Detalhe da pesquisa
1.
Simple monocyclic pyrimidine analogs as microtubule targeting agents binding to the colchicine site.
Bioorg Med Chem
; 82: 117217, 2023 03 15.
Artigo
Inglês
| MEDLINE | ID: mdl-36889150
2.
Structure Guided Design, Synthesis, and Biological Evaluation of Oxetane-Containing Indole Analogues.
Bioorg Med Chem
; 92: 117400, 2023 09 07.
Artigo
Inglês
| MEDLINE | ID: mdl-37556912
3.
Novel Indole-Pyrazole Hybrids as Potential Tubulin-Targeting Agents; Synthesis, antiproliferative evaluation, and molecular modeling studies.
J Mol Struct
; 12852023 Aug 05.
Artigo
Inglês
| MEDLINE | ID: mdl-37234266
4.
The interaction of spongistatin 1 with tubulin.
Arch Biochem Biophys
; 727: 109296, 2022 09 30.
Artigo
Inglês
| MEDLINE | ID: mdl-35594923
5.
Design, Synthesis, and Biological Evaluation of 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidines as Microtubule Targeting Agents.
Molecules
; 27(1)2022 Jan 05.
Artigo
Inglês
| MEDLINE | ID: mdl-35011550
6.
Novel pyrazolo[4,3-d]pyrimidine microtubule targeting agents (MTAs): Synthesis, structure-activity relationship, in vitro and in vivo evaluation as antitumor agents.
Bioorg Med Chem Lett
; 41: 127923, 2021 06 01.
Artigo
Inglês
| MEDLINE | ID: mdl-33705908
7.
Potential of substituted quinazolines to interact with multiple targets in the treatment of cancer.
Bioorg Med Chem
; 35: 116061, 2021 04 01.
Artigo
Inglês
| MEDLINE | ID: mdl-33647840
8.
The 3-D conformational shape of N-naphthyl-cyclopenta[d]pyrimidines affects their potency as microtubule targeting agents and their antitumor activity.
Bioorg Med Chem
; 29: 115887, 2021 01 01.
Artigo
Inglês
| MEDLINE | ID: mdl-33310545
9.
Concise synthesis and biological evaluation of 2-Aryl-3-Anilinobenzo[b]thiophene derivatives as potent apoptosis-inducing agents.
Bioorg Chem
; 112: 104919, 2021 07.
Artigo
Inglês
| MEDLINE | ID: mdl-33957538
10.
Interaction of diazonamide A with tubulin.
Arch Biochem Biophys
; 680: 108217, 2020 02 15.
Artigo
Inglês
| MEDLINE | ID: mdl-31830440
11.
Bioreductively Activatable Prodrug Conjugates of Combretastatin A-1 and Combretastatin A-4 as Anticancer Agents Targeted toward Tumor-Associated Hypoxia.
J Nat Prod
; 83(4): 937-954, 2020 04 24.
Artigo
Inglês
| MEDLINE | ID: mdl-32196334
12.
New complex polycyclic compounds: Synthesis, antiproliferative activity and mechanism of action.
Bioorg Chem
; 101: 103989, 2020 08.
Artigo
Inglês
| MEDLINE | ID: mdl-32563004
13.
Diaryl disulfides and thiosulfonates as combretastatin A-4 analogues: Synthesis, cytotoxicity and antitubulin activity.
Bioorg Chem
; 101: 104017, 2020 08.
Artigo
Inglês
| MEDLINE | ID: mdl-32629276
14.
Design, synthesis and biological evaluation of 2-alkoxycarbonyl-3-anilinoindoles as a new class of potent inhibitors of tubulin polymerization.
Bioorg Chem
; 97: 103665, 2020 04.
Artigo
Inglês
| MEDLINE | ID: mdl-32086053
15.
Synthesis and Biological Evaluation of New Antitubulin Agents Containing 2-(3',4',5'-trimethoxyanilino)-3,6-disubstituted-4,5,6,7-tetrahydrothieno[2,3-c]pyridine Scaffold.
Molecules
; 25(7)2020 Apr 07.
Artigo
Inglês
| MEDLINE | ID: mdl-32272719
16.
Synthesis and Biological Evaluation of 2-Substituted Benzyl-/Phenylethylamino-4-amino-5-aroylthiazoles as Apoptosis-Inducing Anticancer Agents.
Molecules
; 25(9)2020 May 06.
Artigo
Inglês
| MEDLINE | ID: mdl-32384805
17.
Antiproliferative Aspidosperma-Type Monoterpenoid Indole Alkaloids from Bousigonia mekongensis Inhibit Tubulin Polymerization.
Molecules
; 24(7)2019 Mar 31.
Artigo
Inglês
| MEDLINE | ID: mdl-30935100
18.
Design, synthesis and preclinical evaluation of 5-methyl-N4-aryl-furo[2,3-d]pyrimidines as single agents with combination chemotherapy potential.
Bioorg Med Chem Lett
; 28(18): 3085-3093, 2018 10 01.
Artigo
Inglês
| MEDLINE | ID: mdl-30098869
19.
Structure based drug design and in vitro metabolism study: Discovery of N-(4-methylthiophenyl)-N,2-dimethyl-cyclopenta[d]pyrimidine as a potent microtubule targeting agent.
Bioorg Med Chem
; 26(9): 2437-2451, 2018 05 15.
Artigo
Inglês
| MEDLINE | ID: mdl-29655610
20.
Sterically induced conformational restriction: Discovery and preclinical evaluation of novel pyrrolo[3,2-d]pyrimidines as microtubule targeting agents.
Bioorg Med Chem
; 26(20): 5470-5478, 2018 11 01.
Artigo
Inglês
| MEDLINE | ID: mdl-30297118