Detalhe da pesquisa
1.
Chronic pharmacological antagonism of the GM-CSF receptor in mice does not replicate the pulmonary alveolar proteinosis phenotype but does alter lung surfactant turnover.
Clin Sci (Lond)
; 135(22): 2559-2573, 2021 11 26.
Artigo
Inglês
| MEDLINE | ID: mdl-34778899
2.
Humanised effector-null FcγRIIA antibody inhibits immune complex-mediated proinflammatory responses.
Ann Rheum Dis
; 78(2): 228-237, 2019 02.
Artigo
Inglês
| MEDLINE | ID: mdl-30459279
3.
Interpreting and Integrating Clinical and Anatomic Pathology Results.
Toxicol Pathol
; 45(1): 223-237, 2017 01.
Artigo
Inglês
| MEDLINE | ID: mdl-27879439
4.
Choice of Starting Dose for Biopharmaceuticals in First-in-Human Phase I Cancer Clinical Trials.
Oncologist
; 20(6): 653-9, 2015 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-25964306
5.
Nonclinical safety of mavrilimumab, an anti-GMCSF receptor alpha monoclonal antibody, in cynomolgus monkeys: relevance for human safety.
Toxicol Appl Pharmacol
; 279(2): 230-9, 2014 Sep 01.
Artigo
Inglês
| MEDLINE | ID: mdl-24937321
6.
Phase I Study of MEDI3726: A Prostate-Specific Membrane Antigen-Targeted Antibody-Drug Conjugate, in Patients with mCRPC after Failure of Abiraterone or Enzalutamide.
Clin Cancer Res
; 27(13): 3602-3609, 2021 07 01.
Artigo
Inglês
| MEDLINE | ID: mdl-33795255
7.
HER2-targeted antibody-drug conjugate induces host immunity against cancer stem cells.
Cell Chem Biol
; 28(5): 610-624.e5, 2021 05 20.
Artigo
Inglês
| MEDLINE | ID: mdl-33711257
8.
Patient Selection Strategies to Maximize Therapeutic Index of Antibody-Drug Conjugates: Prior Approaches and Future Directions.
Mol Cancer Ther
; 19(9): 1770-1783, 2020 09.
Artigo
Inglês
| MEDLINE | ID: mdl-32546659
9.
Design and characterization of homogenous antibody-drug conjugates with a drug-to-antibody ratio of one prepared using an engineered antibody and a dual-maleimide pyrrolobenzodiazepine dimer.
MAbs
; 11(3): 500-515, 2019 04.
Artigo
Inglês
| MEDLINE | ID: mdl-30835621
10.
Antitumor Activity of MEDI3726 (ADCT-401), a Pyrrolobenzodiazepine Antibody-Drug Conjugate Targeting PSMA, in Preclinical Models of Prostate Cancer.
Mol Cancer Ther
; 17(10): 2176-2186, 2018 10.
Artigo
Inglês
| MEDLINE | ID: mdl-30065100
11.
Fractionated Dosing Improves Preclinical Therapeutic Index of Pyrrolobenzodiazepine-Containing Antibody Drug Conjugates.
Clin Cancer Res
; 23(19): 5858-5868, 2017 Oct 01.
Artigo
Inglês
| MEDLINE | ID: mdl-28630216
12.
Preclinical Evaluation of MEDI0641, a Pyrrolobenzodiazepine-Conjugated Antibody-Drug Conjugate Targeting 5T4.
Mol Cancer Ther
; 16(8): 1576-1587, 2017 08.
Artigo
Inglês
| MEDLINE | ID: mdl-28522587
13.
Rational design, biophysical and biological characterization of site-specific antibody-tubulysin conjugates with improved stability, efficacy and pharmacokinetics.
J Control Release
; 236: 100-16, 2016 08 28.
Artigo
Inglês
| MEDLINE | ID: mdl-27327768
14.
A Biparatopic HER2-Targeting Antibody-Drug Conjugate Induces Tumor Regression in Primary Models Refractory to or Ineligible for HER2-Targeted Therapy.
Cancer Cell
; 29(1): 117-29, 2016 Jan 11.
Artigo
Inglês
| MEDLINE | ID: mdl-26766593
15.
Antibody Drug Conjugates: Nonclinical Safety Considerations.
AAPS J
; 17(5): 1055-64, 2015 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-26024656
16.
A Biparatopic HER2-Targeting Antibody-Drug Conjugate Induces Tumor Regression in Primary Models Refractory to or Ineligible for HER2-Targeted Therapy.
Cancer Cell
; 35(6): 948-949, 2019 Jun 10.
Artigo
Inglês
| MEDLINE | ID: mdl-31185215