Detalhe da pesquisa
1.
ATP-Gated P2X Receptor Channels: Molecular Insights into Functional Roles.
Annu Rev Physiol
; 81: 43-62, 2019 02 10.
Artigo
Inglês
| MEDLINE | ID: mdl-30354932
2.
Identification of a distinct desensitisation gate in the ATP-gated P2X2 receptor.
Biochem Biophys Res Commun
; 523(1): 190-195, 2020 02 26.
Artigo
Inglês
| MEDLINE | ID: mdl-31843194
3.
Mapping the Site of Action of Human P2X7 Receptor Antagonists AZ11645373, Brilliant Blue G, KN-62, Calmidazolium, and ZINC58368839 to the Intersubunit Allosteric Pocket.
Mol Pharmacol
; 96(3): 355-363, 2019 09.
Artigo
Inglês
| MEDLINE | ID: mdl-31263019
4.
Mapping the binding site of the P2X receptor antagonist PPADS reveals the importance of orthosteric site charge and the cysteine-rich head region.
J Biol Chem
; 293(33): 12820-12831, 2018 08 17.
Artigo
Inglês
| MEDLINE | ID: mdl-29997254
5.
Development of a P2X1-eYFP receptor knock-in mouse to track receptors in real time.
Purinergic Signal
; 15(3): 397-402, 2019 09.
Artigo
Inglês
| MEDLINE | ID: mdl-31286385
6.
Mapping the Allosteric Action of Antagonists A740003 and A438079 Reveals a Role for the Left Flipper in Ligand Sensitivity at P2X7 Receptors.
Mol Pharmacol
; 93(5): 553-562, 2018 05.
Artigo
Inglês
| MEDLINE | ID: mdl-29535152
7.
The P2X1 receptor is required for neutrophil extravasation during lipopolysaccharide-induced lethal endotoxemia in mice.
J Immunol
; 194(2): 739-49, 2015 Jan 15.
Artigo
Inglês
| MEDLINE | ID: mdl-25480563
8.
Contribution of the Juxtatransmembrane Intracellular Regions to the Time Course and Permeation of ATP-gated P2X7 Receptor Ion Channels.
J Biol Chem
; 290(23): 14556-66, 2015 Jun 05.
Artigo
Inglês
| MEDLINE | ID: mdl-25903136
9.
Use of chimeras, point mutants, and molecular modeling to map the antagonist-binding site of 4,4',4â³,4â´-(carbonylbis-(imino-5,1,3-benzenetriylbis(carbonylimino)))tetrakisbenzene-1,3-disulfonic acid (NF449) at P2X1 receptors for ATP.
J Biol Chem
; 290(3): 1559-69, 2015 Jan 16.
Artigo
Inglês
| MEDLINE | ID: mdl-25425641
10.
P2X1 expressed on polymorphonuclear neutrophils and platelets is required for thrombosis in mice.
Blood
; 124(16): 2575-85, 2014 Oct 16.
Artigo
Inglês
| MEDLINE | ID: mdl-25150292
11.
Calcium Signalling through Ligand-Gated Ion Channels such as P2X1 Receptors in the Platelet and other Non-Excitable Cells.
Adv Exp Med Biol
; 898: 305-29, 2016.
Artigo
Inglês
| MEDLINE | ID: mdl-27161234
12.
Male contraception via simultaneous knockout of α1A-adrenoceptors and P2X1-purinoceptors in mice.
Proc Natl Acad Sci U S A
; 110(51): 20825-30, 2013 Dec 17.
Artigo
Inglês
| MEDLINE | ID: mdl-24297884
13.
Development of a P2X1-purinoceptor mediated contractile response in the aged mouse prostate gland through slowing down of ATP breakdown.
Neurourol Urodyn
; 34(3): 292-8, 2015 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-24249481
14.
Agonist binding evokes extensive conformational changes in the extracellular domain of the ATP-gated human P2X1 receptor ion channel.
Proc Natl Acad Sci U S A
; 109(12): 4663-7, 2012 Mar 20.
Artigo
Inglês
| MEDLINE | ID: mdl-22393010
15.
Kinetics of conformational changes revealed by voltage-clamp fluorometry give insight to desensitization at ATP-gated human P2X1 receptors.
Mol Pharmacol
; 86(6): 707-15, 2014 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-25296688
16.
Ca2+ influx through P2X1 receptors amplifies P2Y1 receptor-evoked Ca2+ signaling and ADP-evoked platelet aggregation.
Mol Pharmacol
; 86(3): 243-51, 2014 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-24923466
17.
P2X receptor chimeras highlight roles of the amino terminus to partial agonist efficacy, the carboxyl terminus to recovery from desensitization, and independent regulation of channel transitions.
J Biol Chem
; 288(29): 21412-21421, 2013 Jul 19.
Artigo
Inglês
| MEDLINE | ID: mdl-23740251
18.
Heat shock protein 90 inhibitors reduce trafficking of ATP-gated P2X1 receptors and human platelet responsiveness.
J Biol Chem
; 287(39): 32747-54, 2012 Sep 21.
Artigo
Inglês
| MEDLINE | ID: mdl-22851178
19.
Identification of human P2X1 receptor-interacting proteins reveals a role of the cytoskeleton in receptor regulation.
J Biol Chem
; 286(35): 30591-30599, 2011 Sep 02.
Artigo
Inglês
| MEDLINE | ID: mdl-21757694
20.
The intracellular amino terminus plays a dominant role in desensitization of ATP-gated P2X receptor ion channels.
J Biol Chem
; 286(52): 44691-701, 2011 Dec 30.
Artigo
Inglês
| MEDLINE | ID: mdl-22027824