Detalhe da pesquisa
1.
Mechanisms of Resistance to Noncovalent Bruton's Tyrosine Kinase Inhibitors.
N Engl J Med
; 386(8): 735-743, 2022 02 24.
Artigo
Inglês
| MEDLINE | ID: mdl-35196427
2.
Preclinical characterization of pirtobrutinib, a highly selective, noncovalent (reversible) BTK inhibitor.
Blood
; 142(1): 62-72, 2023 07 06.
Artigo
Inglês
| MEDLINE | ID: mdl-36796019
3.
Author Correction: Maternal vitamin C regulates reprogramming of DNA methylation and germline development.
Nature
; 576(7785): E1, 2019 12.
Artigo
Inglês
| MEDLINE | ID: mdl-31719689
4.
Maternal vitamin C regulates reprogramming of DNA methylation and germline development.
Nature
; 573(7773): 271-275, 2019 09.
Artigo
Inglês
| MEDLINE | ID: mdl-31485074
5.
Efficacy of Selpercatinib in RET-Altered Thyroid Cancers.
N Engl J Med
; 383(9): 825-835, 2020 08 27.
Artigo
Inglês
| MEDLINE | ID: mdl-32846061
6.
Efficacy of Selpercatinib in RET Fusion-Positive Non-Small-Cell Lung Cancer.
N Engl J Med
; 383(9): 813-824, 2020 08 27.
Artigo
Inglês
| MEDLINE | ID: mdl-32846060
7.
Pirtobrutinib in relapsed or refractory B-cell malignancies (BRUIN): a phase 1/2 study.
Lancet
; 397(10277): 892-901, 2021 03 06.
Artigo
Inglês
| MEDLINE | ID: mdl-33676628
8.
Efficacy of Larotrectinib in TRK Fusion-Positive Cancers in Adults and Children.
N Engl J Med
; 378(8): 731-739, 2018 02 22.
Artigo
Inglês
| MEDLINE | ID: mdl-29466156
9.
Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells.
Nature
; 500(7461): 222-6, 2013 Aug 08.
Artigo
Inglês
| MEDLINE | ID: mdl-23812591
10.
Larotrectinib for paediatric solid tumours harbouring NTRK gene fusions: phase 1 results from a multicentre, open-label, phase 1/2 study.
Lancet Oncol
; 19(5): 705-714, 2018 05.
Artigo
Inglês
| MEDLINE | ID: mdl-29606586
11.
ETV6-NTRK3 induces aggressive acute lymphoblastic leukemia highly sensitive to selective TRK inhibition.
Blood
; 132(8): 861-865, 2018 08 23.
Artigo
Inglês
| MEDLINE | ID: mdl-29880614
12.
Soluble growth factors stimulate spermatogonial stem cell divisions that maintain a stem cell pool and produce progenitors in vitro.
Exp Cell Res
; 317(10): 1319-29, 2011 Jun 10.
Artigo
Inglês
| MEDLINE | ID: mdl-21420950
13.
The evolution of RET inhibitor resistance in RET-driven lung and thyroid cancers.
Nat Commun
; 13(1): 1450, 2022 03 18.
Artigo
Inglês
| MEDLINE | ID: mdl-35304457
14.
Overcoming MET-Dependent Resistance to Selective RET Inhibition in Patients with RET Fusion-Positive Lung Cancer by Combining Selpercatinib with Crizotinib.
Clin Cancer Res
; 27(1): 34-42, 2021 01 01.
Artigo
Inglês
| MEDLINE | ID: mdl-33082208
15.
RET Solvent Front Mutations Mediate Acquired Resistance to Selective RET Inhibition in RET-Driven Malignancies.
J Thorac Oncol
; 15(4): 541-549, 2020 04.
Artigo
Inglês
| MEDLINE | ID: mdl-31988000
16.
Resistance to TRK inhibition mediated by convergent MAPK pathway activation.
Nat Med
; 25(9): 1422-1427, 2019 09.
Artigo
Inglês
| MEDLINE | ID: mdl-31406350
17.
The application of biomarkers of spermatogonial stem cells for restoring male fertility.
Dis Markers
; 24(4-5): 267-76, 2008.
Artigo
Inglês
| MEDLINE | ID: mdl-18525121
18.
Oncogenic TRK fusions are amenable to inhibition in hematologic malignancies.
J Clin Invest
; 128(9): 3819-3825, 2018 08 31.
Artigo
Inglês
| MEDLINE | ID: mdl-29920189
19.
Vitamin C induces specific demethylation of H3K9me2 in mouse embryonic stem cells via Kdm3a/b.
Epigenetics Chromatin
; 10: 36, 2017.
Artigo
Inglês
| MEDLINE | ID: mdl-28706564
20.
A Next-Generation TRK Kinase Inhibitor Overcomes Acquired Resistance to Prior TRK Kinase Inhibition in Patients with TRK Fusion-Positive Solid Tumors.
Cancer Discov
; 7(9): 963-972, 2017 09.
Artigo
Inglês
| MEDLINE | ID: mdl-28578312