Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 33
Filtrar
1.
Br J Psychiatry ; 212(1): 1-3, 2018 01.
Artigo em Inglês | MEDLINE | ID: mdl-29433614

RESUMO

According to the experience of people with schizophrenia, their psychiatrists' attitude towards the outcome of their illness is lacking in hope, which directly affects mutual faith in treatment. Here we discuss the scientific basis of hope and show its instrumental role in optimising the best treatment strategies for schizophrenia. Declaration of interest R.A.B has received honoraria for educational input and non-financial support from Ache; honoraria for educational input from Lundbeck; grants, honoraria for educational input and non-financial support from Janssen; all outside the submitted work. G.E.M.G. has received honoraria for educational input and non-financial support from Janssen outside the submitted work. G.M. reports support from Janssen-Cilag, outside the submitted work, and is an employee at Janssen-Cilag. S.S. has received grants and honoraria for educational input from EnVivo Pharmaceuticals, Takeda, AbbVie and Janssen Pharmaceuticals, outside the submitted work.


Assuntos
Atitude do Pessoal de Saúde , Médicos , Psiquiatria , Esquizofrenia/terapia , Esperança , Humanos
2.
Epilepsia ; 54(4): 644-8, 2013 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-23398523

RESUMO

PURPOSE: Female sexual function is complex and may be disrupted by disease, in particular epilepsy. Chronic seizures in women can have adverse effects on reproductive function, but it has been difficult to dissociate the effects of epilepsy from those related to anticonvulsant medications. The purpose of this study was to evaluate sexual behavior in female rats submitted to pilocarpine-induced status epilepticus (SE). METHODS: Adult female Wistar rats were given saline or pilocarpine (350 mg/kg, i.p.) to induce SE. The groups were distributed according to the treatment or response to pilocarpine: CTRL (control rats maintained in the home-cage after saline administration); NSE (non-status epilepticus, rats that did not display convulsive and intermittent seizures after pilocarpine injection) and SE (status epilepticus, rats that displayed convulsive and intermittent seizures after pilocarpine injection). After 50 days, sexual receptivity in the female rats was artificially induced via administration of a combination of estradiol and progesterone. Sexual behavior was evaluated during three sessions in the presence of a sexually experienced male rat. Receptivity and proceptivity behaviors, as well as hormones concentrations, were monitored. KEY FINDINGS: Significant decreases in proceptivity and receptivity behaviors during the three tests were observed in SE female rats. The rejection response was significantly increased in SE rats compared with CTRL or NSE groups. Progesterone, testosterone, and corticosterone were unchanged between the groups. SIGNIFICANCE: The SE female rats showed lower sexual motivation and performance regardless of their steroid hormones levels.


Assuntos
Comportamento Sexual Animal/fisiologia , Estado Epiléptico/psicologia , Análise de Variância , Animais , Corticosterona/sangue , Modelos Animais de Doenças , Feminino , Hormônios Esteroides Gonadais/sangue , Antagonistas Muscarínicos , Pilocarpina , Progesterona/sangue , Ratos , Disfunções Sexuais Fisiológicas/etiologia , Estado Epiléptico/induzido quimicamente , Estado Epiléptico/complicações , Testosterona/sangue
3.
Epilepsy Behav ; 27(2): 378-84, 2013 May.
Artigo em Inglês | MEDLINE | ID: mdl-23542896

RESUMO

Sleep and epilepsy present a bidirectional interaction. Sleep complaints are common in epilepsy, and sleep deprivation may provoke seizures. However, the mechanisms underlying this relationship are unknown. Thus, this study investigated the effects of paradoxical sleep deprivation (PSD24h) and total sleep deprivation (TSD6h) in the expression of genes related to reactive oxygen species and nitric oxide production in the frontal cortex of a rodent model of temporal lobe epilepsy (PILO). The data show that PILO rats had increased NOX-2 expression and decreased SOD expression, independent of sleep. Higher NOX-2 expression was observed only in PILO rats subjected to the control condition and TSD6h. Also, eNOS and DDAH1 were increased in the PILO group submitted to TSD6h. Moreover, CAT expression in the frontal cortex of PILO rats submitted to PSD24h was reduced compared to that of PILO rats that were not sleep-deprived. The molecular changes found in the frontal cortex of PILO rats following sleep deprivation suggest a mechanism via oxidative stress.


Assuntos
Lobo Frontal/metabolismo , Regulação da Expressão Gênica/fisiologia , Privação do Sono , Estado Epiléptico/patologia , Amidoidrolases/genética , Amidoidrolases/metabolismo , Análise de Variância , Enzima de Conversão de Angiotensina 2 , Animais , Catalase/genética , Catalase/metabolismo , Modelos Animais de Doenças , Regulação da Expressão Gênica/efeitos dos fármacos , Glicoproteínas de Membrana/genética , Glicoproteínas de Membrana/metabolismo , Agonistas Muscarínicos/toxicidade , NADPH Oxidase 2 , NADPH Oxidases/genética , NADPH Oxidases/metabolismo , Óxido Nítrico Sintase Tipo III/genética , Óxido Nítrico Sintase Tipo III/metabolismo , Peptidil Dipeptidase A/genética , Peptidil Dipeptidase A/metabolismo , Pilocarpina/toxicidade , RNA Mensageiro/metabolismo , Ratos , Sono REM , Estado Epiléptico/induzido quimicamente , Superóxido Dismutase/metabolismo , Fatores de Tempo
4.
Epilepsy Behav ; 26(3): 405-9, 2013 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-23394796

RESUMO

The relationship between sleep and epilepsy has been well established. There is a high prevalence of sleep disturbances in epilepsy, which are associated with a decreased quality of life of individuals with epilepsy. In view of this fact, preclinical research is necessary to address many gaps in knowledge. For instance, it is well known that sleep deprivation can trigger seizures; however, this is a complex pathophysiological event. In this context, there are many valuable animal models of epilepsy that reproduce clinical symptoms and can be used. Investigations using animal models that simulate clinical epilepsy are imperative. Furthermore, preclinical studies that reveal mechanisms related to sleep-epilepsy interactions are very important. Results of such studies can, in turn, improve the understanding of epilepsy itself and can be useful in developing new antiepileptic drugs and preventive measures to control seizures. Preclinical research should be performed using a translational framework with experimental designs that can lead to advances in the quality of life of individuals with epilepsy. In view of the fact that more than 50 million of people are affected by epilepsy around the world, understanding the relationship between sleep and epilepsy is imperative.


Assuntos
Epilepsia/complicações , Transtornos do Sono-Vigília/complicações , Transtornos do Sono-Vigília/etiologia , Sono/fisiologia , Animais , Anticonvulsivantes/farmacologia , Modelos Animais de Doenças , Avaliação Pré-Clínica de Medicamentos , Epilepsia/etiologia , Epilepsia/terapia , Humanos , Sono/efeitos dos fármacos
5.
Epilepsy Behav ; 28(1): 47-51, 2013 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-23657213

RESUMO

The aim of this study was to investigate the association between physical activity levels (occupational, sports, and leisure time activities), depression, anxiety, and epilepsy. The behavioral outcomes of individuals with epilepsy (E) were also compared with healthy control subjects (C). The sample included 31 individuals with epilepsy (12 with idiopathic generalized epilepsy and 19 with partial epilepsy) and 31 control subjects. Self-rating questionnaires were used to assess mood (State-Trait Anxiety Inventory and Beck Depression Inventory), anxiety, and depression as well as habitual physical activity. Patients with epilepsy were more severely impaired compared to control subjects in both mood questionnaires and presented higher levels of depression (35%), state anxiety (18%), and trait anxiety (12.6%) when compared to the C group. Although physical activity level did not differ significantly between groups, linear regression analyses showed that the physical activity leisure level predicted 31% of depression levels and 26% of anxiety levels in the E group. These data suggest that low levels of physical activity may be considered a risk factor for the development of depression and anxiety and can play an important role in the quality of life of individuals with epilepsy.


Assuntos
Epilepsia/complicações , Atividades de Lazer/psicologia , Transtornos do Humor/etiologia , Transtornos do Humor/psicologia , Atividade Motora/fisiologia , Adolescente , Adulto , Feminino , Humanos , Modelos Lineares , Masculino , Pessoa de Meia-Idade , Escalas de Graduação Psiquiátrica , Inquéritos e Questionários , Adulto Jovem
6.
Rev Paul Pediatr ; 42: e2023077, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-38126440

RESUMO

OBJECTIVE: To describe the first known case of human Bertiellosis in Paraná (Brazil). CASE DESCRIPTION: A 6-year-old male residing in the Brazilian state of Paraná was suffering from intermittent nonspecific abdominal pain and abdominal distension, associated with expulsion of live tapeworms in his feces for 7 months. He had a history of interaction with monkeys on an island. His first feces analysis was inconclusive, with an initial hypothesis of an atypical Taenia. However, after additional research, the parasitologist identified pregnant proglottids of Bertiella sp. The patient was initially treated with an unknown dosage of albendazole and nitazoxanide, as it was believed he had been infected with Taenia sp. Since the symptoms persisted, praziquantel 10 mg/kg was prescribed without further proglottids elimination. COMMENTS: Human Bertiellosis is a rare zoonosis, with less than one hundred cases reported. However, it is a cause of chronic abdominal pain and should be kept as a differential diagnosis, especially in cases reporting recurrent tapeworm expulsion in feces and refractory treatment with albendazole.


Assuntos
Cestoides , Infecções por Cestoides , Masculino , Criança , Animais , Humanos , Brasil , Albendazol/uso terapêutico , Infecções por Cestoides/diagnóstico , Dor Abdominal/etiologia
7.
Nat Commun ; 14(1): 5016, 2023 08 18.
Artigo em Inglês | MEDLINE | ID: mdl-37596248

RESUMO

TIGIT is an inhibitory receptor expressed on lymphocytes and can inhibit T cells by preventing CD226 co-stimulation through interactions in cis or through competition of shared ligands. Whether TIGIT directly delivers cell-intrinsic inhibitory signals in T cells remains unclear. Here we show, by analysing lymphocytes from matched human tumour and peripheral blood samples, that TIGIT and CD226 co-expression is rare on tumour-infiltrating lymphocytes. Using super-resolution microscopy and other techniques, we demonstrate that ligation with CD155 causes TIGIT to reorganise into dense nanoclusters, which coalesce with T cell receptor (TCR)-rich clusters at immune synapses. Functionally, this reduces cytokine secretion in a manner dependent on TIGIT's intracellular ITT-like signalling motif. Thus, we provide evidence that TIGIT directly inhibits lymphocyte activation, acting independently of CD226, requiring intracellular signalling that is proximal to the TCR. Within the subset of tumours where TIGIT-expressing cells do not commonly co-express CD226, this will likely be the dominant mechanism of action.


Assuntos
Ativação Linfocitária , Linfócitos do Interstício Tumoral , Humanos , Microscopia , Receptores Imunológicos/genética , Transdução de Sinais
8.
J Sex Med ; 9(8): 2111-21, 2012 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-22613050

RESUMO

INTRODUCTION: There is a high prevalence of erectile dysfunction (ED) in men with epilepsy; however, few studies have been conducted concerning the treatment of ED in this neurological group. AIM: The main purpose of this review is to highlight the influence of phosphodiesterase type 5 inhibitor (PDEI-5) for ED on seizure susceptibility. METHODS: All available online articles with information pertaining to PDEI-5 and seizure susceptibility were included in this review. MAIN OUTCOME MEASURES: The main outcome assessed demonstrated the intriguing role of PDEI-5 and its metabolites on seizure susceptibility. RESULTS: Case reports in men without epilepsy described seizure occurrence and electrophysiological changes following sildenafil, tadalafil, or vardenafil treatment. Consistent with these findings, preclinical studies suggested a proconvulsant effect of PDEI-5 on models of seizure induction. CONCLUSIONS: Evidence suggests an influence of PDEI-5 on seizure susceptibility in humans. In addition, preclinical studies have demonstrated the role of nitric oxide metabolites in the facilitation of paroxysmal phenomenon. Although there are many causes of seizures, medical professionals should be aware of the possible influence of PDEI-5 on seizure susceptibility. Further investigation by physicians and scientists is required to improve our understanding of this important topic.


Assuntos
Disfunção Erétil/tratamento farmacológico , Inibidores da Fosfodiesterase 5/efeitos adversos , Inibidores da Fosfodiesterase 5/uso terapêutico , Convulsões/induzido quimicamente , Idoso , Animais , Carbolinas/uso terapêutico , Suscetibilidade a Doenças , Disfunção Erétil/fisiopatologia , Humanos , Imidazóis/uso terapêutico , Masculino , Pessoa de Meia-Idade , Piperazinas/uso terapêutico , Prevalência , Purinas/uso terapêutico , Ratos , Citrato de Sildenafila , Sulfonas/uso terapêutico , Tadalafila , Triazinas/uso terapêutico , Dicloridrato de Vardenafila
9.
J Sex Med ; 9(9): 2266-72, 2012 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-22621812

RESUMO

INTRODUCTION: Epilepsy is a chronic disease that affects men and women of all ages, with different levels of severity. Many individuals with epilepsy also suffer from impairments in sexual function. However, it is difficult to differentiate between the impact of the disease and the impact of antiepileptic drugs on sexual function in human subjects. AIMS: To evaluate sexual behavior in adult male rats submitted to chronic pilocarpine-induced epilepsy. METHODS: First, non-epileptic rats were exposed to nine training sessions to acquire sexual experience, and their baseline sexual performance was evaluated. Then, the same rats were given pilocarpine to induce status epilepticus followed by chronic epilepsy. Once the animals had developed spontaneous recurrent seizures, their sexual behavior was evaluated during three sessions. MAIN OUTCOME MEASURES: Examine changes in latencies to first mount, intromission, and ejaculation, and the total number of mounts, intromissions, and ejaculations. RESULTS: All outcome measures related to sexual motivation and sexual performance were markedly impaired during chronic epilepsy compared with the baseline and the control group. CONCLUSION: These findings will aid in understanding the interaction between sexual behavior and epilepsy, as well as encouraging further experimental studies in human patients with epilepsy suffering from sexual dysfunction.


Assuntos
Epilepsia do Lobo Temporal/fisiopatologia , Comportamento Sexual Animal/fisiologia , Animais , Modelos Animais de Doenças , Epilepsia do Lobo Temporal/induzido quimicamente , Masculino , Agonistas Muscarínicos/farmacologia , Pilocarpina/farmacologia , Ratos , Ratos Wistar
10.
Front Immunol ; 12: 641521, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33796107

RESUMO

One mechanism by which monoclonal antibodies (mAb) help treat cancer or autoimmune disease is through triggering antibody-dependent cellular cytotoxicity (ADCC) via CD16 on Natural Killer (NK) cells. Afucosylation is known to increase the affinity of mAbs for CD16 on NK cells and here, we set out to assess how mAb afucosylation affects the dynamics of NK cell interactions, receptor expression and effector functions. An IgG1 version of a clinically important anti-CD20 mAb was compared to its afucosylated counterpart (anti-CD20-AF). Opsonization of CD20-expressing target cells, 721.221 or Daudi, with anti-CD20-AF increased NK cell cytotoxicity and IFNγ secretion, compared to anti-CD20. The afucosylated mAb also caused a more rapid and greater loss of CD16 from NK cell surfaces. Loss of CD16 has recently been shown to be important for NK cell detachment and sequential engagement of multiple target cells. Here, live-cell time-lapse microscopy of individual cell-cell interactions in an aqueous environment and a three-dimensional matrix, revealed that anti-CD20-AF induced more rapid killing of opsonized target cells. In addition, NK cells detached more quickly from target cells opsonized with anti-CD20-AF compared to anti-CD20, which increased engagement of multiple targets and enabled a greater proportion of NK cells to perform serial killing. Inhibition of CD16 shedding with TAPI-0 led to reduced detachment and serial killing. Thus, disassembly of the immune synapse caused by loss of cell surface CD16 is a factor determining the efficiency of ADCC and antibody afucosylation alters the dynamics of intercellular interactions to boost serial killing.


Assuntos
Anticorpos Monoclonais/química , Anticorpos Monoclonais/imunologia , Citotoxicidade Celular Dependente de Anticorpos/imunologia , Células Matadoras Naturais/imunologia , Receptores de IgG/imunologia , Antígenos CD20/imunologia , Fucose , Proteínas Ligadas por GPI/imunologia , Humanos , Imunoglobulina G , Sinapses Imunológicas/imunologia
11.
Foods ; 10(3)2021 Mar 02.
Artigo em Inglês | MEDLINE | ID: mdl-33801287

RESUMO

Seaweeds are a renewable natural source of valuable macro and micronutrients that have attracted the attention of the scientists in the last years. Their medicinal properties were already recognized in the ancient traditional Chinese medicine, but only recently there has been a considerable increase in the study of these organisms in attempts to demonstrate their health benefits. The extraction process and conditions to be used for the obtention of value-added compounds from seaweeds depends mainly on the desired final product. Thermochemical conversion of seaweeds, using high temperatures and solvents (including water), to obtain high-value products with more potential applications continues to be an industrial practice, frequently with adverse impact on the environment and products' functionality. However more recently, alternative methods and approaches have been suggested, searching not only to improve the process performance, but also to be less harmful for the environment. A biorefinery approach display a valuable idea of solving economic and environmental drawbacks, enabling less residues production close to the much recommended zero waste system. The aim of this work is to report about the new developed methods of seaweeds extractions and the potential application of the components extracted.

12.
Epilepsy Behav ; 17(3): 324-31, 2010 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-20133208

RESUMO

The relationship between sleep and epilepsy is both complex and clinically significant. Temporal lobe epilepsy (TLE) influences sleep architecture, while sleep plays an important role in facilitating and/or inhibiting possible epileptic seizures. The pilocarpine experimental model reproduces several features of human temporal lobe epilepsy and is one of the most widely used models in basic research. The aim of the present study was to characterize, behaviorally and electrophysiologically, the phases of sleep-wake cycles (SWC) in male rats with pilocarpine-induced epilepsy. Epileptic rats presented spikes in all phases of the SWC as well as atypical cortical synchronization during attentive wakefulness and paradoxical sleep. The architecture of the sleep-wake phases was altered in epileptic rats, as was the integrity of the SWC. Because our findings reproduce many relevant features observed in patients with epilepsy, this model is suitable to study sleep dysfunction in epilepsy.


Assuntos
Epilepsia do Lobo Temporal/fisiopatologia , Sono/fisiologia , Vigília/fisiologia , Análise de Variância , Animais , Encéfalo/fisiopatologia , Modelos Animais de Doenças , Eletroencefalografia/métodos , Epilepsia do Lobo Temporal/induzido quimicamente , Epilepsia do Lobo Temporal/patologia , Masculino , Pilocarpina , Ratos , Ratos Sprague-Dawley , Sono/efeitos dos fármacos , Vigília/efeitos dos fármacos
13.
Artigo em Inglês | LILACS-Express | LILACS | ID: biblio-1529492

RESUMO

ABSTRACT Objective: To describe the first known case of human Bertiellosis in Paraná (Brazil). Case description: A 6-year-old male residing in the Brazilian state of Paraná was suffering from intermittent nonspecific abdominal pain and abdominal distension, associated with expulsion of live tapeworms in his feces for 7 months. He had a history of interaction with monkeys on an island. His first feces analysis was inconclusive, with an initial hypothesis of an atypical Taenia. However, after additional research, the parasitologist identified pregnant proglottids of Bertiella sp. The patient was initially treated with an unknown dosage of albendazole and nitazoxanide, as it was believed he had been infected with Taenia sp. Since the symptoms persisted, praziquantel 10 mg/kg was prescribed without further proglottids elimination. Comments: Human Bertiellosis is a rare zoonosis, with less than one hundred cases reported. However, it is a cause of chronic abdominal pain and should be kept as a differential diagnosis, especially in cases reporting recurrent tapeworm expulsion in feces and refractory treatment with albendazole.


RESUMO Objetivo: Descrever o primeiro caso conhecido de bertielose humana no Paraná, Brasil. Descrição do caso: Criança de seis anos do sexo masculino, residente no Paraná, Brasil, apresentava dor abdominal inespecífica intermitente e distensão abdominal, associadas à expulsão de helmintos vivos em suas fezes havia sete meses. Tinha um histórico de interação com macacos em uma ilha. Sua primeira análise de fezes foi inconclusiva, com hipótese inicial de uma Taenia atípica. No entanto, após pesquisas adicionais, o parasitologista identificou proglótides gravídicas de Bertiella sp. O paciente foi inicialmente tratado com uma dosagem desconhecida de albendazol e nitazoxanida, pois se acreditava que havia sido infectado por Taenia sp. Diante da persistência dos sintomas, foi prescrito praziquantel 10 mg/kg, sem mais eliminação de proglótides. Comentários: A bertielose humana é uma zoonose rara, com menos de cem casos relatados. No entanto, é uma causa de dor abdominal crônica e deve ser mantida como diagnóstico diferencial, principalmente nos casos que relatam expulsão recorrente de helmintos nas fezes e que são refratários ao tratamento com albendazol.

16.
J Cell Biol ; 217(9): 3267-3283, 2018 09 03.
Artigo em Inglês | MEDLINE | ID: mdl-29967280

RESUMO

Natural Killer (NK) cells can engage multiple virally infected or tumor cells sequentially and deliver perforin for cytolytic killing of these targets. Using microscopy to visualize degranulation from individual NK cells, we found that repeated activation via the Fc receptor CD16 decreased the amount of perforin secreted. However, perforin secretion was restored upon subsequent activation via a different activating receptor, NKG2D. Repeated stimulation via NKG2D also decreased perforin secretion, but this was not rescued by stimulation via CD16. These different outcomes of sequential stimulation could be accounted for by shedding of CD16 being triggered by cellular activation. The use of pharmacological inhibitors and NK cells transfected to express a noncleavable form of CD16 revealed that CD16 shedding also increased NK cell motility and facilitated detachment of NK cells from target cells. Disassembly of the immune synapse caused by CD16 shedding aided NK cell survival and boosted serial engagement of target cells. Thus, counterintuitively, shedding of CD16 may positively impact immune responses.


Assuntos
Citotoxicidade Imunológica/imunologia , Células Matadoras Naturais/imunologia , Neoplasias/imunologia , Receptores de IgG/metabolismo , Antineoplásicos Imunológicos/farmacologia , Degranulação Celular/imunologia , Linhagem Celular Tumoral , Movimento Celular/imunologia , Proteínas Ligadas por GPI/genética , Proteínas Ligadas por GPI/metabolismo , Humanos , Células Matadoras Naturais/citologia , Ativação Linfocitária/imunologia , Subfamília K de Receptores Semelhantes a Lectina de Células NK/metabolismo , Perforina/metabolismo , Receptores de IgG/genética , Rituximab/farmacologia
20.
Epilepsy Res ; 136: 54-61, 2017 10.
Artigo em Inglês | MEDLINE | ID: mdl-28772197

RESUMO

OBJECTIVE: Our aim was to investigate the influence of an acute exercise session on sleep pattern in rats with temporal lobe epilepsy (TLE). METHODS: Twenty male Wistar rats were randomly assigned to 4 groups: control (C); acute exercise (EX); epilepsy (E) and epilepsy acute exercise (EEX). Two sleep electrocorticography recordings were performed during the light phase [baseline and day 2 (after the acute physical exercise session)]. After baseline recording, the exercise groups (EX and EEX) were submitted to an exercise session on a motor-driven treadmill at 12m/min for 30min. Twelve hours later, the rats were submitted to the second sleep recording. RESULTS: At baseline, the E group showed a higher wakefulness and a lower Total sleep time, Slow Wave Sleep and REM sleep compared with the C group. After acute exercise, there was an increase in Total sleep time and Slow Wave Sleep and a decrease of wakefulness in EEX (+11.10%, +20.29% and -11.25%, respectively) and EX (+5.20%, +11.60% and -8.12%, respectively) groups. CONCLUSION: These findings suggest that acute physical exercise positively impacts the sleep pattern of rats with TLE, inducing a more consolidated sleep.


Assuntos
Epilepsia do Lobo Temporal/fisiopatologia , Atividade Motora/fisiologia , Sono/fisiologia , Animais , Encéfalo/fisiopatologia , Modelos Animais de Doenças , Eletrocorticografia , Eletrodos Implantados , Epilepsia do Lobo Temporal/terapia , Terapia por Exercício , Masculino , Pilocarpina , Distribuição Aleatória , Ratos Wistar
SELEÇÃO DE REFERÊNCIAS
Detalhe da pesquisa