Detalhe da pesquisa
1.
Human PLD structures enable drug design and characterization of isoenzyme selectivity.
Nat Chem Biol
; 16(4): 391-399, 2020 04.
Artigo
Inglês
| MEDLINE | ID: mdl-32042197
2.
Use of Solvent Mapping for Characterizing the Binding Site and for Predicting the Inhibition of the Human Ether-á-Go-Go-Related K+ Channel.
Chem Res Toxicol
; 35(8): 1359-1369, 2022 08 15.
Artigo
Inglês
| MEDLINE | ID: mdl-35895844
3.
The influence of calculated physicochemical properties of compounds on their ADMET profiles.
Bioorg Med Chem Lett
; 36: 127825, 2021 03 15.
Artigo
Inglês
| MEDLINE | ID: mdl-33508464
4.
Design, synthesis and identification of novel, orally bioavailable non-covalent Nrf2 activators.
Bioorg Med Chem Lett
; 30(4): 126852, 2020 02 15.
Artigo
Inglês
| MEDLINE | ID: mdl-31898999
5.
Investigating small molecules to inhibit germinal center kinase-like kinase (GLK/MAP4K3) upstream of PKCθ phosphorylation: Potential therapy to modulate T cell dependent immunity.
Bioorg Med Chem Lett
; 28(10): 1964-1971, 2018 06 01.
Artigo
Inglês
| MEDLINE | ID: mdl-29636220
6.
Discovery of biaryls as RORγ inverse agonists by using structure-based design.
Bioorg Med Chem Lett
; 26(10): 2459-2463, 2016 05 15.
Artigo
Inglês
| MEDLINE | ID: mdl-27080181
7.
Discovery of novel pyrazole-containing benzamides as potent RORγ inverse agonists.
Bioorg Med Chem Lett
; 25(15): 2985-90, 2015 Aug 01.
Artigo
Inglês
| MEDLINE | ID: mdl-26048789
8.
Discovery of biaryl carboxylamides as potent RORγ inverse agonists.
Bioorg Med Chem Lett
; 25(15): 2991-7, 2015 Aug 01.
Artigo
Inglês
| MEDLINE | ID: mdl-26048806
9.
Structure-based design of low-nanomolar PIM kinase inhibitors.
Bioorg Med Chem Lett
; 25(3): 474-80, 2015 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-25575657
10.
The statistics of virtual screening and lead optimization.
J Comput Aided Mol Des
; 29(10): 923-6, 2015 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-26481649
11.
Small molecules inhibit the interaction of Nrf2 and the Keap1 Kelch domain through a non-covalent mechanism.
Bioorg Med Chem
; 21(14): 4011-9, 2013 Jul 15.
Artigo
Inglês
| MEDLINE | ID: mdl-23647822
12.
Inhibitors of protein-protein interactions: new methodologies to tackle this challenge.
Drug Discov Today Technol
; 10(4): e509-15, 2013 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-24451642
13.
Elucidation of the GSK3α Structure Informs the Design of Novel, Paralog-Selective Inhibitors.
ACS Chem Neurosci
; 14(6): 1080-1094, 2023 03 15.
Artigo
Inglês
| MEDLINE | ID: mdl-36812145
14.
Discovery of Phospholipase D Inhibitors with Improved Drug-like Properties and Central Nervous System Penetrance.
ACS Med Chem Lett
; 13(4): 665-673, 2022 Apr 14.
Artigo
Inglês
| MEDLINE | ID: mdl-35450377
15.
3,5-diarylazoles as novel and selective inhibitors of protein kinase D.
Bioorg Med Chem Lett
; 21(5): 1447-51, 2011 Mar 01.
Artigo
Inglês
| MEDLINE | ID: mdl-21300545
16.
Discovery of Potent, Selective, and Brain-Penetrant Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitors that Modulate Brain Inflammation In Vivo.
J Med Chem
; 64(20): 15402-15419, 2021 10 28.
Artigo
Inglês
| MEDLINE | ID: mdl-34653340
17.
Identification and experimental confirmation of novel cGMP efflux inhibitors by virtual ligand screening of vardenafil-analogues.
Biomed Pharmacother
; 126: 110109, 2020 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-32229414
18.
Discovery of CNS-Penetrant Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitors.
ACS Med Chem Lett
; 11(4): 485-490, 2020 Apr 09.
Artigo
Inglês
| MEDLINE | ID: mdl-32292554
19.
Identification and biochemical characterization of small-molecule inhibitors of Clostridium botulinum neurotoxin serotype A.
Antimicrob Agents Chemother
; 53(8): 3478-86, 2009 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-19528275
20.
Rational Design and Optimization of a Novel Class of Macrocyclic Apoptosis Signal-Regulating Kinase 1 Inhibitors.
J Med Chem
; 62(23): 10740-10756, 2019 12 12.
Artigo
Inglês
| MEDLINE | ID: mdl-31710475