Detalhe da pesquisa
1.
Structural basis for the in vitro efficacy of nirmatrelvir against SARS-CoV-2 variants.
J Biol Chem
; 298(6): 101972, 2022 06.
Artigo
Inglês
| MEDLINE | ID: mdl-35461811
2.
Structure-based design of novel human Pin1 inhibitors (III): optimizing affinity beyond the phosphate recognition pocket.
Bioorg Med Chem Lett
; 24(17): 4187-91, 2014 Sep 01.
Artigo
Inglês
| MEDLINE | ID: mdl-25091930
3.
A Second-Generation Oral SARS-CoV-2 Main Protease Inhibitor Clinical Candidate for the Treatment of COVID-19.
J Med Chem
; 2024 Apr 30.
Artigo
Inglês
| MEDLINE | ID: mdl-38687966
4.
Insights into mechanism of glucokinase activation: observation of multiple distinct protein conformations.
J Biol Chem
; 287(17): 13598-610, 2012 Apr 20.
Artigo
Inglês
| MEDLINE | ID: mdl-22298776
5.
Discovery of 2-((1H-benzo[d]imidazol-1-yl)methyl)-4H-pyrido[1,2-a]pyrimidin-4-ones as novel PKM2 activators.
Bioorg Med Chem Lett
; 23(11): 3358-63, 2013 Jun 01.
Artigo
Inglês
| MEDLINE | ID: mdl-23622982
6.
Discovery of a highly potent, selective, orally bioavailable inhibitor of KAT6A/B histone acetyltransferases with efficacy against KAT6A-high ER+ breast cancer.
Cell Chem Biol
; 30(10): 1191-1210.e20, 2023 10 19.
Artigo
Inglês
| MEDLINE | ID: mdl-37557181
7.
Discovery of 3-aryloxy-lactam analogs as potent androgen receptor full antagonists for treating castration resistant prostate cancer.
Bioorg Med Chem Lett
; 22(2): 1230-6, 2012 Jan 15.
Artigo
Inglês
| MEDLINE | ID: mdl-22197140
8.
Design and synthesis of a novel pyrrolidinyl pyrido pyrimidinone derivative as a potent inhibitor of PI3Kα and mTOR.
Bioorg Med Chem Lett
; 22(15): 5098-103, 2012 Aug 01.
Artigo
Inglês
| MEDLINE | ID: mdl-22749419
9.
Quinazolines with intra-molecular hydrogen bonding scaffold (iMHBS) as PI3K/mTOR dual inhibitors.
Bioorg Med Chem Lett
; 21(4): 1270-4, 2011 Feb 15.
Artigo
Inglês
| MEDLINE | ID: mdl-21269826
10.
Novel isoquinolone PDK1 inhibitors discovered through fragment-based lead discovery.
J Comput Aided Mol Des
; 25(7): 689-98, 2011 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-21779981
11.
An oral SARS-CoV-2 Mpro inhibitor clinical candidate for the treatment of COVID-19.
Science
; 374(6575): 1586-1593, 2021 Dec 24.
Artigo
Inglês
| MEDLINE | ID: mdl-34726479
12.
Structure-based design of novel human Pin1 inhibitors (II).
Bioorg Med Chem Lett
; 20(7): 2210-4, 2010 Apr 01.
Artigo
Inglês
| MEDLINE | ID: mdl-20207139
13.
4-methylpteridinones as orally active and selective PI3K/mTOR dual inhibitors.
Bioorg Med Chem Lett
; 20(20): 6096-9, 2010 Oct 15.
Artigo
Inglês
| MEDLINE | ID: mdl-20817449
14.
Thioether benzenesulfonamide inhibitors of carbonic anhydrases II and IV: structure-based drug design, synthesis, and biological evaluation.
Bioorg Med Chem
; 18(9): 3307-19, 2010 May 01.
Artigo
Inglês
| MEDLINE | ID: mdl-20363633
15.
Characterization of Specific N-α-Acetyltransferase 50 (Naa50) Inhibitors Identified Using a DNA Encoded Library.
ACS Med Chem Lett
; 11(6): 1175-1184, 2020 Jun 11.
Artigo
Inglês
| MEDLINE | ID: mdl-32550998
16.
Structure-based design of novel human Pin1 inhibitors (I).
Bioorg Med Chem Lett
; 19(19): 5613-6, 2009 Oct 01.
Artigo
Inglês
| MEDLINE | ID: mdl-19729306
17.
Discovery of Allosteric, Potent, Subtype Selective, and Peripherally Restricted TrkA Kinase Inhibitors.
J Med Chem
; 62(1): 247-265, 2019 01 10.
Artigo
Inglês
| MEDLINE | ID: mdl-29672039
18.
Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain.
J Med Chem
; 61(15): 6779-6800, 2018 08 09.
Artigo
Inglês
| MEDLINE | ID: mdl-29944371
19.
Discovery of a Novel and Selective Indoleamine 2,3-Dioxygenase (IDO-1) Inhibitor 3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione (EOS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate.
J Med Chem
; 60(23): 9617-9629, 2017 12 14.
Artigo
Inglês
| MEDLINE | ID: mdl-29111717
20.
Discovery of aryloxy tetramethylcyclobutanes as novel androgen receptor antagonists.
J Med Chem
; 54(21): 7693-704, 2011 Nov 10.
Artigo
Inglês
| MEDLINE | ID: mdl-21936524