Detalhe da pesquisa
1.
Toll-Like Receptor 8 Agonist GS-9688 Induces Sustained Efficacy in the Woodchuck Model of Chronic Hepatitis B.
Hepatology
; 73(1): 53-67, 2021 01.
Artigo
Inglês
| MEDLINE | ID: mdl-32246499
2.
Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor.
Bioorg Med Chem
; 27(3): 457-469, 2019 02 01.
Artigo
Inglês
| MEDLINE | ID: mdl-30606676
3.
Discovery of a 2'-fluoro-2'-C-methyl C-nucleotide HCV polymerase inhibitor and a phosphoramidate prodrug with favorable properties.
Bioorg Med Chem Lett
; 27(8): 1840-1847, 2017 04 15.
Artigo
Inglês
| MEDLINE | ID: mdl-28274633
4.
Synthesis and characterization of 1'-C-cyano-2'-fluoro-2'-C-methyl pyrimidine nucleosides as HCV polymerase inhibitors.
Bioorg Med Chem Lett
; 25(5): 1040-3, 2015 Mar 01.
Artigo
Inglês
| MEDLINE | ID: mdl-25650256
5.
Preparation and biological evaluation of 1'-cyano-2'-C-methyl pyrimidine nucleosides as HCV NS5B polymerase inhibitors.
Bioorg Med Chem Lett
; 24(14): 3092-5, 2014 Jul 15.
Artigo
Inglês
| MEDLINE | ID: mdl-24907145
6.
Origin of rebound virus in chronically SIV-infected Rhesus monkeys following treatment discontinuation.
Nat Commun
; 11(1): 5412, 2020 10 27.
Artigo
Inglês
| MEDLINE | ID: mdl-33110078
7.
Discovery of GS-9688 (Selgantolimod) as a Potent and Selective Oral Toll-Like Receptor 8 Agonist for the Treatment of Chronic Hepatitis B.
J Med Chem
; 63(18): 10188-10203, 2020 09 24.
Artigo
Inglês
| MEDLINE | ID: mdl-32407112
8.
Tricyclic HIV integrase inhibitors: VI. SAR studies of 'benzyl flipped' C3-substituted pyrroloquinolines.
Bioorg Med Chem Lett
; 19(4): 1187-90, 2009 Feb 15.
Artigo
Inglês
| MEDLINE | ID: mdl-19167883
9.
Tricyclic HIV integrase inhibitors V. SAR studies on the benzyl moiety.
Bioorg Med Chem Lett
; 19(8): 2263-5, 2009 Apr 15.
Artigo
Inglês
| MEDLINE | ID: mdl-19285389
10.
Tricyclic HIV integrase inhibitors: potent and orally bioavailable C5-aza analogs.
Bioorg Med Chem Lett
; 18(4): 1388-91, 2008 Feb 15.
Artigo
Inglês
| MEDLINE | ID: mdl-18207398
11.
Discovery of a Potent and Orally Bioavailable Cyclophilin Inhibitor Derived from the Sanglifehrin Macrocycle.
J Med Chem
; 61(21): 9473-9499, 2018 11 08.
Artigo
Inglês
| MEDLINE | ID: mdl-30074795
12.
Synthesis of 1'-C-cyano pyrimidine nucleosides and characterization as HCV polymerase inhibitors.
Nucleosides Nucleotides Nucleic Acids
; 34(11): 763-85, 2015.
Artigo
Inglês
| MEDLINE | ID: mdl-26398773
13.
Highly potent HCV NS4B inhibitors with activity against multiple genotypes.
J Med Chem
; 57(5): 2161-6, 2014 Mar 13.
Artigo
Inglês
| MEDLINE | ID: mdl-24512292
14.
Effect of substitution on novel tricyclic HIV-1 integrase inhibitors.
Bioorg Med Chem Lett
; 16(15): 4031-5, 2006 Aug 01.
Artigo
Inglês
| MEDLINE | ID: mdl-16716589