MEDLINE | ID: mdl-30966735
5.
Carfilzomib Is Not an Appropriate Payload of Antibody-Drug Conjugates Due to Rapid Inactivation by Lysosomal Enzymes.
Drug Metab Dispos
; 47(8): 884-889, 2019 08.
Artigo
Inglês
| MEDLINE | ID: mdl-31072822
6.
Exposure-Efficacy Analysis of Antibody-Drug Conjugates Delivering an Excessive Level of Payload to Tissues.
Drug Metab Dispos
; 47(10): 1146-1155, 2019 10.
Artigo
Inglês
| MEDLINE | ID: mdl-31358513
7.
Catalytic Cleavage of Disulfide Bonds in Small Molecules and Linkers of Antibody-Drug Conjugates.
Drug Metab Dispos
; 47(10): 1156-1163, 2019 10.
Artigo
Inglês
| MEDLINE | ID: mdl-31085544
8.
Preclinical assessment of the ADME, efficacy and drug-drug interaction potential of a novel NAMPT inhibitor.
Xenobiotica
; 49(9): 1063-1077, 2019 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-30257601
9.
Immolation of p-Aminobenzyl Ether Linker and Payload Potency and Stability Determine the Cell-Killing Activity of Antibody-Drug Conjugates with Phenol-Containing Payloads.
Bioconjug Chem
; 29(2): 267-274, 2018 02 21.
Artigo
Inglês
| MEDLINE | ID: mdl-29369629
10.
Conjugation of Indoles to Antibodies through a Novel Self-Immolating Linker.
Chemistry
; 24(19): 4830-4834, 2018 Apr 03.
Artigo
Inglês
| MEDLINE | ID: mdl-29493023
11.
Exploration of Pyrrolobenzodiazepine (PBD)-Dimers Containing Disulfide-Based Prodrugs as Payloads for Antibody-Drug Conjugates.
Mol Pharm
; 15(9): 3979-3996, 2018 09 04.
Artigo
Inglês
| MEDLINE | ID: mdl-30040421
12.
Design, synthesis, and biological evaluation of pyrrolobenzodiazepine-containing hypoxia-activated prodrugs.
Bioorg Med Chem Lett
; 27(23): 5300-5304, 2017 12 01.
Artigo
Inglês
| MEDLINE | ID: mdl-29079474
13.
From a novel HTS hit to potent, selective, and orally bioavailable KDM5 inhibitors.
Bioorg Med Chem Lett
; 27(13): 2974-2981, 2017 07 01.
Artigo
Inglês
| MEDLINE | ID: mdl-28512031
14.
Chemical Structure and Concentration of Intratumor Catabolites Determine Efficacy of Antibody Drug Conjugates.
Drug Metab Dispos
; 44(9): 1517-23, 2016 09.
Artigo
Inglês
| MEDLINE | ID: mdl-27417182
15.
Antibody Drug Conjugates Differentiate Uptake and DNA Alkylation of Pyrrolobenzodiazepines in Tumors from Organs of Xenograft Mice.
Drug Metab Dispos
; 44(12): 1958-1962, 2016 12.
Artigo
Inglês
| MEDLINE | ID: mdl-27683653
16.
Lead optimization of a pyrazolo[1,5-a]pyrimidin-7(4H)-one scaffold to identify potent, selective and orally bioavailable KDM5 inhibitors suitable for in vivo biological studies.
Bioorg Med Chem Lett
; 26(16): 4036-41, 2016 08 15.
Artigo
Inglês
| MEDLINE | ID: mdl-27406798
17.
Design and evaluation of 1,7-naphthyridones as novel KDM5 inhibitors.
Bioorg Med Chem Lett
; 26(18): 4492-4496, 2016 09 15.
Artigo
Inglês
| MEDLINE | ID: mdl-27499454
18.
Optimization of 5-(2,6-dichlorophenyl)-3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase.
Bioorg Med Chem Lett
; 25(1): 75-82, 2015 Jan 01.
Artigo
Inglês
| MEDLINE | ID: mdl-25466195
19.
Identification of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with no evidence of CYP3A4 time-dependent inhibition and improved aqueous solubility.
Bioorg Med Chem Lett
; 25(3): 529-41, 2015 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-25556090
20.
Preclinical models of nicotinamide phosphoribosyltransferase inhibitor-mediated hematotoxicity and mitigation by co-treatment with nicotinic acid.
Toxicol Mech Methods
; 25(3): 201-11, 2015 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-25894564