Detalhe da pesquisa
1.
Discovery of trypanocidal coumarins with dual inhibition of both the glycerol kinase and alternative oxidase of Trypanosoma brucei brucei.
FASEB J
; 33(11): 13002-13013, 2019 11.
Artigo
Inglês
| MEDLINE | ID: mdl-31525300
2.
Biochemical studies of membrane bound Plasmodium falciparum mitochondrial L-malate:quinone oxidoreductase, a potential drug target.
Biochim Biophys Acta Bioenerg
; 1859(3): 191-200, 2018 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-29269266
3.
Expression, purification, and crystallization of type 1 isocitrate dehydrogenase from Trypanosoma brucei brucei.
Protein Expr Purif
; 138: 56-62, 2017 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-28642005
4.
Glycerol kinase of African trypanosomes possesses an intrinsic phosphatase activity.
Biochim Biophys Acta Gen Subj
; 1861(11 Pt A): 2830-2842, 2017 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-28778484
5.
Design and synthesis of potent substrate-based inhibitors of the Trypanosoma cruzi dihydroorotate dehydrogenase.
Bioorg Med Chem
; 25(4): 1465-1470, 2017 02 15.
Artigo
Inglês
| MEDLINE | ID: mdl-28118956
6.
Structure of the trypanosome cyanide-insensitive alternative oxidase.
Proc Natl Acad Sci U S A
; 110(12): 4580-5, 2013 Mar 19.
Artigo
Inglês
| MEDLINE | ID: mdl-23487766
7.
Probing the ubiquinol-binding site of recombinant Sauromatum guttatum alternative oxidase expressed in E. coli membranes through site-directed mutagenesis.
Biochim Biophys Acta
; 1837(7): 1219-25, 2014 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-24530866
8.
Molecular basis for the reverse reaction of African human trypanosomes glycerol kinase.
Mol Microbiol
; 94(6): 1315-29, 2014 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-25315291
9.
Structural Insights into the Molecular Design of Flutolanil Derivatives Targeted for Fumarate Respiration of Parasite Mitochondria.
Int J Mol Sci
; 16(7): 15287-308, 2015 Jul 07.
Artigo
Inglês
| MEDLINE | ID: mdl-26198225
10.
Diversity of parasite complex II.
Biochim Biophys Acta
; 1827(5): 658-67, 2013 May.
Artigo
Inglês
| MEDLINE | ID: mdl-23333273
11.
Mitochondrial fumarate reductase as a target of chemotherapy: from parasites to cancer cells.
Biochim Biophys Acta
; 1820(5): 643-51, 2012 May.
Artigo
Inglês
| MEDLINE | ID: mdl-22226661
12.
The alternative oxidases: simple oxidoreductase proteins with complex functions.
Biochem Soc Trans
; 41(5): 1305-11, 2013 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-24059524
13.
Identification and characterization of sialidase-like activity in the developmental stages of Amblyomma variegatum.
J Med Entomol
; 50(1): 85-93, 2013 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-23427656
14.
Essential role of Duox in stabilization of Drosophila wing.
J Biol Chem
; 286(38): 33244-51, 2011 Sep 23.
Artigo
Inglês
| MEDLINE | ID: mdl-21808060
15.
Critical importance of the de novo pyrimidine biosynthesis pathway for Trypanosoma cruzi growth in the mammalian host cell cytoplasm.
Biochem Biophys Res Commun
; 417(3): 1002-6, 2012 Jan 20.
Artigo
Inglês
| MEDLINE | ID: mdl-22209850
16.
Molecular interaction of the first 3 enzymes of the de novo pyrimidine biosynthetic pathway of Trypanosoma cruzi.
Biochem Biophys Res Commun
; 418(1): 140-3, 2012 Feb 03.
Artigo
Inglês
| MEDLINE | ID: mdl-22245425
17.
The role of amino acid residues in the active site of L-methionine γ-lyase from Pseudomonas putida.
Biosci Biotechnol Biochem
; 76(7): 1275-84, 2012.
Artigo
Inglês
| MEDLINE | ID: mdl-22785484
18.
Purification and kinetic characterization of recombinant alternative oxidase from Trypanosoma brucei brucei.
Biochim Biophys Acta
; 1797(4): 443-50, 2010 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-20056101
19.
A Drosophila model for the screening of bioavailable NADPH oxidase inhibitors and antioxidants.
Mol Cell Biochem
; 352(1-2): 91-8, 2011 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-21312054
20.
Functional importance of crenarchaea-specific extra-loop revealed by an X-ray structure of a heterotetrameric crenarchaeal splicing endonuclease.
Nucleic Acids Res
; 37(14): 4787-98, 2009 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-19515941