Detalhe da pesquisa
1.
Kinase domain autophosphorylation rewires the activity and substrate specificity of CK1 enzymes.
Mol Cell
; 82(11): 2006-2020.e8, 2022 06 02.
Artigo
Inglês
| MEDLINE | ID: mdl-35353987
2.
CDK11 regulates pre-mRNA splicing by phosphorylation of SF3B1.
Nature
; 609(7928): 829-834, 2022 09.
Artigo
Inglês
| MEDLINE | ID: mdl-36104565
3.
Structural Insights into Pseudokinase Domains of Receptor Tyrosine Kinases.
Mol Cell
; 79(3): 390-405.e7, 2020 08 06.
Artigo
Inglês
| MEDLINE | ID: mdl-32619402
4.
Small-molecule inhibition of BRDT for male contraception.
Cell
; 150(4): 673-84, 2012 Aug 17.
Artigo
Inglês
| MEDLINE | ID: mdl-22901802
5.
Histone recognition and large-scale structural analysis of the human bromodomain family.
Cell
; 149(1): 214-31, 2012 Mar 30.
Artigo
Inglês
| MEDLINE | ID: mdl-22464331
6.
A chemical probe to modulate human GID4 Pro/N-degron interactions.
Nat Chem Biol
; 2024 May 21.
Artigo
Inglês
| MEDLINE | ID: mdl-38773330
7.
DNA damage in oocytes induces a switch of the quality control factor TAp63α from dimer to tetramer.
Cell
; 144(4): 566-76, 2011 Feb 18.
Artigo
Inglês
| MEDLINE | ID: mdl-21335238
8.
LRRK2 dynamics analysis identifies allosteric control of the crosstalk between its catalytic domains.
PLoS Biol
; 20(2): e3001427, 2022 02.
Artigo
Inglês
| MEDLINE | ID: mdl-35192607
9.
Disrupted Binding of Cystathionine γ-Lyase to p53 Promotes Endothelial Senescence.
Circ Res
; 133(10): 842-857, 2023 10 27.
Artigo
Inglês
| MEDLINE | ID: mdl-37800327
10.
Nanobodies as allosteric modulators of Parkinson's disease-associated LRRK2.
Proc Natl Acad Sci U S A
; 119(9)2022 03 01.
Artigo
Inglês
| MEDLINE | ID: mdl-35217606
11.
Expanding the ligand spaces for E3 ligases for the design of protein degraders.
Bioorg Med Chem
; 105: 117718, 2024 May 01.
Artigo
Inglês
| MEDLINE | ID: mdl-38621319
12.
Synthesis and biological evaluation of 1H-pyrrolo[3,2-g]isoquinolines.
Bioorg Med Chem
; 100: 117619, 2024 Feb 15.
Artigo
Inglês
| MEDLINE | ID: mdl-38320389
13.
Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell
; 136(2): 352-63, 2009 Jan 23.
Artigo
Inglês
| MEDLINE | ID: mdl-19167335
14.
Conformation and dynamics of the kinase domain drive subcellular location and activation of LRRK2.
Proc Natl Acad Sci U S A
; 118(23)2021 06 08.
Artigo
Inglês
| MEDLINE | ID: mdl-34088839
15.
Mutation in Abl kinase with altered drug-binding kinetics indicates a novel mechanism of imatinib resistance.
Proc Natl Acad Sci U S A
; 118(46)2021 11 16.
Artigo
Inglês
| MEDLINE | ID: mdl-34750265
16.
Toward effective Atg8-based ATTECs: Approaches and perspectives.
J Cell Biochem
; 2023 Feb 13.
Artigo
Inglês
| MEDLINE | ID: mdl-36780422
17.
Targeting the Alternative Vitamin E Metabolite Binding Site Enables Noncanonical PPARγ Modulation.
J Am Chem Soc
; 145(27): 14802-14810, 2023 07 12.
Artigo
Inglês
| MEDLINE | ID: mdl-37385602
18.
Structural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activation.
Cell
; 134(5): 793-803, 2008 Sep 05.
Artigo
Inglês
| MEDLINE | ID: mdl-18775312
19.
Oxazolo[5,4-f]quinoxaline-type selective inhibitors of glycogen synthase kinase-3α (GSK-3α): Development and impact on temozolomide treatment of glioblastoma cells.
Bioorg Chem
; 134: 106456, 2023 05.
Artigo
Inglês
| MEDLINE | ID: mdl-36913879
20.
PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase domain.
Biochem J
; 479(18): 1941-1965, 2022 09 30.
Artigo
Inglês
| MEDLINE | ID: mdl-36040231