Detalhe da pesquisa
1.
An mTORC1-to-CDK1 Switch Maintains Autophagy Suppression during Mitosis.
Mol Cell
; 77(2): 228-240.e7, 2020 01 16.
Artigo
Inglês
| MEDLINE | ID: mdl-31733992
2.
ERK1/2 inhibitors act as monovalent degraders inducing ubiquitylation and proteasome-dependent turnover of ERK2, but not ERK1.
Biochem J
; 480(9): 587-605, 2023 05 15.
Artigo
Inglês
| MEDLINE | ID: mdl-37018014
3.
DUSP5-mediated inhibition of smooth muscle cell proliferation suppresses pulmonary hypertension and right ventricular hypertrophy.
Am J Physiol Heart Circ Physiol
; 321(2): H382-H389, 2021 08 01.
Artigo
Inglês
| MEDLINE | ID: mdl-34142888
4.
Dual-specificity phosphatase 5 controls the localized inhibition, propagation, and transforming potential of ERK signaling.
Proc Natl Acad Sci U S A
; 114(3): E317-E326, 2017 01 17.
Artigo
Inglês
| MEDLINE | ID: mdl-28053233
5.
The regulation of oncogenic Ras/ERK signalling by dual-specificity mitogen activated protein kinase phosphatases (MKPs).
Semin Cell Dev Biol
; 50: 125-32, 2016 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-26791049
6.
Visualization of Endogenous ERK1/2 in Cells with a Bioorthogonal Covalent Probe.
Bioconjug Chem
; 28(6): 1677-1683, 2017 06 21.
Artigo
Inglês
| MEDLINE | ID: mdl-28449575
7.
Dual-specificity phosphatase 5 regulates nuclear ERK activity and suppresses skin cancer by inhibiting mutant Harvey-Ras (HRasQ61L)-driven SerpinB2 expression.
Proc Natl Acad Sci U S A
; 111(51): 18267-72, 2014 Dec 23.
Artigo
Inglês
| MEDLINE | ID: mdl-25489104
8.
Suppression of mutant Kirsten-RAS (KRASG12D)-driven pancreatic carcinogenesis by dual-specificity MAP kinase phosphatases 5 and 6.
Oncogene
; 41(20): 2811-2823, 2022 05.
Artigo
Inglês
| MEDLINE | ID: mdl-35418690
9.
Paradoxical activation of the protein kinase-transcription factor ERK5 by ERK5 kinase inhibitors.
Nat Commun
; 11(1): 1383, 2020 03 13.
Artigo
Inglês
| MEDLINE | ID: mdl-32170057
10.
Dual-Mechanism ERK1/2 Inhibitors Exploit a Distinct Binding Mode to Block Phosphorylation and Nuclear Accumulation of ERK1/2.
Mol Cancer Ther
; 19(2): 525-539, 2020 02.
Artigo
Inglês
| MEDLINE | ID: mdl-31748345
11.
Dual-specificity MAP kinase phosphatases in health and disease.
Biochim Biophys Acta Mol Cell Res
; 1866(1): 124-143, 2019 01.
Artigo
Inglês
| MEDLINE | ID: mdl-30401534
12.
De-RSKing ERK - regulation of ERK1/2-RSK dissociation by phosphorylation within a disordered motif.
FEBS J
; 285(1): 42-45, 2018 01.
Artigo
Inglês
| MEDLINE | ID: mdl-29314599
13.
ERK1/2 inhibitors: New weapons to inhibit the RAS-regulated RAF-MEK1/2-ERK1/2 pathway.
Pharmacol Ther
; 187: 45-60, 2018 07.
Artigo
Inglês
| MEDLINE | ID: mdl-29454854
14.
Visualizing and Quantitating the Spatiotemporal Regulation of Ras/ERK Signaling by Dual-Specificity Mitogen-Activated Protein Phosphatases (MKPs).
Methods Mol Biol
; 1447: 197-215, 2016.
Artigo
Inglês
| MEDLINE | ID: mdl-27514808