Case Report of Spontaneous Bilateral Ovarian Pregnancy in a Nulliparous Lady.

Nontubal ectopic pregnancies, especially ovarian ones, are rare. Here, we report a case of spontaneous bilateral ovarian pregnancy in a 23-year-old nulliparous lady who presented with a three-day history of abdominal pain localized to the right iliac fossa. Laboratory investigations and pelvic US and transvaginal US findings were suggestive of a right ovarian ectopic pregnancy and left ovarian cyst. Following the patient's consent, the gynaecologist laparoscopically removed the right ovarian ectopic pregnancy and performed a left ovarian cystectomy. Histopathology revealed findings of trophoblastic tissue and chorionic villi with products of conception in both ovaries leading to the diagnosis of bilateral spontaneous ectopic pregnancy. Physicians must be mindful in cases that have a similar clinical presentation because an early diagnosis leads to a reduction in the morbidity and mortality of this specific patient population and helps to improve their overall prognosis.

Stimulation and inhibition of 5 ALA induced PplX fluorescence in the diagnosis of fibrosarcoma cultivated on the CAM using glucose versus ethanol as modulating agents.

The fluorescence properties of biological tissues have been considered as intrinsic parameters to discriminate diseased from normal conditions. In vivo fluorescence diagnosis of cancer is based on special fluorescent dyes and their properties of tumour selective retention. The experimental in vivo model of the chorioallantoic membrane (CAM) of chicken embryos was used for cultivating a murine tumourous system consisting of the SSK II fibrosarcoma. Proto porphyrine (PplX) synthesis in CAM inoculated tissues as well as in native CAM was induced by 5-ALA. The modulation effects of several biochemicals on the 5-ALA induced PplX production were tested. The fibrosarcoma cells have not revealed autofluorescence with distinctively higher signal intensities than the substrate tissue. Fibrosarcoma cells are clearly distinguished by higher xenofluorescence intensities compared to the CAM tissue in the background. 5-ALA induced xenofluorescence intensity in fibrosarcoma was significantly enhanced by glucose and inhibited by ethanol. It can be concluded that some chemical agents can modulate the intensity of 5-ALA induced xenofluorescence through their modulation the enzymatic cell activity and these can be used for improvement by varying both the diagnostic and the therapeutic effectiveness of the photosensitizers in its application in the photo therapy process.