Detalhe da pesquisa
1.
Discovery and Characterization of VU0542270, the First Selective Inhibitor of Vascular Kir6.1/SUR2B KATP Channels.
Mol Pharmacol
; 105(3): 202-212, 2024 Feb 15.
Artigo
Inglês
| MEDLINE | ID: mdl-38302135
2.
Redefining Health Care Data Interoperability: Empirical Exploration of Large Language Models in Information Exchange.
J Med Internet Res
; 26: e56614, 2024 May 31.
Artigo
Inglês
| MEDLINE | ID: mdl-38819879
3.
Synthesis and SAR of a novel Kir6.2/SUR1 channel opener scaffold identified by HTS.
Bioorg Med Chem Lett
; 87: 129256, 2023 05 01.
Artigo
Inglês
| MEDLINE | ID: mdl-36966977
4.
Changes in the Circadian Rhythm of High-Frequency Heart Rate Variability Associated With Depression.
J Korean Med Sci
; 38(19): e142, 2023 May 15.
Artigo
Inglês
| MEDLINE | ID: mdl-37191846
5.
VU6036720: The First Potent and Selective In Vitro Inhibitor of Heteromeric Kir4.1/5.1 Inward Rectifier Potassium Channels.
Mol Pharmacol
; 101(5): 357-370, 2022 05.
Artigo
Inglês
| MEDLINE | ID: mdl-35246480
6.
Discovery of a potent M5 antagonist with improved clearance profile. Part 2: Pyrrolidine amide-based antagonists.
Bioorg Med Chem Lett
; 78: 129021, 2022 12 15.
Artigo
Inglês
| MEDLINE | ID: mdl-36228968
7.
Discovery of a potent M5 antagonist with improved clearance profile. Part 1: Piperidine amide-based antagonists.
Bioorg Med Chem Lett
; 76: 128988, 2022 11 15.
Artigo
Inglês
| MEDLINE | ID: mdl-36113671
8.
Automated Detection of Acute Myocardial Infarction Using Asynchronous Electrocardiogram Signals-Preview of Implementing Artificial Intelligence With Multichannel Electrocardiographs Obtained From Smartwatches: Retrospective Study.
J Med Internet Res
; 23(9): e31129, 2021 09 10.
Artigo
Inglês
| MEDLINE | ID: mdl-34505839
9.
Controlling the Cleavage of Carbon-Carbon Bonds To Generate α,α-Difluorobenzyl Carbanions for the Construction of Difluoromethylbenzenes.
J Org Chem
; 84(18): 11665-11675, 2019 09 20.
Artigo
Inglês
| MEDLINE | ID: mdl-31449418
10.
SAR inspired by aldehyde oxidase (AO) metabolism: Discovery of novel, CNS penetrant tricyclic M4 PAMs.
Bioorg Med Chem Lett
; 29(16): 2224-2228, 2019 08 15.
Artigo
Inglês
| MEDLINE | ID: mdl-31248774
11.
Optimization of M4 positive allosteric modulators (PAMs): The discovery of VU0476406, a non-human primate in vivo tool compound for translational pharmacology.
Bioorg Med Chem Lett
; 27(11): 2296-2301, 2017 06 01.
Artigo
Inglês
| MEDLINE | ID: mdl-28442253
12.
Conversion of Methyl Ketones and Methyl Sulfones into α-Deutero-α,α-Difluoromethyl Ketones and α-Deutero-α,α-Difluoromethyl Sulfones in Three Synthetic Steps.
Tetrahedron Lett
; 58(5): 396-400, 2017 02 01.
Artigo
Inglês
| MEDLINE | ID: mdl-28943667
13.
Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5,6-dimethyl-4-(piperidin-1-yl)thieno[2,3-d]pyrimidine core.
Bioorg Med Chem Lett
; 26(13): 3029-3033, 2016 07 01.
Artigo
Inglês
| MEDLINE | ID: mdl-27185330
14.
Gentle Sampling of Submicrometer Airborne Virus Particles using a Personal Electrostatic Particle Concentrator.
Environ Sci Technol
; 50(22): 12365-12372, 2016 11 15.
Artigo
Inglês
| MEDLINE | ID: mdl-27786464
15.
Progress towards small molecule menin-mixed lineage leukemia (MLL) interaction inhibitors with in vivo utility.
Bioorg Med Chem Lett
; 25(13): 2720-5, 2015 Jul 01.
Artigo
Inglês
| MEDLINE | ID: mdl-25987377
16.
Discovery and SAR of muscarinic receptor subtype 1 (M1) allosteric activators from a molecular libraries high throughput screen. Part 1: 2,5-dibenzyl-2H-pyrazolo[4,3-c]quinolin-3(5H)-ones as positive allosteric modulators.
Bioorg Med Chem Lett
; 25(2): 384-8, 2015 Jan 15.
Artigo
Inglês
| MEDLINE | ID: mdl-25435150
17.
An Explainable Artificial Intelligence-enabled ECG Framework for the Prediction of Subclinical Coronary Atherosclerosis.
AMIA Jt Summits Transl Sci Proc
; 2024: 535-544, 2024.
Artigo
Inglês
| MEDLINE | ID: mdl-38827057
18.
Evaluation of GPT-4 for 10-year cardiovascular risk prediction: Insights from the UK Biobank and KoGES data.
iScience
; 27(2): 109022, 2024 Feb 16.
Artigo
Inglês
| MEDLINE | ID: mdl-38357664
19.
Machine learning with clinical and intraoperative biosignal data for predicting postoperative delirium after cardiac surgery.
iScience
; 27(6): 109932, 2024 Jun 21.
Artigo
Inglês
| MEDLINE | ID: mdl-38799563
20.
Structure-Based Discovery of Potent, Orally Bioavailable Benzoxazepinone-Based WD Repeat Domain 5 Inhibitors.
J Med Chem
; 66(24): 16783-16806, 2023 12 28.
Artigo
Inglês
| MEDLINE | ID: mdl-38085679