Detalhe da pesquisa
1.
Discovery of macrocyclic HDACs 1, 2, and 3 selective inhibitors for HIV latency reactivation.
Bioorg Med Chem Lett
; 47: 128168, 2021 09 01.
Artigo
Inglês
| MEDLINE | ID: mdl-34091041
2.
Development of a selective HDAC inhibitor aimed at reactivating the HIV latent reservoir.
Bioorg Med Chem Lett
; 30(17): 127367, 2020 09 01.
Artigo
Inglês
| MEDLINE | ID: mdl-32738976
3.
Discovery of ethyl ketone-based HDACs 1, 2, and 3 selective inhibitors for HIV latency reactivation.
Bioorg Med Chem Lett
; 30(13): 127197, 2020 07 01.
Artigo
Inglês
| MEDLINE | ID: mdl-32331932
4.
Potent, non-covalent reversible BTK inhibitors with 8-amino-imidazo[1,5-a]pyrazine core featuring 3-position bicyclic ring substitutes.
Bioorg Med Chem Lett
; 30(17): 127390, 2020 09 01.
Artigo
Inglês
| MEDLINE | ID: mdl-32738973
5.
Discovery of novel pan-genotypic HCV NS5A inhibitors containing a novel tetracyclic core.
Bioorg Med Chem Lett
; 29(5): 700-706, 2019 03 01.
Artigo
Inglês
| MEDLINE | ID: mdl-30711390
6.
In Vitro Antiviral Profile of Ruzasvir, a Potent and Pangenotype Inhibitor of Hepatitis C Virus NS5A.
Antimicrob Agents Chemother
; 62(11)2018 11.
Artigo
Inglês
| MEDLINE | ID: mdl-30150466
7.
MK-8325: A silyl proline-containing NS5A inhibitor with pan-genotype activity for treatment of HCV.
Bioorg Med Chem Lett
; 28(10): 1954-1957, 2018 06 01.
Artigo
Inglês
| MEDLINE | ID: mdl-29653894
8.
Development of a prodrug of hydantoin based TACE inhibitor.
Bioorg Med Chem Lett
; 27(16): 3704-3708, 2017 08 15.
Artigo
Inglês
| MEDLINE | ID: mdl-28711352
9.
Fused bi-heteroaryl substituted hydantoin compounds as TACE inhibitors.
Bioorg Med Chem Lett
; 27(14): 3037-3042, 2017 07 15.
Artigo
Inglês
| MEDLINE | ID: mdl-28558971
10.
Discovery of 3-morpholino-imidazole[1,5-a]pyrazine BTK inhibitors for rheumatoid arthritis.
Bioorg Med Chem Lett
; 27(16): 3939-3943, 2017 08 15.
Artigo
Inglês
| MEDLINE | ID: mdl-28720503
11.
Alternative core development around the tetracyclic indole class of HCV NS5A inhibitors.
Bioorg Med Chem Lett
; 26(20): 5132-5137, 2016 10 15.
Artigo
Inglês
| MEDLINE | ID: mdl-27634194
12.
Aryl or heteroaryl substituted aminal derivatives of HCV NS5A inhibitor MK-8742.
Bioorg Med Chem Lett
; 26(15): 3414-20, 2016 08 01.
Artigo
Inglês
| MEDLINE | ID: mdl-27394665
13.
Matched and mixed cap derivatives in the tetracyclic indole class of HCV NS5A inhibitors.
Bioorg Med Chem Lett
; 26(16): 4106-11, 2016 08 15.
Artigo
Inglês
| MEDLINE | ID: mdl-27423481
14.
Alkyl substituted aminal derivatives of HCV NS5A inhibitor MK-8742.
Bioorg Med Chem Lett
; 26(15): 3800-5, 2016 08 01.
Artigo
Inglês
| MEDLINE | ID: mdl-27282742
15.
Discovery of potent macrocyclic HCV NS5A inhibitors.
Bioorg Med Chem Lett
; 26(15): 3793-9, 2016 08 01.
Artigo
Inglês
| MEDLINE | ID: mdl-27282743
16.
Substituted tetracyclic indole core derivatives of HCV NS5A inhibitor MK-8742.
Bioorg Med Chem Lett
; 26(19): 4851-4856, 2016 10 01.
Artigo
Inglês
| MEDLINE | ID: mdl-27568086
17.
Structure-activity relationships of proline modifications around the tetracyclic-indole class of NS5A inhibitors.
Bioorg Med Chem Lett
; 26(21): 5354-5360, 2016 11 01.
Artigo
Inglês
| MEDLINE | ID: mdl-27680588
18.
Discovery of fused tricyclic core containing HCV NS5A inhibitors with pan-genotype activity.
Bioorg Med Chem Lett
; 26(13): 3158-3162, 2016 07 01.
Artigo
Inglês
| MEDLINE | ID: mdl-27180013
19.
Discovery of silyl proline containing HCV NS5A inhibitors with pan-genotype activity: SAR development.
Bioorg Med Chem Lett
; 26(5): 1475-9, 2016 Mar 01.
Artigo
Inglês
| MEDLINE | ID: mdl-26850003
20.
IV. Discovery of CXCR3 antagonists substituted with heterocycles as amide surrogates: improved PK, hERG and metabolic profiles.
Bioorg Med Chem Lett
; 24(4): 1085-8, 2014 Feb 15.
Artigo
Inglês
| MEDLINE | ID: mdl-24486132