Detalhe da pesquisa
1.
Employing Photocatalysis for the Design and Preparation of DNA-Encoded Libraries: A Case Study.
Chem Rec
; 21(4): 616-630, 2021 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-33570227
2.
Discovery of soluble epoxide hydrolase inhibitors through DNA-encoded library technology (ELT).
Bioorg Med Chem
; 41: 116216, 2021 07 01.
Artigo
Inglês
| MEDLINE | ID: mdl-34023664
3.
Application of encoded library technology (ELT) to a protein-protein interaction target: discovery of a potent class of integrin lymphocyte function-associated antigen 1 (LFA-1) antagonists.
Bioorg Med Chem
; 22(7): 2353-65, 2014 Apr 01.
Artigo
Inglês
| MEDLINE | ID: mdl-24593905
4.
Metabolites of PPI-2458, a selective, irreversible inhibitor of methionine aminopeptidase-2: structure determination and in vivo activity.
Drug Metab Dispos
; 41(4): 814-26, 2013 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-23355637
5.
In vitro and in vivo characterization of a novel soluble epoxide hydrolase inhibitor.
Prostaglandins Other Lipid Mediat
; 104-105: 25-31, 2013.
Artigo
Inglês
| MEDLINE | ID: mdl-23434473
6.
Exploring amino acids derivatives as potent, selective, and direct agonists of sphingosine-1-phosphate receptor subtype-1.
Bioorg Med Chem Lett
; 23(2): 472-5, 2013 Jan 15.
Artigo
Inglês
| MEDLINE | ID: mdl-23245510
7.
PAC-FragmentDEL - photoactivated covalent capture of DNA-encoded fragments for hit discovery.
RSC Med Chem
; 13(11): 1341-1349, 2022 Nov 16.
Artigo
Inglês
| MEDLINE | ID: mdl-36426238
8.
Design, synthesis and selection of DNA-encoded small-molecule libraries.
Nat Chem Biol
; 5(9): 647-54, 2009 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-19648931
9.
Exploration of amino alcohol derivatives as novel, potent, and highly selective sphingosine-1-phosphate receptor subtype-1 agonists.
Bioorg Med Chem Lett
; 20(8): 2520-4, 2010 Apr 15.
Artigo
Inglês
| MEDLINE | ID: mdl-20304639
10.
Characterization of Specific N-α-Acetyltransferase 50 (Naa50) Inhibitors Identified Using a DNA Encoded Library.
ACS Med Chem Lett
; 11(6): 1175-1184, 2020 Jun 11.
Artigo
Inglês
| MEDLINE | ID: mdl-32550998
11.
Synthesis and evaluation of alkoxy-phenylamides and alkoxy-phenylimidazoles as potent sphingosine-1-phosphate receptor subtype-1 agonists.
Bioorg Med Chem Lett
; 19(2): 369-72, 2009 Jan 15.
Artigo
Inglês
| MEDLINE | ID: mdl-19081720
12.
Synthesis and evaluation of arylalkoxy- and biarylalkoxy-phenylamide and phenylimidazoles as potent and selective sphingosine-1-phosphate receptor subtype-1 agonists.
Bioorg Med Chem Lett
; 19(8): 2315-9, 2009 Apr 15.
Artigo
Inglês
| MEDLINE | ID: mdl-19282175
13.
Antiparasitic activities of novel, orally available fumagillin analogs.
Bioorg Med Chem Lett
; 19(17): 5128-31, 2009 Sep 01.
Artigo
Inglês
| MEDLINE | ID: mdl-19648008
14.
Discovery of Potent and Selective Inhibitors for ADAMTS-4 through DNA-Encoded Library Technology (ELT).
ACS Med Chem Lett
; 6(8): 888-93, 2015 Aug 13.
Artigo
Inglês
| MEDLINE | ID: mdl-26288689
15.
Discovery, SAR, and X-ray Binding Mode Study of BCATm Inhibitors from a Novel DNA-Encoded Library.
ACS Med Chem Lett
; 6(8): 919-24, 2015 Aug 13.
Artigo
Inglês
| MEDLINE | ID: mdl-26288694
16.
Discovery of Clinical Candidate GSK1842799 As a Selective S1P1 Receptor Agonist (Prodrug) for Multiple Sclerosis.
ACS Med Chem Lett
; 4(10): 942-7, 2013 Oct 10.
Artigo
Inglês
| MEDLINE | ID: mdl-24900589
17.
Orally active fumagillin analogues: transformations of a reactive warhead in the gastric environment.
ACS Med Chem Lett
; 4(4): 381-6, 2013 Apr 11.
Artigo
Inglês
| MEDLINE | ID: mdl-24900682
18.
Discovery of highly potent and selective small molecule ADAMTS-5 inhibitors that inhibit human cartilage degradation via encoded library technology (ELT).
J Med Chem
; 55(16): 7061-79, 2012 Aug 23.
Artigo
Inglês
| MEDLINE | ID: mdl-22891645
19.
Carbamate analogues of fumagillin as potent, targeted inhibitors of methionine aminopeptidase-2.
J Med Chem
; 52(24): 8047-56, 2009 Dec 24.
Artigo
Inglês
| MEDLINE | ID: mdl-19929003
20.
Rapid determination of substrate specificity of Clostridium histolyticum beta-collagenase using an immobilized peptide library.
J Biol Chem
; 277(10): 8366-71, 2002 Mar 08.
Artigo
Inglês
| MEDLINE | ID: mdl-11724807